Axonal Regeneration, but Not Myelination, Is Partially Dependent on Local Cholesterol Reutilization in Regenerating Nerve

Journal of Neuropathology and Experimental Neurology - Tập 59 Số 11 - Trang 1002-1010 - 2000
Jeffry F. Goodrum1,2, Justin C. Brown3, Kenneth A. Fowler2, Thomas W. Bouldin1
1Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
2Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
3School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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Tài liệu tham khảo

10.1073/pnas.83.4.1125

10.1073/pnas.83.4.1130

10.1016/S0079-6123(08)61822-1

10.1126/science.3283935

10.1111/j.1471-4159.1990.tb01225.x

10.1111/j.1471-4159.1991.tb03469.x

Goodrum, 1994, Fate of myelin lipids during degeneration and regeneration of peripheral nerve: An autoradiographic study, J Neuroscience, 14, 357, 10.1523/JNEUROSCI.14-01-00357.1994

10.1111/j.1471-4159.1993.tb03322.x

Goodrum, 1995, Fatty acids from degenerating myelin lipids are conserved and reutilized for myelin synthesis during regeneration in peripheral nerve, J Neurochem, 65, 1752, 10.1046/j.1471-4159.1995.65041752.x

10.1097/00005072-199609000-00001

Handlemann, 1992, Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro, J Lipid Res, 3, 1677, 10.1016/S0022-2275(20)41390-2

10.1126/science.8171342

Fagan, 1996, Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein (LRP), J Cell Biol, 271, 30121

10.1074/jbc.272.49.30766

10.1074/jbc.275.26.19883

10.1002/(SICI)1097-4547(19970801)49:3<389::AID-JNR14>3.0.CO;2-V

10.1159/000112179

Underwood, 1996, Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport, J Lipid Res, 37, 1556, 10.1016/S0022-2275(20)39138-0

10.1126/science.277.5323.232

Rath, 1995, Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect, J Neurosci, 15, 7226, 10.1523/JNEUROSCI.15-11-07226.1995

Clarke CF Edwards PA Fogelman AM . Cellular regulation of cholesterol metabolism. In: Gotto AM , ed. Plasma lipoproteins. Amsterdam: Elsevier, 1987:261–76

Goodrum, 1995, nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice, J Neurochem, 64, 408, 10.1046/j.1471-4159.1995.64010408.x

10.1074/jbc.274.14.9627

Xie, 1999, Cholesterol balance and metabolism in mice with loss of function on Nieman-Pick C protein, Am J Physiol, 276, E336

10.1111/j.1471-4159.1983.tb11318.x

Sunderland S . Nerve injuries and their repair: A critical appraisal. Edinburgh: Churchill Livingstone, 1991

10.1016/S0306-4522(97)00661-1

Masliah E Mallory M Ge N Alford M Veinbergs I Roses AD . Abnormal synaptic regeneration in hAPP695 transgenic and apoE knockout mice. In: Iqbal K Mortimer JA Winblad B Wisniewski HM , eds. Research advances in Alzheimer's disease and related disorders, New York: Wiley, 1995:405–14

10.1006/exnr.1998.6818

10.1016/0166-2236(94)90156-2

10.1097/00041433-199906000-00003

10.1007/s11745-999-0357-9