Aversive and non-aversive memory impairment in the mucopolysaccharidosis II mouse model

Metabolic Brain Disease - Tập 33 Số 1 - Trang 343-345 - 2018
Amanda Stapenhorst Azambuja1, Lilian Correa1, Bernardo Pappi Gabiatti2, Giselle Renata Martins2, Álvaro de Oliveira Franco2, Maria Flávia Marques Ribeiro1, Guilherme Baldo2
1Programa de Pós-Graduação em Ciências Biológicas: Fisiologia-UFRGS, Porto Alegre, Brazil
2Centro de Terapia Gênica-HCPA, Ramiro Barcelos, Porto Alegre, RS, 2350, Brazil

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Baldo G, Lorenzini DM, Santos DS, Mayer FQ, Vitry S, Bigou S, Heard JM, Matte U, Giugliani R (2015) Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice. Mol Genet Metab 114(2):138–145

Brusius-Facchin AC, Schwartz IV, Zimmer C, Ribeiro MG, Acosta AX, Horovitz D, Monlleó IL, Fontes MI, Fett-Conte A, Sobrinho RP, Duarte AR, Boy R, Mabe P, Ascurra M, de Michelena M, Tylee KL, Besley GT, Garreton MC, Giugliani R, Leistner-Segal S (2014) Mucopolysaccharidosis type II: identification of 30 novel mutations among Latin American patients. Mol Genet Metab 111(2):133–138

Garcia AR, Pan J, Lamsa JC, Muenzer J (2007) The characterization of a murine model of mucopolysaccharidosis II (hunter syndrome). J Inherit Metab Dis 30(6):924–934

Gleitz HFE et al (2017) Identification of age-dependent motor and neuropsychological behavioural abnormalities in a mouse model of Mucopolysaccharidosis type II. PLoS One 12(2):e0172435

Hinderer C, Katz N, Louboutin JP, Bell P, Yu H, Nayal M, Kozarsky K, O'Brien WT, Goode T, Wilson JM (2016) Delivery of an adeno-associated virus vector into cerebrospinal fluid attenuates central nervous system disease in Mucopolysaccharidosis type II mice. Hum Gene Ther 27(11):906–915

Pan D, Sciascia A 2nd, Vorhees CV, Williams MT (2008) Progression of multiple behavioral deficits with various ages of onset in a murine model of hurler syndrome. Brain Res 1188:241–253

Yund B, Rudser K, Ahmed A, Kovac V, Nestrasil I, Raiman J, Mamak E, Harmatz P, Steiner R, Lau H, Vekaria P, Wozniak JR, Lim KO, Delaney K, Whitley C, Shapiro EG (2015) Cognitive, medical, and neuroimaging characteristics of attenuated mucopolysaccharidosis type II. Mol Genet Metab 114(2):170–177