Bacterial resistances to inorganic mercury salts and organomercurials

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Barrineau, 1984, The DNA sequence of the mercury resistance operon of IncFII plasmid R100, J. Mol. Appl. Genet, 2, 601

Begley, 1986, Bacterial organomercurial lyase: overproduction, isolation, and characterization, Biochemistry, 25, 7086, 10.1021/bi00370a063

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Brown, 1983, Nucleotide sequence of a gene from the Pseudomonas transposon Tn501 encoding mercuric reductase, Biochemistry, 22, 4089, 10.1021/bi00286a015

Brown, 1986, The nucleotide sequence of the mercuric resistance operons of plasmids R100 and transposon Tn501: Further evidence for mer genes which enhance the activity of the mercuric ion detoxification system, Mol. Gen. Genet, 202, 143, 10.1007/BF00330531

Distefano, 1989, Mutagenesis of the redox-active disulfide in mercuric ion reductase: Catalysis by mutant enzymes restricted to flavin redox chemistry, Biochemistry, 28, 1168, 10.1021/bi00429a035

Distefano, 1990, Active site mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from adjacent subunit: Evidence from in vivo and in vitro heterodimer formation, Biochemistry, 29, 2703, 10.1021/bi00463a013

Foster, 1987, The genetics and biochemistry of mercury resistance, CRC Crit. Rev. Microbiol, 15, 117, 10.3109/10408418709104455

Foster, 1985, Identification of the merR gene of R100-1 by using merlac gene and operon fusions, J. Bacteriol, 163, 1153, 10.1128/JB.163.3.1153-1157.1985

Foster, 1985, Some mercurial resistance plasmids from different incompatibility groups specify merR regulatory functions that both repress and induce the mer operon of plasmid R100, J. Bacteriol, 162, 773, 10.1128/JB.162.2.773-776.1985

Foster, 1979, Deletions in the r-determinant mer region of plasmid R-100 selected for loss of mercury hypersensitivity, J. Bacteriol, 140, 301, 10.1128/JB.140.1.301-305.1979

Foster, 1979, Transposon A-generated mutations in the mercuric resistance genes of plasmid R100-1, J. Bacteriol, 140, 167, 10.1128/JB.140.1.167-181.1979

Fox, 1982, Mercuric reductase: Purification and characterization of a transposon-encoded flavoprotein containing oxidation-reduction-active disulfide, J. Biol. Chem, 257, 2498, 10.1016/S0021-9258(18)34951-2

Fox, 1983, Mercuric reductase: Homology to glutathione reductase and lipoamide dehydrogenase—iodoacetamide alkylation and sequence of active site peptide, Biochemistry, 22, 4082, 10.1021/bi00286a014

Frantz, 1990, DNA distortion accompanies transcriptional activation by the metal-responsive gene-regulatory protein MerR, Biochemistry, 29, 4747, 10.1021/bi00472a001

Gilbert, 1988, The distribution and divergence of DNA sequences related to the Tn21 and Tn501mer operons, Plasmid, 20, 127, 10.1016/0147-619X(88)90015-7

Griffin, 1987, Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358, 84, 3112

Helmann, 1990, The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metalbridged dimer, Science, 247, 946, 10.1126/science.2305262

Helmann, 1990, Regulation of gene expression by mercury, Adv. Inorg. Biochem, 8, 33

Helmann, 1989, Homologous metalloregulatory proteins from both Gram-positive and Gram-negative bacteria control transcription of mercury resistance operons, J. Bacteriol, 171, 222, 10.1128/jb.171.1.222-229.1989

Heltzel, 1987, Overexpression and DNA-binding properties of the mer-encoded regulatory protein from plasmid NR1 (Tn21), J. Bacteriol, 169, 3379, 10.1128/jb.169.7.3379-3384.1987

Heltzel, 1990, Activator-dependent preinduction of σ-70 RNA polymerase at the metal-regulated mer promoter, Biochemistry, 29, 9572, 10.1021/bi00493a011

Kusano, 1990, Constitutive synthesis of a transport function encoded by the Thiobacillus ferrooxidansmerC gene cloned in Escherichia coli, J. Bacteriol, 172, 2688, 10.1128/jb.172.5.2688-2692.1990

Laddaga, 1987, Nucleotide sequence and expression of the mercurial resistance operon from Staphylococcus aureus plasmid pI258, 84, 5106

Lund, 1987, Role of merT and merP gene products of transposon Tn501 in the induction and expression of resistance to mercuric ions, Gene, 52, 207, 10.1016/0378-1119(87)90047-3

Lund, 1989, Regulation of transcription in Escherichia coli from the mer and merR promoters in the transposon Tn501, J. Mol. Biol, 205, 343, 10.1016/0022-2836(89)90345-8

Lund, 1989, Up-promoter mutations in positively-regulated mer promoter of Tn501, Nucleic Acids Res, 17, 5517, 10.1093/nar/17.14.5517

Lund, 1986, Transcriptional regulation of the mercury-resistance genes of transposon Tn501, J. Gen. Microbiol, 132, 465

Miller, 1986, Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction, J. Biol. Chem, 261, 8081, 10.1016/S0021-9258(19)83876-0

Miller, 1990, Use of a site-directed triple mutant to trap intermediates: Demonstration that the flavin C(4a)-thiol aduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase, Biochemistry, 29, 2831, 10.1021/bi00463a028

Miller, 1991, Communication between the active sites in dimeric mercuric ion reductase: An alternating sites hypothesis for catalysis, Biochemistry, 30, 2600, 10.1021/bi00224a006

Miller, 1989, Evidence for participation of Cys558 and Cys559 at the active site of mercuric reductase, Biochemistry, 28, 1194, 10.1021/bi00429a037

Misra, 1984, Mercuric ion reductase operons of the plasmid R100 and transposon Tn501: The beginning of the operon including the regulatory region and the first two structural genes, 84, 5975

Misra, 1985, Mercuric reductase structural genes from plasmid R100 and transposon Tn501: Functional domains of the enzyme, Gene, 34, 253, 10.1016/0378-1119(85)90134-9

Moore, 1989, Purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from Bacillus sp. strain RC607, J. Biol. Chem, 264, 14386, 10.1016/S0021-9258(18)71690-6

Moore, 1989, Mutagenesis of the N- and C-terminal cysteine pairs of Tn501 mercuric ion reductase: Consequences for bacterial detoxification of mercurials, Biochemistry, 28, 1183, 10.1021/bi00429a036

Mukhopadhyay, 1991, Purification and functional characterization of MerD: A co-regulator of the mercury resistance operon in Gram-negative bacteria, J. Biol. Chem, 266, 18538, 10.1016/S0021-9258(18)55095-X

Nakahara, 1979, Hypersensitivity to Hg2+ and hyperbinding activity associated with cloned fragments of the mercurial resistance operon of plasmid NR1, J. Bacteriol, 140, 161, 10.1128/JB.140.1.161-166.1979

Natan, 1990, Solid-state 199Hg nuclear magnetic resonance as a probe of coordination number and geometry in Hg(II) complexes, J. Am. Chem. Soc, 112, 3255, 10.1021/ja00164a080

NiBhriain, 1983, Tn5 insertion mutations in the mercuric ion resistance genes derived from plasmid R100-1, J. Bacteriol, 155, 690, 10.1128/JB.155.2.690-703.1983

Nucifora, 1989, Mercury operon regulation by the merR gene of the organomercurial resistance system of plasmid pDU1358, J. Bacteriol, 171, 4241, 10.1128/jb.171.8.4241-4247.1989

Nucifora, 1989, Down regulation of mer operon function by the product of the merD gene of plasmid pDU1358, Mol. Gen. Genet, 220, 69, 10.1007/BF00260858

Ogawa, 1984, Physical and genetic map of the organomercury resistance (Omr) and inorganic mercury resistance (Hgr) loci of the IncM plasmid R831b, Gene, 32, 311, 10.1016/0378-1119(84)90006-4

O'Halloran, 1989, Metalloregulatory proteins: Metal responsive molecular switches governing gene expression, 105

O'Halloran, 1989, The merR heavy metal receptor mediates positive activation in a topologically novel transcription complex, Cell, 56, 119, 10.1016/0092-8674(89)90990-2

O'Halloran, 1987, Metalloregulatory DNA-binding protein encoded by the merR gene: Isolation and characterization, Science, 235, 211, 10.1126/science.3798107

Parkhill, 1990, Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501: The nineteen base-pair spacer is essential for normal induction of the promoter by MerR, Nucleic Acids Res, 18, 5157, 10.1093/nar/18.17.5157

Ralston, 1990, Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction, Adv. Inorg. Biochem, 8, 1

Ralston, 1990, Ultrasensitivity and heavy metal selectivity of the allosterically modulated MerR transcription complex, 87, 3846

Rinderle, 1983, Mercuric reductase from R-plasmid NR1: Characterization and mechanistic study, Biochemistry, 622, 869, 10.1021/bi00273a025

Ross, 1989, Genetic analysis of transcriptional activation and repression in the Tn21 mer operon, J. Bacteriol, 171, 4009, 10.1128/jb.171.7.4009-4018.1989

Sahlman, 1984, The reaction between NADPH and mercuric reductase from Pseudomonas aeruginosa. 1, J. Biol. Chem, 259, 12403, 10.1016/S0021-9258(18)90760-X

Schiering, 1991, Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607, Nature (London), 352, 168, 10.1038/352168a0

Schottel, 1978, The mercuric and organomercurial detoxifying enzymes from a plasmidbearing strain of Escherichia coli, J. Biol. Chem, 253, 4341, 10.1016/S0021-9258(17)34725-7

Schultz, 1985, Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase, Biochemistry, 24, 6840, 10.1021/bi00345a016

Shewchuck, 1989, Transcriptional switching by the MerR protein: Activation and repression mutants implicate distinct DNA and mercury(II) binding domains, Biochemistry, 28, 2340, 10.1021/bi00431a053

Shewchuck, 1989, Mutagenesis of the cysteines in the metalloregulatory protein MerR indicates that a metal-bridged dimmer activates transcription, Biochemistry, 28, 6140, 10.1021/bi00441a002

Silver, 1991, Bacterial heavy metal resistance systems and possibility of bioremediation, 265

Silver, 1990, Molecular genetics of heavy metal resistance systems of Staphylococcus plasmids, 531

Silver, 1988, Plasmidmediated heavy metal resistances, Annu. Rev. Microbiol, 42, 717, 10.1146/annurev.mi.42.100188.003441

Skinner, 1991, Transcriptional analysis of the Staphylococcus aureus plasmid pI258 mercury resistance determinant, J. Bacteriol, 173, 5234, 10.1128/jb.173.16.5234-5238.1991

Summers, 1986, Organization, expression, and evolution of genes for mercury resistance, Annu. Rev. Microbiol, 40, 607, 10.1146/annurev.mi.40.100186.003135

Walsh, 1988, Molecular basis of bacterial resistance to organomercurial and inorganic mercury salts, FASEB J, 2, 124, 10.1096/fasebj.2.2.3277886

Walts, 1988, Bacterial organomercurial lyase: Novel enzymatic protonolysis of organostannanes, J. Am. Chem. Soc, 110, 1950, 10.1021/ja00214a047

Wang, 1989, Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury-resistance, J. Bacteriol, 171, 83, 10.1128/jb.171.1.83-92.1989

Watton, 1990, Trigonal mercuric complex of an aliphatic thiolate: A spectroscopic and structural model for the receptor site in the Hg(II) biosensor MerR, J. Am. Chem. Soc, 112, 2824, 10.1021/ja00163a067

Witte, 1986, Resistance to mercury and to cadmium in chromosomally resistant Staphylococcus aureus, Antimicrob. Agents Chemother, 29, 663, 10.1128/AAC.29.4.663

Wright, 1990, Coordination chemistry of the Hg-MerR metalloregulatory protein: evidence for a novel tridentate Hg-cysteine receptor site, J. Am. Chem. Soc, 112, 2434, 10.1021/ja00162a062