Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes—OA management
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ahangar P, Mills SJ, Cowin AJ (2020) Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Int J Mol Sci. https://doi.org/10.3390/ijms21197038
Antwi AO, Obiri DD, Osafo N, Essel LB, Forkuo AD, Atobiga C (2018) Stigmasterol alleviates cutaneous allergic responses in rodents. Biomed Res Int. https://doi.org/10.1155/2018/3984068
Benavides-Castellanos MP, Garzón-Orjuela N, Linero I (2020) Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis. Cell Regener (london, England) 9:5. https://doi.org/10.1186/s13619-020-00047-3
Charlier E, Relic B, Deroyer C, Malaise O, Neuville S, Collée J, Malaise MG, De Seny D (2016) Insights on molecular mechanisms of chondrocytes death in osteoarthritis. Int J Mol Sci 17:2146. https://doi.org/10.3390/ijms17122146
Chen L, Tredget EE, Wu PY, Wu Y (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 3:e1886. https://doi.org/10.1371/journal.pone.0001886
Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, Im HJ (2017) Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res 5:16044. https://doi.org/10.1038/boneres.2016.44
Chen W, Sun Y, Gu X, Hao Y, Liu X, Lin J, Chen J, Chen S (2019) Conditioned medium of mesenchymal stem cells delays osteoarthritis progression in a rat model by protecting subchondral bone, maintaining matrix homeostasis, and enhancing autophagy. J Tissue Eng Regen Med 13:1618–1628. https://doi.org/10.1002/term.2916
Chen WP, Yu C, Hu PF, Bao JP, Tang JL, Wu JD (2012) Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochimica Polonica https://doi.org/10.18388/abp.2012_2088
Cho JW, Kang MC (2010) TGF-β1-treated ADSCs-CM promotes expression of type I collagen and MMP-1, migration of human skin fibroblasts, and wound healing in vitro and in vivo. Int J Mol Sci 26:901–906. https://doi.org/10.3892/ijmm_00000540
Choi MC, Jo J, Park J, Kang HK, Park Y (2019) NF-κB signaling pathways in osteoarthritic cartilage destruction. Cells. https://doi.org/10.3390/cells8070734
Chow YY, Chin K-Y (2020) The role of inflammation in the pathogenesis of osteoarthritis. Mediat Inflamm 2020:8293921–8293921. https://doi.org/10.1155/2020/8293921
Conaghan PG, Cook AD, Hamilton JA, Tak PP (2019) Therapeutic options for targeting inflammatory osteoarthritis pain. Nat Rev Rheumatol 15:355–363. https://doi.org/10.1038/s41584-019-0221-y
Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H (2020) Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. E Clin Med. https://doi.org/10.1016/j.eclinm.2020.100587
Daheshia M, Yao JQ (2008) The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol 35:2306–2312. https://doi.org/10.3899/jrheum.080346
Ding S-L, Pang Z-Y, Chen X-M, Li Z, Liu X-X, Zhai Q-L, Huang J-M, Ruan Z-Y (2020) Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes. J Inflamm 17:13. https://doi.org/10.1186/s12950-020-00242-8
El Moshy S, Radwan IA, Rady D, Abbass MMS, El-Rashidy AA, Sadek KM, Dörfer CE, Fawzy El-Sayed KM (2020) Dental stem cell-derived secretome/conditioned medium: the future for regenerative therapeutic applications. Stem Cells Int 2020:7593402. https://doi.org/10.1155/2020/7593402
Fan XL, Zhang Y, Li X, Fu QL (2020) Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cell Mol Life Sci CMLS 77:2771–2794. https://doi.org/10.1007/s00018-020-03454-6
Flannery CR, Little CB, Hughes CE, Curtis CL, Caterson B, Jones SA (2000) IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix Biol J Int Soc Matrix Biol 19:549–553. https://doi.org/10.1016/S0945-053X(00)00111-6
Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, Wolf C, Jacques C, Berenbaum F (2010) Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthr Cartil 18:106–116. https://doi.org/10.1016/j.joca.2009.08.019
García MD, Sáenz MT, Gómez MA, Fernández MA (1999) Topical antiinflammatory activity of phytosterols isolated from Eryngium foetidum on chronic and acute inflammation models. Phytother Res PTR 13:78–80. https://doi.org/10.1002/(SICI)1099-1573(199902)13:1%3c78::AID-PTR384%3e3.0.CO;2-F
Ghosh T, Maity TK, Singh J (2011) Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice. Orient Pharm Exp Med 11:41–49. https://doi.org/10.1007/s13596-011-0001-y
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma H-L, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434:644–648. https://doi.org/10.1038/nature03369
Goldring MB, Marcu KB (2009) Cartilage homeostasis in health and rheumatic diseases. Arthr Res Ther 11:224. https://doi.org/10.1186/ar2592
González-González A, García-Sánchez D, Dotta M, Rodríguez-Rey JC, Pérez-Campo FM (2020) Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine. World J Stem Cells 12:1529–1552. https://doi.org/10.4252/wjsc.v12.i12.1529
Haleagrahara N, Hodgson K, Miranda-Hernandez S, Hughes S, Kulur AB, Ketheesan N (2018) Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis. Inflammopharmacology 26:1219–1232. https://doi.org/10.1007/s10787-018-0464-2
Haque MN, Hannan MA, Dash R, Choi SM, Moon IS (2021) The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons. Phytomedicine 81:153415. https://doi.org/10.1016/j.phymed.2020.153415
Harrell CR, Fellabaum C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V (2019) Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome. Cells. https://doi.org/10.3390/cells8050467
Hashemi SM, Hassan ZM, Hossein-Khannazer N, Pourfathollah AA, Soudi S (2020) Investigating the route of administration and efficacy of adipose tissue-derived mesenchymal stem cells and conditioned medium in type 1 diabetic mice. Inflammopharmacology 28:585–601. https://doi.org/10.1007/s10787-019-00661-x
Huang X, Xi Y, Pan Q, Mao Z, Zhang R, Ma X, You H (2018) Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes. Biomed Pharmacother 107:433–439. https://doi.org/10.1016/j.biopha.2018.07.161
Jenei-Lanzl Z, Meurer A, Zaucke F (2019) Interleukin-1β signaling in osteoarthritis – chondrocytes in focus. Cell Signal 53:212–223. https://doi.org/10.1016/j.cellsig.2018.10.005
Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS (2014) Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells (dayton, Ohio) 32:1254–1266. https://doi.org/10.1177/0363546517716641
Joseph A, Baiju I, Bhat IA, Pandey S, Bharti M, Verma M, Pratap Singh A, Ansari MM, Chandra V, Saikumar G, Amarpal, and G. Taru Sharma. (2020) Mesenchymal stem cell-conditioned media: A novel alternative of stem cell therapy for quality wound healing. J Cell Physiol 235:5555–5569. https://doi.org/10.1002/jcp.29486
Kangari P, Talaei-Khozani T, Razeghian-Jahromi I, Razmkhah M (2020) Mesenchymal stem cells: amazing remedies for bone and cartilage defects. Stem Cell Res Ther 11:492. https://doi.org/10.1186/s13287-020-02001-1
Kaur S, Bijjem KRV, Sharma PL (2011) Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. Inflammopharmacology 19:265. https://doi.org/10.1007/s10787-011-0090-8
Kay AG, Long G, Tyler G, Stefan A, Broadfoot SJ, Piccinini AM, Middleton J, Kehoe O (2017) Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis. Sci Rep 7:18019. https://doi.org/10.1038/s41598-017-18144-w
Kim WS, Park BS, Kim HK, Park JS, Kim KJ, Choi JS, Chung SJ, Kim DD, Sung JH (2008) Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci 49:133–142. https://doi.org/10.1016/j.jdermsci.2007.08.004
Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR (2005) Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage. Arthr Rheum 52:128–135. https://doi.org/10.1002/art.20776
Kojima K, Kawahata I, Izumi H, Yoshihara S-I, Oki K (2020) Intranasal administration of conditioned medium from cultured mesenchymal stem cells improves cognitive impairment in olfactory bulbectomized mice. Adv Alzheimer’s Dis 9:47. https://doi.org/10.4236/aad.2020.93004
Lee WS, Kim HJ, Kim KI, Kim GB, Jin W (2019a) Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: a phase IIb, randomized, placebo-controlled clinical trial. Stem Cells Transl Med 8:504–511. https://doi.org/10.1002/sctm.18-0122
Lee YS, Lee SY, Park SY, Lee SW, Hong KW, Kim CD (2019b) Cilostazol add-on therapy for celecoxib synergistically inhibits proinflammatory cytokines by activating IL-10 and SOCS3 in the synovial fibroblasts of patients with rheumatoid arthritis. Inflammopharmacology 27:1205–1216. https://doi.org/10.1007/s10787-019-00605-5
Li X, He P, Hou Y, Chen S, Xiao Z, Zhan J, Luo D, Gu M, Lin D (2019) Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes. Drug Dev Res 80:637–645. https://doi.org/10.1002/ddr.21541
Liu CC, Zhang Y, Dai BL, Ma YJ, Zhang Q, Wang Y, Yang H (2017) Chlorogenic acid prevents inflammatory responses in IL-1β-stimulated human SW-1353 chondrocytes, a model for osteoarthritis. Mol Med Rep 16:1369–1375. https://doi.org/10.3892/mmr.2017.6698
Madhira SL, Challa SS, Chalasani M, Nappanveethl G, Bhonde RR, Ajumeera R, Venkatesan V (2012) Promise(s) of mesenchymal stem cells as an in vitro model system to depict pre-diabetic/diabetic milieu in WNIN/GR-ob mutant rats. PLoS ONE 7:e48061. https://doi.org/10.1371/journal.pone.0048061
Montero-Vilchez T, Sierra-Sánchez Á, Sanchez-Diaz M, Quiñones-Vico MI, Sanabria-de-la-Torre R, Martinez-Lopez A, Arias-Santiago S (2021) Mesenchymal stromal cell-conditioned medium for skin diseases: a systematic review. Front Cell Develop Biol 9:1877. https://doi.org/10.3389/fcell.2021.654210
Oseni AO, Butler PE, Seifalian AM (2013) Optimization of chondrocyte isolation and characterization for large-scale cartilage tissue engineering. J Surg Res 181:41–48. https://doi.org/10.1016/j.joca.2013.03.018
Panda S, Jafri M, Kar A, Meheta BK (2009) Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma. Fitoterapia 80:123–126. https://doi.org/10.1016/j.fitote.2008.12.002
Pawitan JA (2014) Prospect of Stem Cell Conditioned Medium in Regenerative Medicine. Biomed Res Int 2014:965849. https://doi.org/10.1155/2014/965849
Pelletier J-P, Martel-Pelletier J, Abramson SB (2001) Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets. Arthr Rheum 44:1237–1247. https://doi.org/10.1002/1529-0131(200106)44:6%3c1237::AID-ART214%3e3.0.CO;2-F
Philp AM, Davis ET, Jones SW (2016) Developing anti-inflammatory therapeutics for patients with osteoarthritis. Rheumatology 56:869–881. https://doi.org/10.1093/rheumatology/kew278
Pragasam SSJ, Kotikalapudi N, Venkatesan V (2021) A novel therapeutic combination of mesenchymal stem cells and stigmasterol to attenuate osteoarthritis in rodent model system-a proof of concept study. Stem Cell Investig 8:5. https://doi.org/10.21037/sci-2020-048
Pragasam SSJ, Venkatesan V (2020) Metabolic syndrome predisposes to osteoarthritis: lessons from model system. Cartilage. https://doi.org/10.1177/1947603520980161
Ramu R, Shirahatti PS, Nayakavadi S, V. R, F. Zameer, B.L. Dhananjaya, and N. Prasad Mn. (2016) The effect of a plant extract enriched in stigmasterol and β-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats. Food Funct 7:3999–4011. https://doi.org/10.1039/C6FO00343E
Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J (2016) Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12:580–592. https://doi.org/10.1038/nrrheum.2016.136
Sagaradze G, Grigorieva O, Nimiritsky P, Basalova N, Kalinina N, Akopyan Z, Efimenko A (2019) Conditioned medium from human mesenchymal stromal cells: towards the clinical translation. Int J Mol Sci 20:1656. https://doi.org/10.3390/ijms20071656
Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H, Takigawa M (1998) Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem 123:431–439. https://doi.org/10.1210/endo.137.9.8756539
Satué M, Schüler C, Ginner N, Erben RG (2019) Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs. Sci Rep 9:10153. https://doi.org/10.1038/s41598-019-46554-5
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochem Biophys Acta 1813:878–888. https://doi.org/10.1016/j.bbamcr.2011.01.034
Shabbir A, Zisa D, Suzuki G, Lee T (2009) Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen. Ham H Physion Heart Circul Physiol 296:H1888-1897. https://doi.org/10.1152/ajpheart.00186.2009
Shiomi T, Lemaître V, D’Armiento J, Okada Y (2010) Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol Int 60:477–496. https://doi.org/10.1111/j.1440-1827.2010.02547.x
Simental-Mendía M, Lozano-Sepúlveda SA, Pérez-Silos V, Fuentes-Mera L, Martínez-Rodríguez HG, Acosta-Olivo CA, Peña-Martínez VM, Vilchez-Cavazos F (2020) Anti-inflammatory and anti-catabolic effect of non-animal stabilized hyaluronic acid and mesenchymal stem cell-conditioned medium in an osteoarthritis coculture model. Mol Med Rep 21:2243–2250. https://doi.org/10.3892/mmr.2020.11004
Sofi MS, Sateesh MK, Bashir M, Ganie MA, Nabi S (2018) Chemopreventive and anti-breast cancer activity of compounds isolated from leaves of Abrus precatorius L. 3 Biotech 8:371. https://doi.org/10.1007/s13205-018-1395-8
Song Y, Du H, Dai C, Zhang L, Li S, Hunter DJ, Lu L, Bao C (2018) Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections. Regen Med 13:295–307. https://doi.org/10.2217/rme-2017-0152
Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434:648–652. https://doi.org/10.1038/nature03417
Tong Z, Liu Y, Chen B, Yan L, Hao D (2017) Association between MMP3 and TIMP3 polymorphisms and risk of osteoarthritis. Oncotarget 8: 83563–83569 https://doi.org/10.18632/oncotarget.18745
Usha PR, Naidu MUR (2004) Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig 24:353–363. https://doi.org/10.2165/00044011-200424060-00005
van der Kraan PM, van den Berg WB (2012) Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarthr Cartil 20:223–232. https://doi.org/10.1016/j.joca.2011.12.003
Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R (2017) Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci 18:1852. https://doi.org/10.3390/ijms18091852
Walker CIB, Oliveira SM, Tonello R, Rossato MF, da Silva Brum E, Ferreira J, Trevisan G (2017) Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. Naunyn Schmiedebergs Arch Pharmacol 390:1163–1172. https://doi.org/10.1007/s00210-017-1416-x
Walter MN, Wright KT, Fuller HR, MacNeil S, Johnson WE (2010) Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res 316:1271–1281. https://doi.org/10.1016/j.yexcr.2010.02.026
Xing D, Wu J, Wang B, Liu W, Liu W, Zhao Y, Wang L, Li JJ, Liu A, Zhou Q, Hao J, Lin J (2020) Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. Int J Rheum Dis 23:778–787. https://doi.org/10.1111/1756-185X.13834
Yadav M, Parle M, Jindal DK, Dhingra S (2018) Protective effects of stigmasterol against ketamine-induced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice. Pharmacol Rep 70:591–599. https://doi.org/10.1016/j.pharep.2018.01.001
Yu W, Xu P, Huang G, Liu L (2018) Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis. Exp Ther Med 16:2119–2125. https://doi.org/10.3892/etm.2018.6412
Zhou BR, Xu Y, Guo SL, Xu Y, Wang Y, Zhu F, Permatasari F, Wu D, Yin ZQ, Luo D (2013) The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing. Biomed Res Int 2013:519126. https://doi.org/10.1155/2013/519126