Lợi ích của việc Tăng cường Biểu hiện Yếu tố Tăng trưởng Giống Insulin I (IGF-I) Qua Virus Virus Liên kết Adeno-Recombinant (rAAV) Đối với Sự Tái tạo Lâu Dài Sụn Khớp Người Bị Viêm Khớp

Poole AR. (1999) An introduction to the pathophysiology of osteoarthritis. Front. Biosci. 4:D662–70. Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel-Pelletier J. (1993) Cytokines and inflammation in cartilage degradation. Rheum. Dis. Clin. North Am. 19:545–68. Conde J, et al. (2011) Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis. 2011:203901. Goldring MB, Otero M. (2011) Inflammation in osteoarthritis. Curr. Opin. Rheumatol. 23:471–8. Dumond H, et al. (2003) Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 48:3118–29. Baragi VM, et al. (1995) Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J. Clin. Invest. 96:2454–60. Pelletier JP, et al. (1997) In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum. 40:1012–9. Fernandes J, et al. (1999) In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am. J. Pathol. 154:1159–69. Frisbie DD, McIlwraith CW. (2000) Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis. Clin. Orthop. Relat. Res. 379 (Suppl.):S273–87. Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW. (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther. 9:12–20. Kafienah W, Al-Fayez F, Hollander AP, Barker MD. (2003) Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach. Arthritis Rheum. 48:709–18. Zhang X, Mao Z, Yu C. (2004) Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J. Orthop. Res. 22:742–50. Haupt JL, et al. (2005) Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J. Orthop. Res. 23:118–26. Nixon AJ, et al. (2005) Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther. 12:177–86. Grossin L, et al. (2006) Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. FASEB J. 20:65–75. Gouze JN, et al. (2004) Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes. Osteoarthritis Cartilage. 12:217–24. Hsieh JL, et al. (2010) Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J. Orthop. Res. 28:1300–6. Hsieh JL, et al. (2009) Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection. Hum. Gene Ther. 20:147–58. Chen LX, et al. (2008) Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA. Osteoarthritis Cartilage. 16 174–84. Cucchiarini M, Terwilliger EF, Kohn D, Madry H. (2009) Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer. J. Cell. Mol. Med. 13:2476–88. Chen B, Qin J, Wang H, Magdalou J, Chen L. (2010) Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits. Exp. Mol. Med. 42:684–95. Smith P, et al. (2000) Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum. 43:1156–64. Matsumoto T, et al. (2009) Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Arthritis Rheum. 60:1390–405. Ulrich-Vinther M, Stengaard C, Schwarz EM, Goldring MB, Soballe K. (2005) Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism. Eur. Cell. Mater. 10:40–50. Blaney Davidson EN, Vitters EL, van den Berg WB, van der Kraan PM. (2006) TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7. Arthritis Res. Ther. 8:R65–72. Tew SR, et al. (2005) Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage. 13:80–9. Cucchiarini M, et al. (2007) Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum. 56:158–67. Venkatesan N, et al. (2004) Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Proc. Natl. Acad. Sci. U. S. A. 101:18087–92. Surendran S, et al. (2006) Anti-apoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis. J. Bone Joint Surg. Br. 88:1660–5. Piera-Velazquez S, Jimenez SA, Stokes D. (2002) Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum. 46:683–93. Cucchiarini M, et al. (2005) Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol. Ther. 12:229–38. Evans CH, Gouze JN, Gouze E, Robbins PD, Ghivizzani SC. (2004) Osteoarthritis gene therapy. Gene Ther. 11 379–89. Boileau C, et al. (2006) PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect. Ann. Rheum. Dis. 65:573–80. Pelletier JP, et al. (2003) In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis Rheum. 48:1582–93. Starkman BG, Cravero JD, Delcarlo M, Loeser RF. (2005) IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem. J. 389:723–9. Yin W, Park JI, Loeser RF. (2009) Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-kinase-Akt and MEK-ERK MAPK signaling pathways. J. Biol. Chem. 284:31972–81. Shakibaei M, Seifarth C, John T, Rahmanzadeh M, Mobasheri A. (2006) Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem. Pharmacol. 72:1382–95. Loeser RF, Erickson EA, Long DL. (2008) Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr. Opin. Rheumatol. 20:581–6. Beier F, Loeser RF. (2010) Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J. Cell. Biochem. 110:573–80. Martin JA, Ellerbroek SM, Buckwalter JA. (1997) Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J. Orthop. Res. 15:491–8. Neidel J, et al. (1997) Elevated levels of insulinlike growth factor (IGF) binding protein-3 in rheumatoid arthritis synovial fluid inhibit stimulation by IGF-I of articular chondrocyte proteoglycan synthesis. Rheumatol. Int. 17:29–37. Kiepe D, et al. (2001) Intact IGF-binding protein-4 and -5 and their respective fragments isolated from chronic renal failure serum differentially modulate IGF-I actions in cultured growth plate chondrocytes. J. Am. Soc. Nephrol. 12:2400–10. Kiepe D, Ciarmatori S, Haarmann A, Tonshoff B. (2006) Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: the functional role of IGFBP-5. Am. J. Physiol. Endocrinol. Metab. 290:E363–71. Mankin HJ, Dorfman H, Lippiello L, Zarins A. (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J. Bone Joint Surg. Am. 53:523–37. Madry H, Cucchiarini M, Terwilliger EF, Trippel SB. (2003) Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum. Gene Ther. 14:393–402. Madry, et al. (2003) Recombinant adeno-associated virus vectors efficiently transduce ligaments and tendons in vivo. In: 49th Annual Meeting of the Orthopaedic Research Society; 2003 Feb 2–5; New Orleans, LA. Poster nr 0918. Available from: http://www.ors.org/abstracts/ Samulski RJ, Chang LS, Shenk T. (1987) A recombinant plasmid from which an infectious adenoassociated virus genome can be excised in vitro and its use to study viral replication. J. Virol. 61:3096–101. Samulski RJ, Chang LS, Shenk T. (1989) Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J. Virol. 63:3822–8. Cucchiarini M, Ren XL, Perides G, Terwilliger EF. (2003) Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors. Gene Ther. 10:657–67. Cucchiarini M, Ekici M, Schetting S, Kohn D, Madry H. (2011) Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following rAAV-mediated gene transfer and overexpression of fibroblast growth factor 2. Tissue Eng. Part A. 17:1921–33. Jansen M, et al. (1983) Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 306:609–11. Madry H, Zurakowski D, Trippel SB. (2001) Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther. 8:1443–9. Aigner T, Bertling W, Stoss H, Weseloh G, von der Mark K. (1993) Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage. J. Clin. Invest. 91:829–37. Olney RC, et al. (1996) Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. J. Clin. Endocrinol. Metab. 81:1096–103. Eviatar T, Kauffman H, Maroudas A. (2003) Synthesis of insulin-like growth factor binding protein 3 in vitro in human articular cartilage cultures. Arthritis Rheum. 48:410–7. Iwanaga H, et al. (2005) Enhanced expression of insulin-like growth factor-binding proteins in human osteoarthritic cartilage detected by immunohistochemistry and in situ hybridization. Osteoarthritis Cartilage. 13:439–48. Hunziker EB, Kapfinger E, Martin J, Buckwalter J, Morales TI. (2008) Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage. Osteoarthritis Cartilage. 16:185–94. Morales TI. (2008) The quantitative and functional relation between insulin-like growth factor-I (IGF) and IGF-binding proteins during human osteoarthritis. J. Orthop. Res. 26:465–74. Dore S, et al. (1994) Human osteoarthritic chondrocytes possess an increased number of insulinlike growth factor 1 binding sites but are unresponsive to its stimulation: possible role of IGF-1-binding proteins. Arthritis Rheum. 37:253–63. Hansen J, Qing K, Kwon HJ, Mah C, Srivastava A. (2000) Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts. J. Virol. 74:992–6. Adriaansen J, et al. (2005) Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy. Ann. Rheum. Dis. 64:1677–84. Boissier MC, et al. (2007) Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype. Hum. Gene Ther. 18:525–35. Madry H, et al. (2002) Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum. Gene Ther. 13:1621–30. Shi S, Mercer S, Trippel SB. (2010) Effect of transfection strategy on growth factor overexpression by articular chondrocytes. J.Orthop. Res. 28:103–9. Madry H, Trippel SB. (2000) Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther. 7:286–91. Mi Z, et al. (2000) Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum. 43:2563–70. Brower-Toland BD, et al. (2001) Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum. Gene Ther. 12:117–29. Madry H, et al. (2005) Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther. 12:1171–9. Osborn KD, Trippel SB, Mankin HJ. (1989) Growth factor stimulation of adult articular cartilage. J. Orthop. Res. 7:35–42. Goldring MB, Goldring SR. (1990) Skeletal tissue response to cytokines. Clin. Orthop. Relat. Res. 258:245–78. Trippel SB. (1995) Growth factor actions on articular cartilage. J. Rheumatol. Suppl. 43:129–32. Martel-Pelletier J, Di Battista JA, Lajeunesse D, Pelletier JP. (1998) IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis. Inflamm. Res. 47:90–100. Matsumoto T, Gargosky SE, Oh Y, Rosenfeld RG. (1996) Transcriptional and post-translational regulation of insulin-like growth factor-binding protein-5 in rat articular chondrocytes. J. Endocrinol. 148:355–69. Sunic D, McNeil JD, Rayner TE, Andress DL, Belford DA. (1998) Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes. Endocrinology. 139:2356–62. Porter RM, Akers RM, Howard RD, Forsten-Williams K. (2007) Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta. Tissue Eng. 13:1333–45. Yoon DM, Fisher JP. (2008) Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes. Tissue Eng. Part A. 14:1263–73. Bell DM, et al. (1997) SOX9 directly regulates the type-II collagen gene. Nat. Genet. 16:174–8. Lefebvre V, Huang W, Harley VR, Goodfellow PN, de Crombrugghe B. (1997) SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol. Cell. Biol. 17:2336–46. Vincent AM, Feldman EL. (2002) Control of cell survival by IGF signaling pathways. Growth Horm. IGF Res. 12:193–7. Canalis E. (1980) Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria. J. Clin. Invest. 66:709–19. Massicotte F, et al. (2006) Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts. Arthritis Res. Ther. 8:R177–88. Goldring MB, Fukuo K, Birkhead JR, Dudek E, Sandell LJ. (1994) Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes. J. Cell. Biochem. 54:85–99. Apparailly F, et al. (2002) Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum. Gene Ther. 13:1179–88. Aigner T, et al. (2010) Histopathology atlas of animal model systems: overview of guiding principles. Osteoarthritis Cartilage. 18 (Suppl. 3):S2–6.