Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells

Cell Stem Cell - Tập 10 - Trang 570-582 - 2012
Margaret A. Young1, David E. Larson2, Chiao-Wang Sun3, Daniel R. George1, Li Ding2,4, Christopher A. Miller2, Ling Lin2, Kevin M. Pawlik3, Ken Chen5, Xian Fan2, Heather Schmidt2, Joelle Kalicki-Veizer2, Lisa L. Cook2, Gary W. Swift2, Ryan T. Demeter2, Michael C. Wendl2,4,6, Mark S. Sands1, Elaine R. Mardis2,4,7, Richard K. Wilson2,4,7, Tim M. Townes3
1Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University, St Louis, MO 63110, USA
2The Genome Institute, Washington University, St. Louis, MO 63110, USA
3University of Alabama at Birmingham, Birmingham, AL 35294, USA
4Department of Genetics, Washington University, St Louis, MO 63110, USA
5Department of Bioinformatics and Computational Biology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
6Department of Mathematics, Washington University, St Louis, MO 63110, USA
7Siteman Cancer Center, Washington University, St Louis, MO 63110, USA

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