Beneficial effects of Aloe vera in treatment of diabetes: Comparative in vivo and in vitro studies

Gerstein, 2007, Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies, Diabetes Res Clin Pract, 78, 305, 10.1016/j.diabres.2007.05.004 Giacco, 2010, Oxidative stress and diabetic complications, Circulation Res, 29, 1058, 10.1161/CIRCRESAHA.110.223545 Baynes, 1999, Role of oxidative stress in diabetic complications: a new perspective on an old paradigm, Diabetes, 48, 1, 10.2337/diabetes.48.1.1 Ajabnoor, 1990, Effect of aloes on blood glucose levels in normal and alloxan diabetic mice, J Ethnopharmacol, 28, 215, 10.1016/0378-8741(90)90031-N Can, 2004, Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models, Biol Pharm Bull, 27, 694, 10.1248/bpb.27.694 Boudreau, 2006, An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera, J Environ Sci Health Part C, 24, 103, 10.1080/10590500600614303 Rajasekaran, 2005, Modulatory effects of aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin, J Pharm Pharmacol, 57, 241, 10.1211/0022357055416 Robertson, 2010, Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric therapy, Discov Med, 9, 132 Hounsom, 1998, A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy, Diabetologia, 41, 839, 10.1007/s001250050996 Best, 2010, Electrophysiological effects of osmotic cell shrinkage in rat pancreatic β-cells, Islets, 2, 303, 10.4161/isl.2.5.12748 Lacy, 1967, Method for the isolation of intact islets of Langerhans from the rat pancreas, Diabetes, 16, 35, 10.2337/diab.16.1.35 Cocchetto, 1983, Methods for vascular access and collection of body fluids from the laboratory rat, J Pharm Sci, 72, 465, 10.1002/jps.2600720503 Trinder, 1969, Determination of blood glucose using 4-amino phenazone as oxygen acceptor, J Clin Pathol, 22, 246, 10.1136/jcp.22.2.246-b King, 2002, Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats, Diabetes Technol Ther, 4, 479, 10.1089/152091502760306562 Mihara, 1978, Determination of ginsenosides precursor in tissues by thiobarbituric acid test, Anal Biochem, 86, 271, 10.1016/0003-2697(78)90342-1 Marklund, 1974, Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur J Biochem, 47, 469, 10.1111/j.1432-1033.1974.tb03714.x Beutler, 1963, Improved method for the determination of blood glutathione, J Lab Clin Med, 61, 882 Jain, 2010, Aloe vera gel alleviates cardiotoxicity in streptozotocin-induced diabetes in rats, J Pharm Pharmacol, 62, 115, 10.1211/jpp.62.01.0013 Kim, 2009, Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus, Phytomedicine, 16, 856, 10.1016/j.phymed.2009.02.014 Kim, 2009, Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis, J Pharmacol Sci, 109, 119, 10.1254/jphs.08189FP Norikura, 2002, Protective effect of aloe extract against the cytotoxicity of 1,4-naphthoquinone in isolated rat hepatocytes involves modulations in cellular thiol levels, Pharmacol Toxicol, 90, 278, 10.1034/j.1600-0773.2002.900508.x Saada, 2003, Effectiveness of aloe vera on the antioxidant status of different tissues in irradiated rats, Pharmazie, 58, 929 Singh, 2000, Chemomodulatory action of aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice, Phytomedicine, 7, 209, 10.1016/S0944-7113(00)80006-9 Takayanagi, 2011, Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus, J Clin Biochem Nutr, 48, 72, 10.3164/jcbn.11-014FR Grimble, 2002, Inflammatory status and insulin resistance, Curr Opin Clin Nutr Metab Care, 5, 551, 10.1097/00075197-200209000-00015 Ding, 2008, Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway, Eur J Pharmacol, 590, 377, 10.1016/j.ejphar.2008.06.044 Davis, 1994, Anti-inflammatory and wound healing activity of a growth substance in aloe vera, J Am Pod Med Ass, 84, 77, 10.7547/87507315-84-2-77 Hutter, 1996, Anti-inflammatory C-Glucosyl chromone from Aloe barbadensis, J Nat Prod, 59, 541, 10.1021/np9601519 Sudha, 2011, Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants, BMC Complement Altern Med, 11, 5, 10.1186/1472-6882-11-5