Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Abdhul, 2015, Bacteriocinogenic potential of a probiotic strain Bacillus coagulans [BDU3] from Ngari., Int. J. Biol. Macromol., 79, 800, 10.1016/j.ijbiomac.2015.06.005

Abhari, 2016, The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats., Food Nutr. Res., 60, 10.3402/fnr.v60.30876

Adami, 1999, Occurrence of selected bacterial groups in the faeces of piglets fed with Bacillus coagulans as probiotic., J. Basic Microbiol., 39, 3, 10.1002/(SICI)1521-4028(199903)39:1<3::AID-JOBM3>3.0.CO;2-O

Adewumi, 2014, Genome subtyping of autochthonous Bacillus species isolated from Iru, a fermented Parkia biglobosa seed., Food Biotechnol., 28, 250, 10.1080/08905436.2014.931866

Alkaya, 2016, Clinical effects of probiotics containing Bacillus species on gingivitis: a pilot randomized controlled trial., J. Periodontal. Res., 52, 497, 10.1111/jre.12415

Alou, 2015, Bacillus rubiinfantis sp. nov. strain mt2T, a new bacterial species isolated from human gut, New Microbes New Infect., 8, 51, 10.1016/j.nmni.2015.09.008

Altmeyer, 2014, Impact of a probiotic Bacillus cereus strain on the jejunal epithelial barrier and on the NKG2D expressing immune cells during the weaning phase of piglets., Vet. Immunol. Immunopathol., 161, 57, 10.1016/j.vetimm.2014.07.001

Angmo, 2016, Probiotic characterization of lactic acid bacteria isolated from fermented foods and beverage of Ladakh., LWT Food Sci. Technol., 66, 428, 10.1016/j.lwt.2015.10.057

Ash, 1991, Phylogenetic heterogeneity of the genus Bacillus revealed by comparative analysis of small-subunit-ribosomal RNA sequences., Lett. Appl. Microbiol., 13, 202, 10.1111/j.1472-765X

Bader, 2012, Spore-forming bacteria and their utilisation as probiotics., Benef. Microbes, 3, 67, 10.3920/BM2011.0039

Beaumont, 2002, Flavouring composition prepared by fermentation with Bacillus spp., Int. J. Food Microbiol., 75, 189, 10.1016/S0168-1605(01)00706-1

Berthold-Pluta, 2015, The effect of selected factors on the survival of Bacillus cereus in the human gastrointestinal tract., Microb. Pathog., 82, 7, 10.1016/j.micpath.2015.03.015

Bohm, 2015, Massive horizontal gene transfer, strictly vertical inheritance and ancient duplications differentially shape the evolution of Bacillus cereus enterotoxin operons hbl, cytK and nhe., BMC Evol. Biol., 15, 10.1186/s12862-015-0529-4

Butel, 2014, Probiotics, gut microbiota and health., Med. Mal. Infect., 44, 1, 10.1016/j.medmal.2013.10.002

Cai, 2017, Use of Bacillus amyloliquefaciens HZ-12 for high-level production of the blood glucose lowering compound, 1-deoxynojirimycin (DNJ), and nutraceutical enriched soybeans via fermentation., Appl. Biochem. Biotechnol., 181, 1108, 10.1007/s12010-016-2272-8

Casula, 2002, Bacillus probiotics: spore germination in the gastrointestinal tract., Appl. Environ. Microbiol., 68, 2344, 10.1128/AEM.68.5.2344-2352.2002

Chantawannakul, 2002, Characterization of proteases of Bacillus subtilis strain 38 isolated from traditionally fermented soybean in northern Thailand., Sci. Asia, 28, 241, 10.2306/scienceasia1513-1874.2002.28.241

Choi, 2016, Cheonggukjang, a soybean paste fermented with B. licheniformis 67 prevents weight gain and improves glycemic control in high fat diet induced obese mice., J. Clin. Biochem. Nutr., 59, 31, 10.3164/jcbn.15-30

Cutting, 2011, Bacillus probiotics., Food Microbiol., 28, 214, 10.1016/j.fm.2010.03.007

Di Caro, 2005, Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis., Eur. J. Gastroenterol. Hepatol., 17, 951, 10.1097/00042737-200509000-00011

Doron, 2015, Risk and safety of probiotics., Clin. Infect. Dis., 60, S129, 10.1093/cid/civ085

Drago, 2013, Microbiological evaluation of commercial probiotic products available in the United States in 2009., J. Chemother., 22, 373, 10.1179/joc.2010.22.6.373

Duc, 2004, Characterization of Bacillus probiotics available for human use., Appl. Environ. Microbiol., 70, 2161, 10.1128/AEM.70.4.2161-2171.2004

Dudonné, 2015, Modulatory effects of a cranberry extract co-supplementation with Bacillus subtilis CU1 probiotic on phenolic compounds bioavailability and gut microbiota composition in high-fat diet-fed mice., Pharma Nutr., 3, 89, 10.1016/j.phanu.2015.04.002

Earl, 2012, Whole-genome sequences of Bacillus subtilis and close relatives., J. Bacteriol., 194, 2378, 10.1128/JB.05675-11

Ellekilde, 2014, Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice., Sci. Rep., 4, 10.1038/srep05922

Endres, 2009, Safety assessment of a proprietary preparation of a novel probiotic, Bacillus coagulans, as a food ingredient., Food Chem. Toxicol., 47, 1231, 10.1016/j.fct.2009.02.018

Fakhry, 2008, Characterization of spore forming Bacilli isolated from the human gastrointestinal tract., J. Appl. Microbiol., 105, 2178, 10.1111/j.1365-2672.2008.03934.x

Fan, 2017, Bacillus amyloliquefaciens, Bacillus velezensis and Bacillus siamensis form an operational group B. amyloliquefaciens within the B. subtilis species complex., Front. Microbiol., 8, 10.3389/fmicb.2017.00022

2001, Health and Nutritional Properties of Probiotics in Food Including Powder Milk With Live Lactic Acid Bacteria.

2002, Guidelines for the Evaluation of Probiotics in Food. Food and Agriculture Organization of the United Nations and World Health Organization Working Group Report.

Foligné, 2012, Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice., Clin. Nutr., 31, 987, 10.1016/j.clnu.2012.05.016

Fujiya, 2007, The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter., Cell Host Microbe, 1, 299, 10.1016/j.chom.2007.05.004

Ghani, 2013, Isolation and characterization of different strains of Bacillus licheniformis for the production of commercially significant enzymes., Pak. J. Pharm. Sci., 26, 691

Ghelardi, 2015, Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation., J. Appl. Microbiol., 119, 552, 10.1111/jam.12848

Ghoneim, 2016, Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats., BMC Complement. Altern. Med., 16, 10.1186/s12906-016-1093-1

Gobi, 2016, GFP tagged Vibrio parahaemolyticus Dahv2 infection and the protective effects of the probiotic Bacillus licheniformis Dahb1 on the growth, immune and antioxidant responses in Pangasius hypophthalmus., Fish Shellfish Immunol., 52, 230, 10.1016/j.fsi.2016.03.006

Green, 1999, Characterization of two bacillus probiotics., Appl. Environ. Microbiol., 65, 4288, 10.1128/AEM.65.9.4288-4291.1999

Guo, 2013, Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomized controlled trials., Nutr. Metab. Cardiovasc. Dis., 21, 844, 10.1016/j.numecd.2011.04.008

Haldar, 2016, Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model., Vet. World, 9, 10.14202/vetworld.2016.766-772

Hoffman, 1995, The anaerobic life of Bacillus subtilis: cloning of the genes encoding the respiratory nitrate reductase system., FEMS Microbiol. Lett., 131, 219, 10.1111/j.1574-6968.1995.tb07780.x

Hong, 2005, The use of bacterial spore formers as probiotics., FEMS Microbiol. Rev., 29, 813, 10.1016/j.femsre.2004.12.001

Hong, 2008, The safety of Bacillus subtilis and Bacillus indicus as food probiotics., J. Appl. Microbiol., 105, 510, 10.1111/j.1365-2672.2008.03773.x

Hong, 2009, Bacillus subtilis isolated from the human gastrointestinal tract., Res. Microbiol., 160, 134, 10.1016/j.resmic.2008.11.002

Horosheva, 2014, Efficacy of Bacillus probiotics in prevention of antibiotic-associated diarrhoea: a randomized, double-blind, placebo-controlled clinical trial., JMM Case Rep., 1, 1, 10.1099/jmmcr.0.004036

Hosoi, 2003, “Natto – a food made by fermenting cooked soybeans with Bacillus subtilis (natto),” in, Handbook of Fermented Functional Foods, 227

Hoyles, 2012, Recognition of greater diversity of Bacillus species and related bacteria in human faeces., Res. Microbiol., 163, 3, 10.1016/j.resmic.2011.10.004

Hyronimus, 2000, Acid and bile tolerance of spore-forming lactic acid bacteria., Int. J. Food Microbiol., 61, 193, 10.1016/S0168-1605(00)00366-4

Inatsu, 2006, Characterization of Bacillus subtilis strains in Thuanao, a traditional fermented soybean food in northern Thailand., Lett. Appl. Microbiol., 43, 237, 10.1111/j.1472-765X.2006.01966.x

Jager, 2016, Probiotic Bacillus coagulans GBI-30, 6086 reduces exercise-induced muscle damage and increases recovery., Peer J., 4, 10.7717/peerj.2276

Jeong, 2016, Draft genome sequences of four plant probiotic Bacillus strains., Genome Announc., 4, e00358, 10.1128/genomeA.00358-16

Joseph, 2013, Bacteriocin from Bacillus subtilis as a novel drug against diabetic foot ulcer bacterial pathogens., Asian Pac. J. Trop. Biomed., 3, 942, 10.1016/S2221-1691(13)60183-5

Kalliomäki, 2001, Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial., Lancet, 357, 1076, 10.1016/S0140-6736(00)04259-8

Karu, 2016, Survival of Lactobacillus rhamnosus GG during simulated gastrointestinal conditions depending on food matrix., J. Food Res., 5, 57, 10.5539/jfr.v5n5p56

Khochamit, 2015, Antibacterial activity and genotypic–phenotypic characteristics of bacteriocin-producing Bacillus subtilis KKU213: potential as a probiotic strain., Microbiol. Res., 170, 36, 10.1016/j.micres.2014.09.004

Khodadad, 2013, Probiotics for the treatment of pediatric Helicobacter pylori infection: a randomized double blind clinical trial., Iran J. Pediatr., 23, 79

Kniehl, 2003, Pseudo-outbreak of toxigenic Bacillus cereus isolated from stools of three patients with diarrhoea after oral administration of a probiotic medication., J. Hosp. Infect., 55, 33, 10.1016/S0195-6701(03)00133-6

Kolsto, 2009, What sets Bacillus anthracis apart from other Bacillus species., Annu. Rev. Microbiol., 63, 451, 10.1146/annurev.micro.091208.073255

Kosak, 1998, Effect of Bacillus subtilis spore administration on activation of macrophages and natural killer cells in mice., Vet. Microbiol., 60, 215, 10.1016/S0378-1135(97)00102-8

Kotb, 2015, Purification and partial characterization of serine fibrinolytic enzyme from Bacillus megaterium KSK-07 isolated from kishk, a traditional Egyptian fermented food., Appl. Biochem. Microbiol., 51, 34, 10.1134/S000368381501007X

Kramer, 1989, “Bacillus cereus and other Bacillus species,” in, Foodborne Bacterial Pathogens, 21

Krawczyk, 2016, Genome sequences of 12 spore-forming Bacillus species, comprising Bacillus coagulans, Bacillus licheniformis, Bacillus amyloliquefaciens, Bacillus sporothermodurans, and Bacillus vallismortis, isolated from foods., Genome Announc., 4, 103, 10.1128/genomeA.00103-16

Lee, 2012, The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells., Food Chem., 131, 1347, 10.1016/j.foodchem.2011.09.133

Lee, 2016, Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet., Br. J. Nutr., 116, 603, 10.1017/S0007114516002270

Lefevre, 2015, Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study., Immun. Ageing, 12, 10.1186/s12979-015-0051-y

Li, 2015, Effects of a probiotic mixture (Bacillus subtilis YB-1 and Bacillus cereus YB-2) on disease resistance and non-specific immunity of sea cucumber, Apostichopus japonicus (Selenka)., Aquac. Res., 46, 3008, 10.1111/are.12453

London, 2014, Exopolysaccharide-producing probiotic Lactobacilli reduce serum cholesterol and modify enteric microbiota in ApoE-deficient mice., J. Nutr., 144, 1956, 10.3945/jn.114.191627

Lopetuso, 2016, Bacillus clausii and gut homeostasis: state of the art and future perspectives, Expert Rev. Gastroenterol. Hepatol., 10, 943, 10.1080/17474124

Majeed, 2016, Evaluation of the stability of Bacillus coagulans MTCC 5856 during processing and storage of functional foods., Int. J. Food Sci. Technol., 51, 894, 10.1111/ijfs.13044

Mallappa, 2012, Management of metabolic syndrome through probiotic and prebiotic interventions., Indian J. Endocrinol. Metab., 16, 20, 10.4103/2230-8210.91178

Maneerat, 2014, Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes., J. Nutr. Sci., 44, 1, 10.1017/jns.2013.31

Manhar, 2016, Cellulolytic potential of probiotic Bacillus Subtilis AMS6 isolated from traditional fermented soybean (Churpi): An in-vitro study with regards to application as an animal feed additive., Microbiol. Res., 186, 62, 10.1016/j.micres.2016.03.004

Mohammed, 2014, Development of a two-step cultivation strategy for the production of vitamin B12 by Bacillus megaterium., Microb. Cell Fact., 13, 10.1186/s12934-014-0102-7

Mullany, 2004, “Mechanisms of gene transfer and the spread of antibiotic resistance in spore forming organisms in the GI tract,” in, Bacterial Spore Formers: Probiotics and Emerging Applications, 113

Muscettola, 1992, Effects of Bacillus subtilis spores on interferon production., Pharmacol. Res., 26, 176, 10.1016/1043-6618(92)90652-R

Muscettola, 1991, Plasma interferon-like activity in rabbits after oral administration of Bacillus subtilis spores., J. Chemother., 3, 130

Nagal, 1996, Study on surfactin, a cyclic depsipeptide II synthesis of surfactin B2 produced by Bacillus natto KMD 2311., Chem. Phar. Bull. (Tokyo)., 44, 5, 10.1248/cpb.44.5

Nyangale, 2015, Bacillus coagulans GBI-30 6086 modulates Faecalibacterium prausnitziiin older men and women., J. Nutr., 145, 1446, 10.3945/jn.114.199802

Nyangale, 2014, Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086., Anaerobe, 30, 75, 10.1016/j.anaerobe.2014.09.002

Ouattara, 2017, Regulation of the synthesis of pulp degrading enzymes in Bacillus isolated from cocoa fermentation., Food Microbiol., 63, 255, 10.1016/j.fm.2016.12.004

Ozawa, 1979, Bacillus natto and Streptococcus faecalis on growth of Candida albicans, Microbiol. Immunol., 23, 1147, 10.1111/j.1348-0421.1979.tb00547.x

Panwar, 2014, Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha-and beta-glucosidases suggesting anti-diabetic potential., Eur. J. Nutr., 53, 1465, 10.1007/s00394-013-0649-9

Panwar, 2016, Lactobacilli possess inhibitory activity against dipeptidyl peptidase-4 (DPP-4)., Ann. Microbiol., 66, 505, 10.1007/s13213-015-1129-7

Pinchuk, 2001, In vitro Anti-Helicobacter pylori Activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics., Antimicrob. Agents Chemother., 45, 3156, 10.1128/AAC.45.11.3156-3161.2001

Prokesova, 1994, Effect of Bacillus firmus and other sporulating aerobic microorganisms on in vitro stimulation of human lymphocytes. A comparative study., Folia Microbiol., 39, 501, 10.1007/BF02814071

Ramarao, 2006, Adhesion and cytotoxicity of Bacillus cereus and Bacillus thuringiensis to epithelial cells are FlhA and PlcR dependent, respectively., Microbes Infect., 8, 1483, 10.1016/j.micinf.2006.01.005

Rani, 2016, Purification of antilisterial aeptide (Subtilosin A) from novel Bacillus tequilensis FR9 and demonstrate their pathogen invasion protection ability using human carcinoma cell line., Front. Microbiol., 7, 10.3389/fmicb.2016.01910

Ranji, 2015, Associations of probiotics with vitamin D and leptin receptors and their effects on colon cancer., Asian Pac. J. Cancer Prev., 16, 3621, 10.7314/APJCP.2015

Rao, 2015, Probiotic potential of Lactobacillus strains isolated from sorghum-based traditional fermented food., Probiotics Antimicrob. Proteins, 7, 146, 10.1007/s12602-015-9186-6

Redman, 2014, The efficacy and safety of probiotics in people with cancer: a systematic review., Ann. Oncol., 25, 1919, 10.1093/annonc/mdu106

Rey, 2004, Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species., Genome Biol., 5, 10.1186/gb-2004-5-10-r77

Ripert, 2016, Secreted compounds of the probiotic Bacillus clausii strain O/C inhibit the cytotoxic effects induced by Clostridium difficile and Bacillus cereus toxins., Antimicrob. Agents Chemother., 60, 3445, 10.1128/AAC.02815-15

Rowan, 2001, Putative virulence factor expression by clinical and food isolates of Bacillus spp. after growth in reconstituted infant milk formulae., Appl. Environ. Microbiol., 67, 3873, 10.1128/AEM.67.9.3873-3881.2001

Sah, 2014, Effect of probiotics on antioxidant and antimutagenic activities of crude peptide extract from yogurt., Food Chem., 156, 264, 10.1016/j.foodchem.2014.01.105

Sanchez, 2009, Identification of surface proteins involved in the adhesion of a probiotic Bacillus cereus strain to mucin and fibronectin., Microbiology, 155, 1708, 10.1099/mic.0.025288-0

1999, Opinion of of the Scientific Steering Committee on Antimicrobial Resistance. European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition.

2002, Opinion of the Scientific Committee on Animal Nutrition (SCAN) on the use of Bacillus licheniformis NCTC 13123 in Feeding Stuffs for Pigs (product AlCare). European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition.

2003, Opinion of the Scientific Committee on Animal Nutrition, on the Criteria for Assessing the Safety of Microorganisms Resistant to Antibiotics of Human Clinical and Veterinary Importance. European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition.

Schierack, 2007, Bacillus cereus var. toyoi enhanced systemic immune response in piglets, Vet. Immunol. Immunopathol., 118, 1, 10.1016/j.vetimm.2007.03.006

Scott, 2015, Manipulating the gut microbiota to maintain health and treat disease., Microb. Ecol. Health Dis., 26, 10.3402/mehd.v26.25877

Senesi, 2001, Molecular characterization and identification of Bacillus clausii strains marketed for use in oral bacteriotherapy., Appl. Environ. Microbiol., 67, 834, 10.1128/AEM.67.2.834-839.200

Shida, 2013, Probiotics as efficient immuno potentiators: translational role in cancer prevention., Indian J. Med. Res., 138, 808

Shimizu, 2013, Probiotic/synbiotic therapy for treating critically ill patients from a gut microbiota perspective., Dig. Dis. Sci., 58, 23, 10.1007/s10620-012-2334-x

Shobharani, 2015, Diversity in the antibacterial potential of probiotic cultures Bacillus licheniformis MCC2514 and Bacillus licheniformis MCC2512., Res. Microbiol., 166, 546, 10.1016/j.resmic.2015.06.003

Sorokulova, 2008, The safety of two Bacillus probiotic strains for human use., Dig. Dis. Sci., 53, 954, 10.1007/s10620-007-9959-1

Stein, 2005, Bacillus subtilis antibiotics: structures, syntheses and specific functions., Mol. Microbiol., 56, 845, 10.1111/j.1365-2958.2005.04587.x

Sudha, 2012, Efficacy of Bacillus coagulans strain Unique IS-2 in the treatment of patients with acute diarrhea., Int. J. Probiotics Prebiotics, 7, 33

Takano, 2016, The regulatory mechanism underlying light-inducible production of carotenoids in non phototrophic bacteria., Biosci. Biotechnol. Biochem., 80, 1264, 10.1080/09168451.2016.1156478

Tam, 2006, The intestinal life cycle of Bacillus subtilis and close relatives., J. Bacteriol., 188, 2692, 10.1128/JB.188.7.2692-2700.2006

Tamang, 2016, Review: diversity of microorganisms in global fermented foods and beverages., Front. Microbiol., 7, 10.3389/fmicb.2016.00377

Tanaka, 2014, A second-generation Bacillus cell factory for rare inositol production., Bioengineered, 5, 331, 10.4161/bioe.29897

Taras, 2005, Response of performance characteristics and fecal consistency to long-lasting dietary supplementation with the probiotic strain Bacillus cereus var. toyoi to sows and piglets., Arch. Anim. Nutr., 59, 405, 10.1080/17450390500353168

Terlabie, 2006, The comparative ability of four isolates of Bacillus subtilis to ferment soybeans into dawadawa., Int. J. Food Microbiol., 106, 145, 10.1016/j.ijfoodmicro.2005.05.021

Tewari, 2015, Bacillus clausii for prevention of late-onset sepsis in preterm infants: a randomized controlled trial, J. Trop. Pediatr., 61, 377, 10.1093/tropej/fmv050

Thakur, 2016, Probiotics: selection criteria, safety and role in health and disease., J. Innov. Biol., 3, 259

Trocino, 2005, Effect of diet supplementation with Toyocerin® (Bacillus cereus var. toyoi) on performance and health of growing rabbits., World Rabbit Sci., 13, 17

Urgesi, 2014, A randomized double-blind placebo-controlled clinical trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox®) in patients with irritable bowel syndrome., Eur. Rev. Med. Pharmacol. Sci., 18, 1344

Von Mollendorff, 2016, “Boza, a traditional cereal-based fermented beverage: a rich source of probiotics and bacteriocin-producing lactic acid bacteria,” in, Functional Properties of Traditional Foods, 157, 10.1007/978-1-4899-7662-8_12

Wang, 2015, Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice., ISME J., 9, 1, 10.1038/ismej.2014.99

Weese, 2011, Assessment of commercial probiotic bacterial contents and label accuracy., Can. Vet. J., 52

Xu, 2003, Phylogenetic relationships between Bacillus species and related genera inferred from comparison of 3′ end 16S rDNA and 5′ end 16S–23S ITS nucleotide sequences., Int. J. Syst. Evol. Microbiol., 53, 695, 10.1099/ijs.0.02346-0

Yang, 2014, Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer’s type dementia., Eur. J. Nutr., 54, 77, 10.1007/s00394-014-0687-y

Yang, 2014, Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial., AIDS Res. Hum. Retroviruses, 30, 988, 10.1089/aid.2014.0181

Zhang, 2016, Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice., Exp. Ther. Med., 12, 2554, 10.3892/etm.2016.3686

Zhao, 2016, In vitro inhibitory activity of probiotic products against oral Candida species, J. Appl. Microbiol., 121, 254, 10.1111/jam.13138

Zheng, 2016, Antioxidant and DNA damage arotecting Activity of exopolysaccharides from the endophytic bacterium Bacillus Cereus SZ1., Molecules, 21, 10.3390/molecules21020174

Zhu, 2016, Probiotic Bacillus cereus strains, a potential risk for public health in China., Front. Microbiol., 7, 10.3389/fmicb.2016.00718

Zouari, 2015, Assessment of the antidiabetic and antilipidemic properties of Bacillus subtilis SPB1 biosurfactant in alloxan-induced diabetic rats., Pept. Sci., 104, 764, 10.1002/bip.22705