Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice

Alexandre-Silva GM, 2018, The hygiene hypothesis at a glance: early exposures, immune mechanismand novel therapies, Acta Trop., 188, 16, 10.1016/j.actatropica.2018.08.032 Okada, 2010, The ’hygiene hypothesis’ for autoimmune and allergic diseases: an update, Clin. Exp. Immunol., 160, 1, 10.1111/j.1365-2249.2010.04139.x Rook, 2005, Old friends for breakfast, Clin. Exp. Allergy, 35, 841, 10.1111/j.1365-2222.2005.02112.x Scrivener, 2001, Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study, Lancet, 358, 1493, 10.1016/S0140-6736(01)06579-5 Yazdanbakhsh, 2001, Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease, Trends Immunol., 22, 372, 10.1016/S1471-4906(01)01958-5 van den Biggelaar, 2000, Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10, Lancet, 356, 1723, 10.1016/S0140-6736(00)03206-2 Smallwood, 2017, Helminth immunomodulation in autoimmune disease, Front. Immunol., 8, 453, 10.3389/fimmu.2017.00453 Hubner, 2009, Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells, Immunology, 127, 512, 10.1111/j.1365-2567.2008.02958.x Hubner, 2012, Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta, J. Immunol., 188, 559, 10.4049/jimmunol.1100335 Shepherd, 2015, Identifying the immunomodulatory components of helminths, Parasite Immunol., 37, 293, 10.1111/pim.12192 Sobotkova, 2019, Helminth therapy - from the parasite perspective, Trends Parasitol., 35, 501, 10.1016/j.pt.2019.04.009 Stiernagle, 2006, Maintenance of C. elegans, February, 11 Nass, 2007, The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters, Curr Protoc Toxicol, 31, 1.9.1, 10.1002/0471140856.tx0109s31 Szewczyk, 2003, Chemically defined medium and Caenorhabditis elegans, BMC Biotechnol., 3, 19, 10.1186/1472-6750-3-19 Samuel, 2014, Culturing Caenorhabditis elegans in axenic liquid media and creation of transgenic worms by microparticle bombardment, JoVE, 90 Cooke, 1999, Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice, Parasite Immunol., 21, 169, 10.1046/j.1365-3024.1999.00213.x Saunders, 2007, Inhibition of autoimmune type 1 diabetes by gastrointestinal helminth infection, Infect. Immun., 75, 397, 10.1128/IAI.00664-06 La Flamme, 2003, Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis, Infect. Immun., 71, 4996, 10.1128/IAI.71.9.4996-5004.2003 Summers, 2005, Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial, Gastroenterology, 128, 825, 10.1053/j.gastro.2005.01.005 Mishra, 2013, Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response, Mucosal Immunol., 6, 297, 10.1038/mi.2012.71 Tang, 2019, Helminths protect against type 1 diabetes: effects and mechanisms, Parasitol. Res., 118, 1087, 10.1007/s00436-019-06247-4 Quinn, 2019, Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis, Eur. J. Immunol., 49, 1291, 10.1002/eji.201948147 Maizels, 2020, Regulation of immunity and allergy by helminth parasites, Allergy, 75, 524, 10.1111/all.13944 Gazzinelli-Guimaraes, 2018, Helminth parasites and immune regulation, F1000Res, 7, 10.12688/f1000research.15596.1 Maizels, 2018, Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules, Immunity, 49, 801, 10.1016/j.immuni.2018.10.016 Zaiss, 2016, Interactions between the intestinal microbiome and helminth parasites, Parasite Immunol., 38, 5, 10.1111/pim.12274 Paun, 2015, Immuno-ecology: how the microbiome regulates tolerance and autoimmunity, Curr. Opin. Immunol., 37, 34, 10.1016/j.coi.2015.09.004 Brosschot, 2018, The impact of a helminth-modified microbiome on host immunity, Mucosal Immunol., 11, 1039, 10.1038/s41385-018-0008-5 Lilienthal GM, 2018, Potential of murine IgG1 and human IgG4 to inhibit the classical complement and Fcγ receptor activation pathways, Front. Immunol., 9, 958, 10.3389/fimmu.2018.00958 Nimmerjahn, 2005, Divergent immunoglobulin g subclass activity through selective Fc receptor binding, Science, 310, 1510, 10.1126/science.1118948 Kim, 2012, Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma, PloS One, 7, 10.1371/journal.pone.0035447 Velasquez-Manoff, 2016, The parasite underground Donkers, 2020, Perspectives of people with multiple sclerosis about helminth immunotherapy, Int J MS Care, 22, 43, 10.7224/1537-2073.2019-044