Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia

Gielen, 2009, Risk factor management: antiatherogenic therapies, Eur J Cardiovasc Prev Rehabil, 16, S29, 10.1097/01.hjr.0000359233.58023.64

Lorenzo, 2010, Insulin resistance, beta-cell dysfunction, and conversion to type 2 diabetes in a multiethnic population: the Insulin Resistance Atherosclerosis Study, Diabetes Care, 33, 67, 10.2337/dc09-1115

Baigent, 2005, Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins, Lancet, 366, 1267, 10.1016/S0140-6736(05)67394-1

Cannon, 2006, Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy, J Am Coll Cardiol, 48, 438, 10.1016/j.jacc.2006.04.070

Jones, 2008, Expert perspective: reducing cardiovascular risk in metabolic syndrome and type 2 diabetes mellitus beyond low-density lipoprotein cholesterol lowering, Am J Cardiol, 102, 41L, 10.1016/j.amjcard.2008.09.074

Alsheikh-Ali, 2009, The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials, Curr Atheroscler Rep, 11, 100, 10.1007/s11883-009-0016-8

Joy, 2009, Narrative review: statin-related myopathy, Ann Intern Med, 150, 858, 10.7326/0003-4819-150-12-200906160-00009

Dohadwala, 2009, Grapes and cardiovascular disease, J Nutr, 139, 1788S, 10.3945/jn.109.107474

Gorinstein, 2006, Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans, J Agric Food Chem, 54, 1887, 10.1021/jf058171g

Jeon, 2001, Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits, Life Sci, 69, 2855, 10.1016/S0024-3205(01)01363-7

Whitman, 2005, Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages, Atherosclerosis, 178, 25, 10.1016/j.atherosclerosis.2004.07.034

Eguchi, 2006, Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells, FEBS Lett, 580, 3321, 10.1016/j.febslet.2006.04.077

Kim, 2007, Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells, Biol Pharm Bull, 30, 2345, 10.1248/bpb.30.2345

Gouedard, 2004, Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism, Mol Cell Biol, 24, 5209, 10.1128/MCB.24.12.5209-5222.2004

Vinson, 2002, Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease, Adv Exp Med Biol, 505, 113, 10.1007/978-1-4757-5235-9_10

Devaraj, 2004, Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals, Arterioscler Thromb Vasc Biol, 24, e25, 10.1161/01.ATV.0000120784.08823.99

Kaplan, 2001, Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis, J Nutr, 131, 2082, 10.1093/jn/131.8.2082

Dugo, 2005, Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS, J Sep Sci, 28, 1149, 10.1002/jssc.200500053

Nogata, 2006, Flavonoid composition of fruit tissues of citrus species, Biosci Biotechnol Biochem, 70, 178, 10.1271/bbb.70.178

Choe, 2001, Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits, J Cardiovasc Pharmacol, 38, 947, 10.1097/00005344-200112000-00017

Jeong, 2007, Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL, Br J Nutr, 97, 447, 10.1017/S0007114507657894

Yu, 2005, Antioxidant activity of citrus limonoids, flavonoids, and coumarins, J Agric Food Chem, 53, 2009, 10.1021/jf0484632

Di Donna, 2009, Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides, J Nat Prod, 72, 1352, 10.1021/np900096w

Miceli, 2007, Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet, J Agric Food Chem, 55, 10671, 10.1021/jf071772i

Mollace, 2008, The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation, J Cardiovasc Pharmacol Ther, 13, 120, 10.1177/1074248407313821

Mollace, 2011, Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies, Fitoterapia, 82, 309, 10.1016/j.fitote.2010.10.014

Bok, 1999, Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids, J Nutr, 129, 1182, 10.1093/jn/129.6.1182

Marounek, 2007, Effect of pectin and amidated pectin on cholesterol homeostasis and cecal metabolism in rats fed a high-cholesterol diet, Physiol Res, 56, 433, 10.33549/physiolres.930967

Terpstra, 1998, Dietary pectin with high viscosity lowers plasma and liver cholesterol concentration and plasma cholesteryl ester transfer protein activity in hamsters, J Nutr, 128, 1944, 10.1093/jn/128.11.1944

Anonymous, 2002, The hypocholesterolemic effect of lemon peels, lemon pectin, and the waste stream material of lemon peels in hybrid F1B hamsters, Eur J Nutr, 41, 19, 10.1007/s003940200002

Garcia-Diez, 1996, Pectin feeding influences fecal bile acid excretion, hepatic bile acid and cholesterol synthesis and serum cholesterol in rats, J Nutr, 126, 1766

Cha, 2001, Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats, Plant Foods Hum Nutr, 56, 349, 10.1023/A:1011884200848

Borradaile, 1999, Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin, Lipids, 34, 591, 10.1007/s11745-999-0403-7

Wilcox, 2001, Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP, J Lipid Res, 42, 725, 10.1016/S0022-2275(20)31634-5

Huong, 2006, Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids, Nutrition, 22, 546, 10.1016/j.nut.2005.11.006

Li, 2006, Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin, Int J Biochem Cell Biol, 38, 985, 10.1016/j.biocel.2005.10.002

Shin, 1999, Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats, Int J Vitam Nutr Res, 69, 341, 10.1024/0300-9831.69.5.341

Leopoldini, 2010, On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme, J Agric Food Chem, 58, 10768, 10.1021/jf102576j

Muscoli, 2004, The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1, J Pharmacol Exp Ther, 311, 44, 10.1124/jpet.104.068205

Li, 2001, Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation, Cardiovasc Res, 52, 130, 10.1016/S0008-6363(01)00371-6