Benzodiazepine receptor ligands

Il Farmaco - Tập 54 - Trang 375-389 - 1999
G. Guerrini1, A. Costanzo1, F. Bruni1, G. Ciciani1, S. Selleri1, P. Gratteri1, B. Costa2, C. Martini2, A. Lucacchini2
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze, Via Gino Capponi 9, 50121 Florence, Italy
2Istituto Policattedra Discipline Biologiche, Università degli Studi di Pisa, Via Bonanno 6, 56100 Pisa, Italy

Tài liệu tham khảo

Costanzo, 1994, Reactivity of 1-(2-nitrophenyl)-5-aminopyrazoles under basic conditions and synthesis of new 3-, 7-, and 8-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides, as benzodiazepine receptor ligands, J. Heterocycl. Chem., 31, 1369, 10.1002/jhet.5570310612 Guerrini, 1996, Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 3-, 7- and 8-substituted [5,1-c][1,2,4]benzotriazines and 5-oxide derivatives. Part I, Eur. J. Med. Chem., 31, 259, 10.1016/0223-5234(96)80363-1 Zhang, 1995, Development of a comprehensive pharmacophore model for the benzodiazepine receptor, Drug Des. Discov., 12, 193 Schove, 1994, Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site, Bioorg. Med. Chem., 2, 1029, 10.1016/S0968-0896(00)82053-2 Schove, 1995, A behaviorally selective class of thiophene-containing benzodiazepine receptor ligands, Bioorg. Med. Chem., 3, 1547, 10.1016/0968-0896(95)00135-4 Marshall, 1979, The active analog approach, 87 Hollinshead, 1990, Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester, J. Med. Chem., 33, 1062, 10.1021/jm00165a028 Arauzo, 1991, The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic, J. Med. Chem., 34, 1754, 10.1021/jm00109a035 Zhang, 1994, Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors, J. Med. Chem., 37, 745, 10.1021/jm00032a007 Martin, 1992, Molecular yardsticks. Rigid probes to define the spatial dimension of the benzodiazepine receptor binding site, J. Med. Chem., 35, 4105, 10.1021/jm00100a017 Allen, 1990, Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site, J. Med. Chem., 33, 2343, 10.1021/jm00171a007 Trudell, 1990, Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b′]diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties, J. Med. Chem., 33, 2412, 10.1021/jm00171a015 Southwick, 1975, Preparation of 4,6-diamminopyrazolo[3,4-d]pyrimidines with variations in substitution at the 1- and 3-positions (1), J. Heterocycl. Chem., 12, 1199, 10.1002/jhet.5570120621 Cheng, 1956, Potential purine antagonists. VI. Synthesis of 1-alkyl- and 1-aryl-4-substituted pyrazolo[3,4-d]pyrimidines, J. Org. Chem., 21, 1240, 10.1021/jo01117a010 Bruni, 1993, Synthesis and study of the anti-inflammatory properties of some pyrazolo[1,5-a]pyrimidine derivatives, J. Pharm. Sci., 82, 480, 10.1002/jps.2600820510 Musante, 1958, Sul furoil-piruvato di etile: composti eterociclici contenenti il nucleo del furano, Gazz. Chim. Ital., 88, 879 Roger, H.O. Calvery, Ethyl Phenylcyanopyruvate in Organic Syntheses, Collective II, Wiley, 1943, p. 287–288. Selleri, 1995, New 2,3-substituted 4,7-dihydro-6-(1′H-pyrazol-3′-yl)pyrazolo[1,5-a]pyrimidin-7-ones and related compounds: synthesis and benzodiazepine receptor binding study, Farmaco, 50, 679 Ahmad, 1971, Pyrazolotriazines from condensation of nitro with amino groups, J. Org. Chem., 36, 2972, 10.1021/jo00819a014 Da Settimo, 1997, Isosteric replacement of amide by ester function. Synthesis and benzodiazepine receptor affinity of indol-3-ylglyoxylyl ester derivatives, Farmaco, 52, 421