B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains

Aletaha, 2010, 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative, Ann Rheum Dis, 69, 1580, 10.1136/ard.2010.138461

Dwivedi, 2012, Felty’s syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps, Arthritis Rheum, 64, 982, 10.1002/art.33432

Dwivedi, 2014, Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity, FASEB J, 28, 2840, 10.1096/fj.13-247254

Vossenaar, 2003, PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease, Bioessays, 25, 1106, 10.1002/bies.10357

Neeli, 2008, Histone deimination as a response to inflammatory stimuli in neutrophils, J Immunol, 180, 1895, 10.4049/jimmunol.180.3.1895

Chang, 2015, The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis, Arthritis Rheumatol, 67, 2323, 10.1002/art.39215

Muller, 2015, Citrullinated autoantigens: from diagnostic markers to pathogenetic mechanisms, Clin Rev Allergy Immunol, 49, 232, 10.1007/s12016-014-8459-2

Dwivedi, 2014, Citrullination of autoantigens implicates NETosis in the induction of autoimmunity, Ann Rheum Dis, 73, 483, 10.1136/annrheumdis-2013-203844

Khandpur, 2013, NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis, Sci Transl Med, 5, 178ra40, 10.1126/scitranslmed.3005580

Spengler, 2015, Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial fluid, Arthritis Rheumatol, 67, 3135, 10.1002/art.39313

Darrah, 2012, Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis, Ann Rheum Dis, 71, 92, 10.1136/ard.2011.151712

Romero, 2013, Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis, Sci Transl Med, 5, 209ra150, 10.1126/scitranslmed.3006869

Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385

Brinkmann, 2007, Beneficial suicide: why neutrophils die to make NETs, Nat Rev Microbiol, 5, 577, 10.1038/nrmicro1710

Pratesi, 2015, Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses, Lupus, 24, 433, 10.1177/0961203314560005

Lande, 2011, Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus, Sci Transl Med, 3, 73ra19, 10.1126/scitranslmed.3001180

Garcia-Romo, 2011, Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus, Sci Transl Med, 3, 73ra20, 10.1126/scitranslmed.3001201

van Bavel, 2009, Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies, Mol Immunol, 47, 511, 10.1016/j.molimm.2009.08.009

Liu, 2012, Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies, Arthritis Res Ther, 14, R25, 10.1186/ar3707

Seri, 2015, Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model, Sci Rep, 5, 13041, 10.1038/srep13041

Shelef, 2014, Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha-induced inflammatory arthritis, Arthritis Rheumatol, 66, 1482, 10.1002/art.38393

Konig, 2014, Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of “true ACPAs” in an experimental model of arthritis: comment on the article by Shelef et al, Arthritis Rheumatol, 66, 2642, 10.1002/art.38719

Cantaert, 2013, Presence and role of anti-citrullinated protein antibodies in experimental arthritis models, Arthritis Rheum, 65, 939, 10.1002/art.37839

Pratesi, 2014, Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps, Ann Rheum Dis, 73, 1414, 10.1136/annrheumdis-2012-202765

Kearney, 2005, Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis, Biochemistry, 44, 10570, 10.1021/bi050292m

Moens, 1995, In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones, Proc Natl Acad Sci U S A, 92, 12393, 10.1073/pnas.92.26.12393

Kalaaji, 2006, Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis, Arthritis Rheum, 54, 914, 10.1002/art.21622

Andreassen, 1999, T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: a molecular basis for anti-DNA antibody production, Eur J Immunol, 29, 2715, 10.1002/(SICI)1521-4141(199909)29:092715::AID-IMMU27153.3.CO;2-R

Bredholt, 2001, Differences in the reactivity of CD4+ T-cell lines generated against free versus nucleosome-bound SV40 large T antigen, Scand J Immunol, 53, 372, 10.1046/j.1365-3083.2001.00873.x

Mehrad, 2006, The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections, J Immunol, 176, 3233, 10.4049/jimmunol.176.5.3233

Monestier, 1993, Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice, Mol Immunol, 30, 1069, 10.1016/0161-5890(93)90153-3

Lambert, 1968, Pathogenesis of the glomerulonephritis of NZB/W mice, J Exp Med, 127, 507, 10.1084/jem.127.3.507

Ireland, 2011, Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells, J Exp Med, 208, 2625, 10.1084/jem.20110640

Dwivedi, 2012, Felty’s syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps, Arthritis Rheum, 64, 982, 10.1002/art.33432

Uhlen, 2010, Towards a knowledge-based human protein atlas, Nat Biotechnol, 28, 1248, 10.1038/nbt1210-1248