Autophagy proteins in prostate cancer: Relation with anaerobic metabolism and Gleason score11The study was financially supported by the Tumor and Angiogenesis Research Group.

Xie, 2007, Autophagosome formation: core machinery and adaptations, Nat Cell Biol, 9, 1102, 10.1038/ncb1007-1102 Cao, 2007, Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein, Cell Res, 17, 839, 10.1038/cr.2007.78 Mizushima, 2010, The role of the Atg1/ULK1 complex in autophagy regulation, Curr Opin Cell Biol, 22, 132, 10.1016/j.ceb.2009.12.004 Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J, 19, 5720, 10.1093/emboj/19.21.5720 Pankiv, 2007, p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy, J Biol Chem, 282, 24131, 10.1074/jbc.M702824200 Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018 Rosenfeldt, 2011, The multiple roles of autophagy in cancer, Carcinogenesis, 32, 955, 10.1093/carcin/bgr031 Hippert, 2006, Autophagy in cancer: good, bad, or both?, Cancer Res, 66, 9349, 10.1158/0008-5472.CAN-06-1597 Sivridis, 2012, Patterns of autophagy in urothelial cell carcinomas-the significance of “stone-like” structures (SLS) in transurethral resection biopsies, Urol Oncol Karpathiou, 2011, Light-chain 3A autophagic activity and prognostic significance in non-small cell lung carcinomas, Chest, 140, 127, 10.1378/chest.10-1831 Sivridis, 2011, Autophagy in endometrial carcinomas and prognostic relevance of ‘stone-like’ structures (SLS): what is destined for the atypical endometrial hyperplasia?, Autophagy, 7, 74, 10.4161/auto.7.1.13947 Sivridis, 2010, LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas, Am J Pathol, 176, 2477, 10.2353/ajpath.2010.090049 Toepfer, 2011, Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription, Cancer Biol Ther, 12, 691, 10.4161/cbt.12.8.15978 Xu, 2011, Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin, Prostate, 71, 1216, 10.1002/pros.21337 Suh, 2010, Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells, Carcinogenesis, 31, 1424, 10.1093/carcin/bgq115 Koukourakis, 2006, Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway—a report of the Tumour Angiogenesis Research Group, J Clin Oncol, 24, 4301, 10.1200/JCO.2006.05.9501 Pouysségur, 2001, pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth, Novartis Found Symp, 240, 186, 10.1002/0470868716.ch13 Brown, 1998, The unique physiology of solid tumors: opportunities (and problems) for cancer therapy, Cancer Res, 58, 1408 Rzymski, 2010, Regulation of autophagy by ATF4 in response to severe hypoxia, Oncogene, 29, 4424, 10.1038/onc.2010.191 Hu, 2012, Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma, Cancer Res, 72, 1773, 10.1158/0008-5472.CAN-11-3831 Mikhaylova, 2012, VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma, Cancer Cell, 21, 532, 10.1016/j.ccr.2012.02.019 Koukourakis, 2013, LC3 immunostaining pitfalls, Histopathology, 62, 962, 10.1111/his.12080 Sivridis, 2010, The “stone-like” pattern of autophagy in human epithelial tumors and tumor-like lesions: an approach to the clinical outcome, Autophagy, 6, 830, 10.4161/auto.6.6.12588 Spowart, 2012, The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer, J Pathol, 10.1002/path.4090 Sivridis, 2011, Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1, Melanoma Res, 21, 188, 10.1097/CMR.0b013e328346612c Koukourakis, 2010, Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia, Br J Cancer, 103, 1209, 10.1038/sj.bjc.6605904 Yang, 2011, The role of autophagy in cancer: therapeutic implications, Mol Cancer Ther, 10, 1533, 10.1158/1535-7163.MCT-11-0047 Levy, 2011, Targeting autophagy during cancer therapy to improve clinical outcomes, Pharmacol Ther, 131, 130, 10.1016/j.pharmthera.2011.03.009 Kung, 2011, Targeting tyrosine kinases and autophagy in prostate cancer, Horm Cancer, 2, 38, 10.1007/s12672-010-0053-3