Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease

Journal of Translational Autoimmunity - Tập 4 - Trang 100078 - 2021
Michael Battaglia1, Lee Ann Garrett-Sinha1
1Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14203, USA

Tài liệu tham khảo

Long, 2016, The critical role of epigenetics in systemic lupus erythematosus and autoimmunity, J. Autoimmun., 74, 118, 10.1016/j.jaut.2016.06.020 Legorreta-Haquet, 2016, Function of treg cells decreased in patients with systemic lupus erythematosus due to the effect of prolactin, Medicine (Baltim.), 95 Kleczynska, 2011, Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus, Folia Histochem. Cytobiol., 49, 646, 10.5603/FHC.2011.0088 Streicher, 2014, The plasma cell signature in autoimmune disease, Arthritis Rheum., 66, 173, 10.1002/art.38194 Shah, 2010, Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus, Arthritis Res. Ther., 12, 10.1186/ar2996 Kim, 2018, Follicular helper T cells in systemic lupus erythematosus, Front. Immunol., 9, 1793, 10.3389/fimmu.2018.01793 Li, 2007, Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes, Clin. Exp. Immunol., 147, 60, 10.1111/j.1365-2249.2006.03251.x Witte, 2000, Rheumatoid factors in systemic lupus erythematosus: association with clinical and laboratory parameters. SLE study group, Rheumatol. Int., 19, 107, 10.1007/s002960050112 Han, 2015, Mechanisms of autoantibody production in systemic lupus erythematosus, Front. Immunol., 6, 228, 10.3389/fimmu.2015.00228 Truedsson, 2007, Complement deficiencies and systemic lupus erythematosus, Autoimmunity, 40, 560, 10.1080/08916930701510673 Grondal, 2000, Cytokine production, serum levels and disease activity in systemic lupus erythematosus, Clin. Exp. Rheumatol., 18, 565 Lourenco, 2009, Cytokines in systemic lupus erythematosus, Curr. Mol. Med., 9, 242, 10.2174/156652409787847263 Howe, 2019, Anti-cytokine autoantibodies in systemic lupus erythematosus, Cells, 9 Stojan, 2018, Epidemiology of systemic lupus erythematosus: an update, Curr. Opin. Rheumatol., 30, 144, 10.1097/BOR.0000000000000480 Anders, 2020, Lupus nephritis, Nat Rev Dis Primers, 6, 7, 10.1038/s41572-019-0141-9 Mok, 2018, Effect of immunosuppressive therapies on survival of systemic lupus erythematosus: a propensity score analysis of a longitudinal cohort, Lupus, 27, 722, 10.1177/0961203317739129 Bharath, 2019, Mortality in systemic lupus erythematosus at a teaching hospital in India: a 5-year retrospective study, J. Fam. Med. Prim. Care, 8, 2511, 10.4103/jfmpc.jfmpc_362_19 Li, 2013, Biomarker profiling for lupus nephritis, Dev. Reprod. Biol., 11, 158 Chiu, 2012, Increased risk of ischemic stroke in patients with systemic lupus erythematosus: a nationwide population-based study, Intern. Med., 51, 17, 10.2169/internalmedicine.51.6154 Tsukamoto, 2020, Subarachnoid hemorrhage after ischemic stroke associated with systemic lupus erythematosus and antiphospholipid syndrome, World Neurosurg, 136, 248, 10.1016/j.wneu.2020.01.030 Mimori, 2000, Subarachnoid hemorrhage and systemic lupus erythematosus, Lupus, 9, 521, 10.1177/096120330000900708 J, 2007, Baizabal Carvallo, C. Cantu Brito, B. Estanol, G. S. Garcia Ramos. Subarachnoid hemorrhage as a complication of systemic lupus erythematosus, Cerebrovasc. Dis., 24, 301, 10.1159/000105684 Duarte-Delgado, 2019, Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus, Autoimmun. Rev., 18, 426, 10.1016/j.autrev.2018.12.004 Tselios, 2017, Of systemic lupus erythematosus, Curr. Rheumatol. Rev., 13, 206, 10.2174/1573397113666170704102444 Munguia-Realpozo, 2019, Systemic lupus erythematosus and hypertension, Autoimmun. Rev., 18, 102371, 10.1016/j.autrev.2019.102371 Cervera, 1999, Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1,000 patients. European Working Party on Systemic Lupus Erythematosus, Medicine (Baltim.), 78, 167, 10.1097/00005792-199905000-00003 Kim, 1999, Causes of death in Korean patients with systemic lupus erythematosus: a single center retrospective study, Clin. Exp. Rheumatol., 17, 539 Kang, 2011, The causes of death in Korean patients with systemic lupus erythematosus over 11 years, Lupus, 20, 989, 10.1177/0961203311402245 Jacobsen, 1999, Mortality and causes of death of 513 Danish patients with systemic lupus erythematosus, Scand. J. Rheumatol., 28, 75, 10.1080/030097499442522 Adwan, 2020, In-hospital mortality in patients with systemic lupus erythematosus: a study from Jordan, Rheumatol. Int., 2002 Fei, 2014, Death causes and pathogens analysis of systemic lupus erythematosus during the past 26 years, Clin. Rheumatol., 33, 57, 10.1007/s10067-013-2383-3 Tsai, 2020, Septicaemia is associated with increased disease activity and mortality in systemic lupus erythematosus: a retrospective analysis from Taiwan, Lupus, 29, 191, 10.1177/0961203319899162 Liang, 2019, Causes and factors associated with frequent hospitalization in Chinese patients with systemic lupus erythematosus: an ambispective cohort study, Med. Sci. Mon. Int. Med. J. Exp. Clin. Res., 25, 8061 Anastasiou, 2018, Immunosuppressant use and hospitalisations in adult patients with systemic lupus erythematosus admitted to a tertiary academic medical centre, Lupus Sci Med, 5, 10.1136/lupus-2017-000249 Taneja, 2014, Arthritis susceptibility and the gut microbiome, FEBS Lett., 588, 4244, 10.1016/j.febslet.2014.05.034 Abdelhamid, 2018, Retinoic acid, leaky gut, and autoimmune diseases, Nutrients, 10 Peters, 2019, Autoimmune diabetes mellitus and the leaky gut, Proc. Natl. Acad. Sci. U. S. A., 116, 14788, 10.1073/pnas.1909224116 Shi, 2014, The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs, PloS One, 9 Issara-Amphorn, 2018, The synergy of endotoxin and (1-->3)-beta-D-glucan, from gut translocation, worsens sepsis severity in a lupus model of fc gamma receptor IIb-deficient mice, J Innate Immun, 10, 189 Manfredo Vieira, 2018, Translocation of a gut pathobiont drives autoimmunity in mice and humans, Science, 359, 1156, 10.1126/science.aar7201 Mu, 2017, Control of lupus nephritis by changes of gut microbiota, Microbiome, 5, 73, 10.1186/s40168-017-0300-8 Toral, 2019, Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus, Faseb. J., 33, 10005, 10.1096/fj.201900545RR Zegarra-Ruiz, 2019, A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity, Cell Host Microbe, 25, 113, 10.1016/j.chom.2018.11.009 Thim-Uam, 2020, Leaky-gut enhanced lupus progression in the Fc gamma receptor-IIb deficient and pristane-induced mouse models of lupus, Sci. Rep., 10, 777, 10.1038/s41598-019-57275-0 Arpaia, 2013, Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation, Nature, 504, 451, 10.1038/nature12726 Amoroso, 2020, The role of gut microbiota biomodulators on mucosal immunity and intestinal inflammation, Cells, 9 Haase, 2018, Impacts of microbiome metabolites on immune regulation and autoimmunity, Immunology, 154, 230, 10.1111/imm.12933 Lee, 2017, Microbiota in T-cell homeostasis and inflammatory diseases, Exp. Mol. Med., 49, 10.1038/emm.2017.36 Zhang, 2014, Dynamics of gut microbiota in autoimmune lupus, Appl. Environ. Microbiol., 80, 7551, 10.1128/AEM.02676-14 Luo, 2018, Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus, Appl. Environ. Microbiol., 84 Hugenholtz, 2018, Mouse models for human intestinal microbiota research: a critical evaluation, Cell. Mol. Life Sci., 75, 149, 10.1007/s00018-017-2693-8 Khan, 2019, Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome, Pathogens, 8 Shen, 2018, Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation, World J. Gastroenterol., 24, 5, 10.3748/wjg.v24.i1.5 Lopez, 2016, Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients, Sci. Rep., 6, 24072, 10.1038/srep24072 Tremaroli, 2012, Functional interactions between the gut microbiota and host metabolism, Nature, 489, 242, 10.1038/nature11552 Hevia, 2014, Intestinal dysbiosis associated with systemic lupus erythematosus, mBio, 5, 14, 10.1128/mBio.01548-14 He, 2016, Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus, Gut Pathog., 8, 64, 10.1186/s13099-016-0146-9 van der Meulen, 2019, Shared gut, but distinct oral microbiota composition in primary Sjogren’s syndrome and systemic lupus erythematosus, J. Autoimmun., 97, 77, 10.1016/j.jaut.2018.10.009 Li, 2019, Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus, Clin. Sci. (Lond.), 133, 821, 10.1042/CS20180841 Wei, 2019, Changes of intestinal flora in patients with systemic lupus erythematosus in northeast China, PloS One, 14 Li, 2020, Dysbiosis of oral microbiota is associated with systemic lupus erythematosus, Arch. Oral Biol., 113, 104708, 10.1016/j.archoralbio.2020.104708 Huang, 2020, Disordered cutaneous microbiota in systemic lupus erythematosus, J. Autoimmun., 108, 102391, 10.1016/j.jaut.2019.102391 O, 2019, Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal, Ann. Rheum. Dis., 947 Riddle, 2016, Status of vaccine research and development for Campylobacter jejuni, Vaccine, 34, 2903, 10.1016/j.vaccine.2016.02.080 Jiang, 2011, Beneficial effect of Eucommia polysaccharides on systemic lupus erythematosus-like syndrome induced by Campylobacter jejuni in BALB/c mice, Inflammation, 34, 402, 10.1007/s10753-010-9247-7 Henke, 2019, Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide, Proc. Natl. Acad. Sci. U. S. A., 116, 12672, 10.1073/pnas.1904099116 Joossens, 2011, Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives, Gut, 60, 631, 10.1136/gut.2010.223263 Hall, 2017, A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients, Genome Med., 9, 103, 10.1186/s13073-017-0490-5 Lopez, 2016, Intestinal dysbiosis in systemic lupus erythematosus: cause or consequence?, Curr. Opin. Rheumatol., 28, 515, 10.1097/BOR.0000000000000309 Mu, 2017, Antibiotics ameliorate lupus-like symptoms in mice, Sci. Rep., 7, 13675, 10.1038/s41598-017-14223-0 Maldonado, 1999, The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice, J. Immunol., 162, 6322, 10.4049/jimmunol.162.11.6322 Pandiyan, 2019, Microbiome dependent regulation of Tregs and Th17 cells in mucosa, Front. Immunol., 10, 426, 10.3389/fimmu.2019.00426 Johnson, 2015, Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice, Clin. Exp. Immunol., 181, 323, 10.1111/cei.12609 Hsu, 2017, Lactobacillus paracasei GMNL-32, Lactobacillus reuteri GMNL-89 and L. reuteri GMNL-263 ameliorate hepatic injuries in lupus-prone mice, Br. J. Nutr., 117, 1066, 10.1017/S0007114517001039 Tzang, 2017, Effects of oral Lactobacillus administration on antioxidant activities and CD4+CD25+forkhead box P3 (FoxP3)+ T cells in NZB/W F1 mice, Br. J. Nutr., 118, 333, 10.1017/S0007114517002112 Hu, 2017, Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in NZB/W F1 mice, PloS One, 12, 10.1371/journal.pone.0185098 Khorasani, 2019, Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model, J. Cell. Physiol., 234, 9778, 10.1002/jcp.27663 Mardani, 2018, In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics, J. Cell. Physiol., 234, 642, 10.1002/jcp.26819 Mu, 2019, Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota, Microbiome, 7, 105, 10.1186/s40168-019-0720-8 Sczesnak, 2011, The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment, Cell Host Microbe, 10, 260, 10.1016/j.chom.2011.08.005 Ivanov, 2009, Induction of intestinal Th17 cells by segmented filamentous bacteria, Cell, 139, 485, 10.1016/j.cell.2009.09.033 Koga, 2019, The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target, Expet Rev. Clin. Immunol., 15, 629, 10.1080/1744666X.2019.1593141 Gaboriau-Routhiau, 2009, The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses, Immunity, 31, 677, 10.1016/j.immuni.2009.08.020 Yin, 2013, Comparative analysis of the distribution of segmented filamentous bacteria in humans, mice and chickens, ISME J., 7, 615, 10.1038/ismej.2012.128 Tan, 2016, Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice, Proc. Natl. Acad. Sci. U. S. A., 113, E8141, 10.1073/pnas.1617460113 Van Praet, 2015, Commensal microbiota influence systemic autoimmune responses, EMBO J., 34, 466, 10.15252/embj.201489966 Tektonidou, 2015, Burden of serious infections in adults with systemic lupus erythematosus: a national population-based study, 1996-2011, Arthritis Care Res., 67, 1078, 10.1002/acr.22575 Yen, 2017, 46-Year trends in systemic lupus erythematosus mortality in the United States, 1968 to 2013: a nationwide population-based study, Ann. Intern. Med., 167, 777, 10.7326/M17-0102 Gomez-Puerta, 2015, Racial/Ethnic variation in all-cause mortality among United States medicaid recipients with systemic lupus erythematosus: a Hispanic and asian paradox, Arthritis Rheum., 67, 752, 10.1002/art.38981 Gladman, 2002, The nature and outcome of infection in systemic lupus erythematosus, Lupus, 11, 234, 10.1191/0961203302lu170oa Marcos, 2011, Epidemiology and clinical outcomes of bloodstream infections among lupus patients, Lupus, 20, 965, 10.1177/0961203311403345 Rua-Figueroa, 2020, Bacteremia in systemic lupus erythematosus in patients from a Spanish registry: risk factors, clinical and microbiological characteristics, and outcomes, J. Rheumatol., 47, 234, 10.3899/jrheum.180882 Dubula, 2015, Spectrum of infections and outcome among hospitalized South Africans with systemic lupus erythematosus, Clin. Rheumatol., 34, 479, 10.1007/s10067-014-2847-0 Martinez-Martinez, 2014, Factors associated with mortality and infections in patients with systemic lupus erythematosus with diffuse alveolar hemorrhage, J. Rheumatol., 41, 1656, 10.3899/jrheum.130927 Ruiz-Irastorza, 2009, Predictors of major infections in systemic lupus erythematosus, Arthritis Res. Ther., 11, 10.1186/ar2764 Oud, 2020, Epidemiology and outcomes of sepsis among hospitalizations with systemic lupus erythematosus admitted to the ICU: a population-based cohort study, J Intensive Care, 8, 3, 10.1186/s40560-019-0424-y Hsu, 2019, Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study, Arthritis Res. Ther., 21, 211, 10.1186/s13075-019-1997-5 Mok, 2012, Understanding lupus nephritis: diagnosis, management, and treatment options, Int J Womens Health, 4, 213, 10.2147/IJWH.S28034 Yu, 2018, Infections caused by extended-spectrum beta-lactamase producing Escherichia coli in systemic lupus erythematosus patients: prevalence, risk factors, and predictive model, BioMed Res. Int., 2018, 8296720, 10.1155/2018/8296720 Goldblatt, 2009, Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality, Lupus, 18, 682, 10.1177/0961203308101019 Horta-Baas, 2013, Central nervous system infection by Listeria monocytogenes in patients with systemic lupus erythematosus: analysis of 26 cases, including the report of a new case, Reumatol. Clínica, 9, 340, 10.1016/j.reuma.2013.04.011 Tobon, 2013, Listeria monocytogenes infection in patients with systemic lupus erythematosus, Clin. Rheumatol., S25, 10.1007/s10067-010-1416-4 Zhang, 2008, [A clinical study of tuberculosis infection in systemic lupus erythematosus], Zhonghua Nei Ke Za Zhi, 47, 808 Sayarlioglu, 2004, Tuberculosis in Turkish patients with systemic lupus erythematosus: increased frequency of extrapulmonary localization, Lupus, 13, 274, 10.1191/0961203303lu529xx Mitander, 2018, Complement consumption in systemic lupus erythematosus leads to decreased opsonophagocytosis in, Vitro. J Rheumatol, 45, 1557, 10.3899/jrheum.171325 Jung, 2019, Associated clinical factors for serious infections in patients with systemic lupus erythematosus, Sci. Rep., 9, 9704, 10.1038/s41598-019-46039-5 Liu, 2018, Infections in hospitalized lupus nephritis patients: characteristics, risk factors, and outcomes, Lupus, 27, 1150, 10.1177/0961203318768881 Lim, 2017, Severe infections in patients with lupus nephritis treated with immunosuppressants: A retrospective cohort study, Nephrology, 22, 478, 10.1111/nep.12809 Gencer, 2003, Undiagnosed systemic lupus erythematosus presenting with salmonella bacteremia: a case report and mini-review, Clin. Microbiol. Infect., 9, 572, 10.1046/j.1469-0691.2003.00604.x Yogi, 1989, The experimental inoculation with Mycobacterium leprae in autoimmune mice: results of MRL/lpr mice inoculated into the right hind foot (continued), Nippon. Rai Gakkai Zasshi, 58, 235, 10.5025/hansen1977.58.235 Li, 2019, Infection with opportunistic bacteria triggers severe pulmonary inflammation in lupus-prone mice, Mediat. Inflamm., 2019, 1701367, 10.1155/2019/1701367 Mehrad, 2006, The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections, J. Immunol., 176, 3233, 10.4049/jimmunol.176.5.3233 Waisberg, 2011, Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice, Proc. Natl. Acad. Sci. U. S. A., 108, 1122, 10.1073/pnas.1017996108 Otto, 2020, Staphylococci in the human microbiome: the role of host and interbacterial interactions, Curr. Opin. Microbiol., 53, 71, 10.1016/j.mib.2020.03.003 Oogai, 2011, Expression of virulence factors by Staphylococcus aureus grown in serum, Appl. Environ. Microbiol., 77, 8097, 10.1128/AEM.05316-11 Barrera-Vargas, 2014, Risk factors for drug-resistant bloodstream infections in patients with systemic lupus erythematosus, J. Rheumatol., 41, 1311, 10.3899/jrheum.131261 Al-Rayes, 2007, Systemic lupus erythematosus and infections: a retrospective study in Saudis, Lupus, 16, 755, 10.1177/0961203307079943 Sirobhushanam, 2019, Staphylococcus aureus colonization is increased on lupus skin lesions and is promoted by IFN-mediated barrier disruption, J. Invest. Dermatol. Bitschar, 2020, Staphylococcus aureus skin colonization is enhanced by the interaction of neutrophil extracellular traps with keratinocytes, J. Invest. Dermatol., 140, 1054, 10.1016/j.jid.2019.10.017 Hakkim, 2010, Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis, Proc. Natl. Acad. Sci. U. S. A., 107, 9813, 10.1073/pnas.0909927107 Mehraj, 2016, Epidemiology of Staphylococcus aureus nasal carriage patterns in the community, Curr. Top. Microbiol. Immunol., 398, 55 Conti, 2016, Association between Staphylococcus aureus nasal carriage and disease phenotype in patients affected by systemic lupus erythematosus, Arthritis Res. Ther., 18, 177, 10.1186/s13075-016-1079-x Hajialilo, 2015, Nasal carriage rate of Staphylococcus aureus among patients with systemic lupus erythematosus and its correlation with disease relapse, Egypt. Rheumatol., 37, 81, 10.1016/j.ejr.2014.06.006 Salinas-Carmona, 2009, Spontaneous arthritis in MRL/lpr mice is aggravated by Staphylococcus aureus and ameliorated by Nippostrongylus brasiliensis infections, Autoimmunity, 42, 25, 10.1080/08916930802228290 Bremell, 1990, Outbreak of spontaneous staphylococcal arthritis and osteitis in mice, Arthritis Rheum., 33, 1739, 10.1002/art.1780331120 Jenkinson, 1989, Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire, Eur. J. Immunol., 19, 2175, 10.1002/eji.1830191132 Chowdhary, 2012, Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus, J. Immunol., 189, 2054, 10.4049/jimmunol.1201097 Kim, 1991, Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment, J. Exp. Med., 174, 1431, 10.1084/jem.174.6.1431 Gonzalo, 1994, A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice, Clin. Immunol. Immunopathol., 71, 176, 10.1006/clin.1994.1069 Zhou, 1992, Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice, J. Exp. Med., 176, 1063, 10.1084/jem.176.4.1063 Janik, 2015, Staphylococcal enterotoxin B (SEB) induces memory CD4 T cell anergy in vivo and impairs recall immunity to unrelated antigens, J. Clin. Cell. Immunol., 6, 1 Watson, 2003, Staphylococcal enterotoxin B induces anergy to conventional peptide in memory T cells, Cell. Immunol., 222, 144, 10.1016/S0008-8749(03)00117-5 Huang, 2012, Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases, J. Microbiol. Immunol. Infect., 45, 350, 10.1016/j.jmii.2011.12.013 Tsao, 2002, Risk factors of mortality for salmonella infection in systemic lupus erythematosus, J. Rheumatol., 29, 1214 Gerona, 2009, Salmonella infections in patients with systemic lupus erythematosus: a case series, Int J Rheum Dis, 12, 319, 10.1111/j.1756-185X.2009.01440.x Wu, 2004, Osteomyelitis in patients with systemic lupus erythematosus, J. Rheumatol., 31, 1340 Huang, 2006, Septic arthritis in patients with systemic lupus erythematosus: salmonella and nonsalmonella infections compared, Semin. Arthritis Rheum., 36, 61, 10.1016/j.semarthrit.2006.04.003 Abramson, 1985, Salmonella bacteremia in systemic lupus erythematosus. Eight-year experience at a municipal hospital, Arthritis Rheum., 28, 75, 10.1002/art.1780280112 Matsiota-Bernard, 1996, Beneficial effect of Salmonella typhimurium infection and of immunoglobulins from S. typhimurium-infected mice on the autoimmune disease of (NZB x NZW) F1 mice, Clin. Exp. Immunol., 104, 228, 10.1046/j.1365-2249.1996.15724.x Gallo, 2015, Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity, Immunity, 42, 1171, 10.1016/j.immuni.2015.06.002 Kaper, 2004, Pathogenic Escherichia coli, Nat. Rev. Microbiol., 2, 123, 10.1038/nrmicro818 Luijten, 2014, Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections, Lupus, 23, 1512, 10.1177/0961203314543918 Wendling, 1998, Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp’s?, Biotherapy, 10, 223, 10.1007/BF02678300 Handley, 1996, Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL, Clin. Exp. Immunol., 103, 429, 10.1111/j.1365-2249.1996.tb08298.x Dhaher, 1997, The effect of OM-89 (Subreum) on the murine model of systemic lupus erythematosus MRL-lpr/lpr, Lupus, 6, 436, 10.1177/096120339700600504 Garcia-Guevara, 2018, Pneumonia in patients with systemic lupus erythematosus: epidemiology, microbiology and outcomes, Lupus, 27, 1953, 10.1177/0961203318799207 Schurder, 2018, Pneumococcal infection in patients with systemic lupus erythematosus, Joint Bone Spine, 85, 333, 10.1016/j.jbspin.2017.05.012 Goldblatt, 2009, Impaired C3b/iC3b deposition on Streptococcus pneumoniae in serum from patients with systemic lupus erythematosus, Rheumatology, 48, 1498, 10.1093/rheumatology/kep289 Einav, 2002, Complement C4 is protective for lupus disease independent of C3, J. Immunol., 168, 1036, 10.4049/jimmunol.168.3.1036 Lastoria, 2014, Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - part 1, An. Bras. Dermatol., 89, 205, 10.1590/abd1806-4841.20142450 Chai, 2018, Mycobacterium tuberculosis: an adaptable pathogen associated with multiple human diseases, Front Cell Infect Microbiol, 8, 158, 10.3389/fcimb.2018.00158 Lin, 2012, Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan, Rheumatol. Int., 32, 1669, 10.1007/s00296-011-1847-5 Mok, 2005, Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy, J. Rheumatol., 32, 609 Erdozain, 2006, High risk of tuberculosis in systemic lupus erythematosus?, Lupus, 15, 232, 10.1191/0961203306lu2289xx Gaitonde, 2002, Efficacy of isoniazid prophylaxis in patients with systemic lupus erythematosus receiving long term steroid treatment, Ann. Rheum. Dis., 61, 251, 10.1136/ard.61.3.251 Machado Ribeiro, 2015, Mycobacteria and autoimmunity, Lupus, 24, 374, 10.1177/0961203314559634 Hsieh, 2014, Leprosy mimicking lupus erythematosus, Dermatol. Sin., 32, 47, 10.1016/j.dsi.2013.01.004 Karadeniz, 2014, Lepromatous leprosy mimicking systemic lupus erythematosus: a clinical pathology conference held by the division of rheumatology at hospital for special surgery, HSS J., 10, 286, 10.1007/s11420-014-9405-9 Chodisetti, 2012, Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis, BMC Immunol., 13, 13, 10.1186/1471-2172-13-13 Pahari, 2017, Morbid sequences suggest molecular mimicry between microbial peptides and self-antigens: a possibility of inciting autoimmunity, Front. Microbiol., 8, 1938, 10.3389/fmicb.2017.01938 Res, 1988, Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis, Lancet, 2, 478, 10.1016/S0140-6736(88)90123-7 Ohosone, 1998, Spectrum and clinical significance of autoantibodies against transfer RNA, Arthritis Rheum., 41, 1625, 10.1002/1529-0131(199809)41:9<1625::AID-ART13>3.0.CO;2-D Marengo, 2008, Administration of M. leprae Hsp65 interferes with the murine lupus progression, PloS One, 3, 10.1371/journal.pone.0003025 Yagishita, 2020, Clinical features and prognosis of nocardiosis in patients with connective tissue diseases, Mod. Rheumatol., 1