Axonal transport failure in neurodegenerative disorders: the case of Huntington’s disease

Pathologie Biologie - Tập 53 Số 4 - Trang 189-192 - 2005
Bénédicte C. Charrin1, Frédéric Saudou1, Sandrine Humbert1
1UMR 146 CNRS, Institut Curie, Bldg. 110, Centre Universitaire, 91405 Orsay Cedex, France.

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Tài liệu tham khảo

Martin, 1986, Huntington’s disease. Pathogenesis and management, N Engl J Med, 315, 1267, 10.1056/NEJM198611133152006

Rangone, 2004, Huntington’s disease: how does huntingtin, an anti-apoptotic protein, become toxic?, Pathol Biol (Paris), 52, 338, 10.1016/j.patbio.2003.06.004

Zeitlin, 1995, Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington’s disease gene homologue, Nat Genet, 11, 155, 10.1038/ng1095-155

Dragatsis, 2000, Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice, Nat Genet, 26, 300, 10.1038/81593

Rigamonti, 2001, Huntingtin’s neuroprotective activity occurs via inhibition of procaspase-9 processing, J Biol Chem, 276, 14545, 10.1074/jbc.C100044200

Gutekunst, 1995, Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies, Proc Natl Acad Sci USA, 92, 8710, 10.1073/pnas.92.19.8710

Hoffner, 2002, Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington’s disease, J Cell Sci, 115, 941, 10.1242/jcs.115.5.941

Li, 1995, A huntingtin-associated protein enriched in brain with implications for pathology, Nature, 378, 398, 10.1038/378398a0

Kalchman, 1997, HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain, Nat Genet, 16, 44, 10.1038/ng0597-44

Wanker, 1997, HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system, Hum Mol Genet, 6, 487, 10.1093/hmg/6.3.487

Singaraja, 2002, HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis, Hum Mol Genet, 11, 2815, 10.1093/hmg/11.23.2815

Modregger, 2002, PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington’s disease brains, Hum Mol Genet, 11, 2547, 10.1093/hmg/11.21.2547

Kuruvilla, 2004, A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling, Cell, 118, 243, 10.1016/j.cell.2004.06.021

Heerssen, 2004, Dynein motors transport activated Trks to promote survival of target-dependent neurons, Nat Neurosci, 7, 596, 10.1038/nn1242

Vallee, 2003, Molecular motors: a magnificent machine, Nature, 421, 701, 10.1038/421701a

Vale, 2003, The molecular toolbox for intracellular transport, Cell, 112, 467, 10.1016/S0092-8674(03)00111-9

Hirokawa, 2004, Kinesin superfamily proteins and their various functions and dynamics, Exp Cell Res, 301, 50, 10.1016/j.yexcr.2004.08.010

Hirokawa, 1998, Kinesin and dynein superfamily proteins and the mechanism of organelle transport, Science, 279, 519, 10.1126/science.279.5350.519

Gunawardena, 2003, Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila, Neuron, 40, 25, 10.1016/S0896-6273(03)00594-4

Gauthier, 2004, Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular trannsport along microtubules, Cell, 118, 127, 10.1016/j.cell.2004.06.018

Zuccato, 2001, Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease, Science, 293, 493, 10.1126/science.1059581

DiFiglia, 1997, Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990

Saudou, 1998, Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions, Cell, 95, 55, 10.1016/S0092-8674(00)81782-1

Ross, 2002, Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington’s disease and related disorders, Neuron, 35, 819, 10.1016/S0896-6273(02)00872-3

Li, 2000, Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity, Nat Genet, 25, 385, 10.1038/78054

Szebenyi, 2003, Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport, Neuron, 40, 41, 10.1016/S0896-6273(03)00569-5

Trushina, 2004, Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro, Mol Cell Biol, 24, 8195, 10.1128/MCB.24.18.8195-8209.2004

Lee, 2004, Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington’s disease, Proc Natl Acad Sci USA, 101, 3224, 10.1073/pnas.0400243101

Piccioni, 2002, Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes, FASEB J, 16, 1418, 10.1096/fj.01-1035fje

Gunawardena, 2001, Disruption of axonal transport and neuronal viability by amiloid precursor mutations in Drosophila, Neuron, 32, 389, 10.1016/S0896-6273(01)00496-2

Stamer, 2002, Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxydative stress, J Cell Biol, 156, 1051, 10.1083/jcb.200108057

Zhao, 2001, Charcot–Marie–Tooth disease type 2A caused by mutation in a microtubule motor KIF1B beta, Cell, 105, 587, 10.1016/S0092-8674(01)00363-4

Reid, 2002, A kinesin heavy chain (KIF5A) mutation in hereditary spasic paraplegia (SPG10), Am J Hum Genet, 71, 1189, 10.1086/344210

Puls, 2003, Mutant dynactin in motor neuron disease, Nat Genet, 33, 455, 10.1038/ng1123

Hafezparast, 2003, Mutations in dynein link motor neuron degeneration to defects in retrograde transport, Science, 300, 808, 10.1126/science.1083129

LaMonte, 2002, Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration, Neuron, 34, 715, 10.1016/S0896-6273(02)00696-7