BOLD and Perfusion Response to Finger-Thumb Apposition after Acetazolamide Administration: Differential Relationship to Global Perfusion

Journal of Cerebral Blood Flow and Metabolism - Tập 23 Số 7 - Trang 829-837 - 2003
Gregory G. Brown1,2, Lisa T. Eyler Zorrilla1,2, Bassem Georgy3, Sandra S. Kindermann1,4, Eric C. Wong1,3, Richard B. Buxton3
1Department of Psychiatry, University of California San Diego, San Diego, California
2VA San Diego Healthcare System, San Diego, California
3Department of Radiology, University of California, San Diego, San Diego, California
4VA Long Beach Healthcare System, Long Beach, California, U.S.A.

Tóm tắt

The authors studied the effects of altering global cerebral blood flow on both blood oxygen level–dependent (BOLD) response and perfusion response to finger-thumb apposition. A PICORE/QUIPSS II protocol was used to collect interleaved BOLD-weighted and perfusion-weighted images on eight finger-thumb apposition trials. Subjects were studied on a drug-free day and on a day when acetazolamide was administered between the second and third trials. After acetazolamide administration, resting cortical perfusion increased an average of 20% from preadministration levels, whereas the BOLD response to finger-thumb apposition decreased by an average of 35% in the S1M1 hand area. Contrary to predictions from the exhausted cerebrovascular reserve hypothesis and the oxygen limitation model, an effect of acetazolamide on cerebral blood flow response in the S1M1 hand area was not observed. Across the acetazolamide trials, BOLD response was inversely correlated with resting cortical perfusion for individual subject data. These results suggest that resting perfusion affects the magnitude of the BOLD response and is thus an important confounding factor in fMRI studies, and that the physiologic systems that increase cerebral blood flow in response to acetazolamide administration and systems that increase cerebral blood flow in response to altered neural activity appear to have additive effects.

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Journal of Cerebral Blood Flow and Metabolism

Tập 23 Số 7

829-837

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