BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

Asselin-Labat, 2010, Control of mammary stem cell function by steroid hormone signalling, Nature, 465, 798, 10.1038/nature09027

Barbera, 2009, Cellular mechanisms of Barrett's esophagus development, Surg. Oncol. Clin. N. Am., 18, 393, 10.1016/j.soc.2009.03.001

Booth, 2006, Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands, Breast Cancer Res., 8, R49, 10.1186/bcr1538

Cicalese, 2009, The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells, Cell, 138, 1083, 10.1016/j.cell.2009.06.048

Dontu, 2003, Stem cells in normal breast development and breast cancer, Cell Prolif., 36, 59, 10.1046/j.1365-2184.36.s.1.6.x

Foulkes, 2004, BRCA1 functions as a breast stem cell regulator, J. Med. Genet., 41, 1, 10.1136/jmg.2003.013805

Geyer, 2010, Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas, J. Pathol., 220, 562, 10.1002/path.2675

Gorski, 2010, BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer, Breast Cancer Res. Treat., 122, 721, 10.1007/s10549-009-0565-0

Gusterson, 2009, Do ‘basal-like’ breast cancers really exist?, Nat. Rev. Cancer, 9, 128, 10.1038/nrc2571

Gusterson, 2005, Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer, Breast Cancer Res., 7, 143, 10.1186/bcr1041

Hosey, 2007, Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer, J. Natl. Cancer Inst., 99, 1683, 10.1093/jnci/djm207

Hu, 2006, The molecular portraits of breast tumors are conserved across microarray platforms, BMC Genomics, 7, 96, 10.1186/1471-2164-7-96

Irizarry, 2003, Exploration, normalization, and summaries of high density oligonucleotide array probe level data, Biostatistics, 4, 249, 10.1093/biostatistics/4.2.249

Jonkers, 2001, Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer, Nat. Genet., 29, 418, 10.1038/ng747

Kendrick, 2008, Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate, BMC Genomics, 9, 591, 10.1186/1471-2164-9-591

Lakhani, 2005, Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype, Clin. Cancer Res., 11, 5175, 10.1158/1078-0432.CCR-04-2424

Lim, 2009, Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers, Nat. Med., 15, 907, 10.1038/nm.2000

Liu, 2007, Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer, Proc. Natl. Acad. Sci. USA, 104, 12111, 10.1073/pnas.0702969104

Liu, 2008, BRCA1 regulates human mammary stem/progenitor cell fate, Proc. Natl. Acad. Sci. USA, 105, 1680, 10.1073/pnas.0711613105

Mallepell, 2006, Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland, Proc. Natl. Acad. Sci. USA, 103, 2196, 10.1073/pnas.0510974103

Marusyk, 2010, Tumor heterogeneity: Causes and consequences, Biochim. Biophys. Acta, 1805, 105

McCarthy, 2007, A mouse model of basal-like breast carcinoma with metaplastic elements, J. Pathol., 211, 389, 10.1002/path.2124

Melchor, 2008, An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes, Carcinogenesis, 29, 1475, 10.1093/carcin/bgn157

Mesquita, 2006, Metaplasia—A transdifferentiation process that facilitates cancer development: The model of gastric intestinal metaplasia, Crit. Rev. Oncog., 12, 3, 10.1615/CritRevOncog.v12.i1-2.20

Natrajan, 2010, An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers, Breast Cancer Res. Treat., 121, 575, 10.1007/s10549-009-0501-3

Naylor, 2005, Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation, J. Cell Biol., 171, 717, 10.1083/jcb.200503144

Nielsen, 2004, Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma, Clin. Cancer Res., 10, 5367, 10.1158/1078-0432.CCR-04-0220

Oakes, 2008, The Ets transcription factor Elf5 specifies mammary alveolar cell fate, Genes Dev., 22, 581, 10.1101/gad.1614608

Palacios, 2005, Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers, Breast Cancer Res. Treat., 90, 5, 10.1007/s10549-004-1536-0

Parker, 2009, Supervised risk predictor of breast cancer based on intrinsic subtypes, J. Clin. Oncol., 27, 1160, 10.1200/JCO.2008.18.1370

Pece, 2010, Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content, Cell, 140, 62, 10.1016/j.cell.2009.12.007

Polyak, 2009, Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits, Nat. Rev. Cancer, 9, 265, 10.1038/nrc2620

Rakha, 2008, Basal-like breast cancer: A critical review, J. Clin. Oncol., 26, 2568, 10.1200/JCO.2007.13.1748

Rebbeck, 2002, Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations, N. Engl. J. Med., 346, 1616, 10.1056/NEJMoa012158

Shackleton, 2006, Generation of a functional mammary gland from a single stem cell, Nature, 439, 84, 10.1038/nature04372

Sleeman, 2006, CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells, Breast Cancer Res., 8, R7, 10.1186/bcr1371

Sleeman, 2007, Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland, J. Cell Biol., 176, 19, 10.1083/jcb.200604065

Smalley, 2003, Stem cells and breast cancer: A field in transit, Nat. Rev. Cancer, 3, 832, 10.1038/nrc1212

Smart, 2008, Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia, Breast Cancer Res. Treat., 112, 237, 10.1007/s10549-007-9859-2

Sorlie, 2003, Repeated observation of breast tumor subtypes in independent gene expression data sets, Proc. Natl. Acad. Sci. USA, 100, 8418, 10.1073/pnas.0932692100

Stingl, 2006, Purification and unique properties of mammary epithelial stem cells, Nature, 439, 993, 10.1038/nature04496

Subramanian, 2005, Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, 102, 15545, 10.1073/pnas.0506580102

Taddei, 2008, Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells, Nat. Cell Biol., 10, 716, 10.1038/ncb1734

Tibshirani, 2002, Diagnosis of multiple cancer types by shrunken centroids of gene expression, Proc. Natl. Acad. Sci. USA, 99, 6567, 10.1073/pnas.082099299

van de Vijver, 2002, A gene-expression signature as a predictor of survival in breast cancer, N. Engl. J. Med., 347, 1999, 10.1056/NEJMoa021967

Vassilopoulos, 2008, Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells, Int. J. Biol. Sci., 4, 133, 10.7150/ijbs.4.133

Weigelt, 2010, Breast cancer molecular profiling with single sample predictors: A retrospective analysis, Lancet Oncol., 11, 339, 10.1016/S1470-2045(10)70008-5