BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
Peipei Xue1, Fanfan Zeng1, Qiuhong Duan1, Juanjuan Xiao1, Lin Liu1, Ping Yuan1, Linni Fan2, Huimin Sun3, Olesya S. Malyarenko1,4, Hui Lu1, Ruijuan Xiu1, Shaoqing Liu5, Chen Shao3, Jianmin Zhang1, Wei Yan2, Zhe Wang2, Jianyong Zheng5, Feng Zhu1
1Department of Biochemistry and Molecular Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
2Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China
3Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China
4G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Laboratory of Enzyme Chemistry, Vladivostok, Russia
5Department of State Key Laboratory of Cancer Biology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China