Autophagy in health and disease: A comprehensive review

Biomedicine & Pharmacotherapy - Tập 104 - Trang 485-495 - 2018
Suparna Saha1, Debasna P. Panigrahi1, Shankargouda Patil2, Sujit K. Bhutia1
1Department of Life Science, National Institute of Technology Rourkela, Rourkela, 769008, Odisha, India
2Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Saudi Arabia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Komatsu, 2005, Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice, J. Cell. Biol., 169, 425, 10.1083/jcb.200412022

Tsukada, 1993, Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae, FEBS Lett., 333, 169, 10.1016/0014-5793(93)80398-E

Schmid, 2007, Innate and adaptive immunity through autophagy, Immunity, 27, 11, 10.1016/j.immuni.2007.07.004

He, 2009, Regulation mechanisms and signaling pathways of autophagy, Annu. Rev. Genet., 43, 67, 10.1146/annurev-genet-102808-114910

Levine, 2004, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Dev. Cell, 6, 463, 10.1016/S1534-5807(04)00099-1

Klionsky, 2000, Autophagy as a regulated pathway of cellular degradation, Science, 290, 1717, 10.1126/science.290.5497.1717

Yorimitsu, 2005, Autophagy: molecular machinery for self-eating, Cell. Death Differ. Suppl., 2, 1542, 10.1038/sj.cdd.4401765

Glick, 2010, Autophagy: cellular and molecular mechanisms, J. Pathol., 221, 3, 10.1002/path.2697

Panda, 2015, Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics, Semin. Cell Dev. Biol., 39, 43, 10.1016/j.semcdb.2015.02.013

Ganley, 2013, Autophagosome maturation and lysosomal fusion, Essays Biochem., 55, 65, 10.1042/bse0550065

Cheng, 2005, Role of insulin/insulin-like growth factor 1 signaling pathway in longevity, World J. Gastroenterol., 11, 1891, 10.3748/wjg.v11.i13.1891

Cuervo, 2005, Autophagy and aging: the importance of maintaining "clean" cells, Autophagy, 1, 131, 10.4161/auto.1.3.2017

Vellai, 2003, Genetics: influence of TOR kinase on lifespan in C. elegans, Nature, 426, 620, 10.1038/426620a

Donati, 2004, Anti-aging effects of anti-lipolytic drugs, Exp. Gerontol., 39, 1061, 10.1016/j.exger.2004.03.025

Lee, 2008, A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, Proc. Natl. Acad. Sci. U. S. A., 105, 3374, 10.1073/pnas.0712145105

Zhou, 2017, Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging, Aging (Albany NY), 9, 583, 10.18632/aging.101181

Li, 2017, Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers, Exp. Gerontol., 102, 19, 10.1016/j.exger.2017.11.022

Zhang, 2017, Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging, Biochim. Biophys. Acta, 1863, 1919, 10.1016/j.bbadis.2017.03.016

Ghosh, 2016, Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue, Aging (Albany NY), 8, 2525, 10.18632/aging.101083

Zhai, 2015, GSK-3β activates autophagy and protects against cardiac aging through Ulk1, Circulation, 132, 10.1161/circ.132.suppl_3.16161

Cordani, 2017, Molecular interplay between mutant p53 proteins and autophagy in cancer cells, Biochim. Biophys. Acta, 1867, 19

Liang, 1999, Induction of autophagy and inhibition of tumorigenesis by beclin 1, Nature, 402, 672, 10.1038/45257

Henson, 2017, EGFR family members’ regulation of autophagy is at a crossroads of cell survival and death in cancer, Cancers (Basel), 9, 10.3390/cancers9040027

Mariño, 2007, Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin–3, J. Biol. Chem., 282, 18573, 10.1074/jbc.M701194200

Liao, 2018, Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation, Biomed. Pharmacother., 97, 1341, 10.1016/j.biopha.2017.11.024

Naik, 2018, Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma, Cell Prolif., 51, e12411, 10.1111/cpr.12411

Fesler, 2017, Autophagy regulated by miRNAs in colorectal cancer progression and resistance, Cancer Transl. Med., 3, 96, 10.4103/ctm.ctm_64_16

Zhu, 2017, Autophgay activated by the c-Jun N-terminal kinase-mediated pathway protects human prostate cancer PC3 cells from celecoxib-induced apoptosis, Exp. Ther. Med., 13, 2348, 10.3892/etm.2017.4287

Morita, 2018, PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth, Cancer Cell, 33, 355, 10.1016/j.ccell.2018.02.004

Victor, 2015, Glutaminolysis and autophagy in cancer, Autophagy, 11, 1198, 10.1080/15548627.2015.1053680

Deretic, 2018, Autophagy balances inflammation in innate immunity, Autophagy, 1

Marissa, 2018, The autophagic network and cancer, Nat. Cell Biol., 20, 243, 10.1038/s41556-018-0042-2

Mowers, 2018, Functions of autophagy in the tumor microenvironment and cancer metastasis, FEBS. J., 10.1111/febs.14388

Tong-Hong, 2016, Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition, Oncotarget, 7, 43588, 10.18632/oncotarget.9635

Yang, 2010, Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance, Cell Metab., 11, 467, 10.1016/j.cmet.2010.04.005

Kaniuk, 2007, Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy, Diabetes, 56, 930, 10.2337/db06-1160

Robert, 2015, Unfolding the role of stress response signaling in endocrine resistant breast cancers, Front. Oncol., 5, 140

Quan, 2012, Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice, Diabetologia, 55, 392, 10.1007/s00125-011-2350-y

Cheng, 2013, Therapeutic targeting of autophagy in disease: biology and pharmacology, Pharmacol. Rev., 65, 1162, 10.1124/pr.112.007120

Goldman, 2010, Autophagy and adipogenesis: implications in obesity and type II diabetes, Autophagy, 6, 179, 10.4161/auto.6.1.10814

Jung, 2008, Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia, Cell Metab., 8, 318, 10.1016/j.cmet.2008.08.013

Masini, 2009, Autophagy in human type 2 diabetes pancreatic beta cells, Diabetologia, 52, 1083, 10.1007/s00125-009-1347-2

Candeias, 2017, Brain GLP–1/IGF–1 signaling and autophagy mediate exendin–4 protection against apoptosis in type 2 diabetic rats, Mol. Neurobiol., 55, 4030

Kim, 2013, Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine, Nat. Med., 19, 83, 10.1038/nm.3014

Kruse, 2017, K, intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with type 2 diabetes, Clin. Sci. (Lond.), 131, 37, 10.1042/CS20160736

Takahama, 2018, Autophagy limits activation of the inflammasomes, Immunol. Rev., 281, 62, 10.1111/imr.12613

Into, 2012, Autophagy in regulation of Toll-like receptor signaling, Cell Signal., 24, 1150, 10.1016/j.cellsig.2012.01.020

Oka, 2012, Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure, Nature, 485, 251, 10.1038/nature10992

Mawatwal, 2017, Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner, Biochim. Biophys. Acta, 1861, 3190, 10.1016/j.bbagen.2017.09.010

Cuervo, 2004, Autophagy: in sickness and in health, Trends Cell Biol., 14, 70, 10.1016/j.tcb.2003.12.002

Tallóczy, 2002, Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway, Proc. Natl. Acad. Sci. U. S. A., 99, 190, 10.1073/pnas.012485299

Lee, 2010, In vivo requirement for Atg5 in antigen presentation by dendritic cells, Immunity, 32, 227, 10.1016/j.immuni.2009.12.006

Harris, 2007, T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis, Immunity, 27, 505, 10.1016/j.immuni.2007.07.022

Deretic, 2018, Autophagy balances inflammation in innate immunity, Autophagy, 1

Choi, 2011, Autophagy in inflammatory diseases, Int. J. Cell Biol., 732798

Xu, 2007, Toll-like receptor 4 is a sensor for autophagy associated with innate immunity, Immunity, 27, 135, 10.1016/j.immuni.2007.05.022

Saitoh, 2010, Regulation of innate immune responses by autophagy-related proteins, J. Cell Biol., 189, 925, 10.1083/jcb.201002021

Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980

Tal, 2009, Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling, Proc. Natl. Acad. Sci. U. S. A., 106, 2770, 10.1073/pnas.0807694106

Lee, 2012, Autophagy suppresses interleukin–1β (IL–1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways, J. Biol. Chem., 287, 4033, 10.1074/jbc.M111.280065

Paludan, 2005, Endogenous MHC class II processing of a viral nuclear antigen after autophagy, Science, 307, 593, 10.1126/science.1104904

Henckaerts, 2011, Genetic variation in the autophagy gene ULK1 and risk of Crohn’s disease, Inflamm. Bowel Dis., 17, 1392, 10.1002/ibd.21486

Qiao, 2015, CNTNAP3 associated ATG16L1 expression and Crohn's disease, Mediators Inflamm., 404185

Rioux, 2007, Genome-wide association study identifies five novel susceptibility loci for Crohn’s disease and implicates a role for autophagy in disease pathogenesis, Nat. Genet., 39, 596, 10.1038/ng2032

Bai, 2017, Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/β-catenin signaling in Crohn’s disease, Biochem. Biophys. Res. Commun., 485, 635, 10.1016/j.bbrc.2017.02.034

Settembre, 2008, Lysosomal storage diseases as disorders of autophagy, Autophagy, 4, 113, 10.4161/auto.5227

Malicdan, 2008, Lysosomal myopathies:an excessive build-up in autophagosomes is too much to handle, Neuromuscul. Disord., 18, 521, 10.1016/j.nmd.2008.04.010

Settembre, 2008, A block of autophagy in lysosomal storage disorders, Hum. Mol. Genet., 17, 119, 10.1093/hmg/ddm289

Huynh, 2007, LAMP proteins are required for fusion of lysosomes with phagosomes, EMBO J., 26, 313, 10.1038/sj.emboj.7601511

Hashem, 2017, Impaired mitophagy facilitates mitochondrial damage in Danon disease, J. Mol. Cell. Cardiol., 108, 86, 10.1016/j.yjmcc.2017.05.007

Basile, 2018, Efficient therapy for refractory Pompe disease by mannose 6-phosphate analogue grafting on acid α-glucosidase, J. Controlled Release, 269, 15, 10.1016/j.jconrel.2017.10.043

Raben, 2010, Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder–murine Pompe disease, Autophagy, 6, 1078, 10.4161/auto.6.8.13378

Lim, 2017, Modulation of mTOR signaling as a strategy for the treatment of Pompe disease, EMBO Mol. Med., 9, 353, 10.15252/emmm.201606547

Vaccaro, 2010, Saposin C mutations in Gaucher disease patients resulting in lysosomal lipid accumulation, saposin C deficiency, but normal prosaposin processing and sorting, Hum. Mol. Genet., 19, 2987, 10.1093/hmg/ddq204

Voit, 2017, Mechanisim of autophagy-lysosomal pathway dysfunction in Gaucher disease iPSC neurons, Neurology, 88

Sacheck, 2007, Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases, FASEB J., 21, 140, 10.1096/fj.06-6604com

Buj-Bello, 2002, The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice, Proc. Natl. Acad. Sci. U. S. A., 99, 15060, 10.1073/pnas.212498399

Tanaka, 2000, Accumulation of autophagic vacuoles and cardiomyopathy in LAMP–2-deficient mice, Nature, 406, 902, 10.1038/35022595

Suzuki, 2002, The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy, J. Biochem., 131, 647, 10.1093/oxfordjournals.jbchem.a003147

Long, 2013, Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation, Circ. Res., 112, 1159, 10.1161/CIRCRESAHA.111.300483

Mere, 2017, Muscle ULK1 and ULK2 modulate different aspects of autophagy and are required for atrophy during fasting, FASEB. J., 31, Ib784, 10.1096/fasebj.31.1_supplement.lb784

Terman, 2005, Autophagy in cardiac myocyte homeostasis, aging, and pathology, Cardiovasc. Res., 68, 355, 10.1016/j.cardiores.2005.08.014

Nakai, 2007, The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress, Nat. Med., 13, 619, 10.1038/nm1574

Hamacher-Brady, 2007, Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy, Cell Death Differ., 14, 146, 10.1038/sj.cdd.4401936

Munteanu, 2017, Cardiac autophagic vacuolation in severe X-linked myopathy with excessive autophagy, Neuromuscul. Disord., 27, 185, 10.1016/j.nmd.2016.10.007

Li, 2017, miR–199a impairs autophagy and induces cardiac hypertrophy through mTOR activation, Cell Death Differ., 24, 1205, 10.1038/cdd.2015.95

Høyer-Hansen, 2007, Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta,and Bcl–2, Mol. Cell, 25, 193, 10.1016/j.molcel.2006.12.009

Khadour, 2002, Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats, Am. J. Physiol. Heart Circ. Physiol., 283, H1108, 10.1152/ajpheart.00549.2001

Valentim, 2006, Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury, J. Mol. Cell. Cardiol., 40, 846, 10.1016/j.yjmcc.2006.03.428

Abdullah, 2015, Parkinson's disease and age: the obvious but largely unexplored link, Exp. Gerontol., 68, 33, 10.1016/j.exger.2014.09.014

Alcalay, 2010, Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study, Arch. Neurol., 67, 1116, 10.1001/archneurol.2010.194

Cai, 2016, Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders, Autophagy, 12, 225, 10.1080/15548627.2015.1121360

Kesidou, 2013, Autophagy and neurodegenerative disorders, Neural. Regen. Res., 8, 2275

Cuervo, 2004, Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy, Science, 305, 1292, 10.1126/science.1101738

Nah, 2015, Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach, Mol. Cells, 38, 381, 10.14348/molcells.2015.0034

Coune, 2011, Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson’s disease, J. Parkinsons Dis., 1, 373, 10.3233/JPD-2011-11058

Du, 2010, Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation, Mol. Biol. Cell, 21, 2128, 10.1091/mbc.e10-03-0200

Sala, 2014, Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson’s disease, Brain Res., 1546, 46, 10.1016/j.brainres.2013.12.017

Polymeropoulos, 1997, Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease, Science, 276, 2045, 10.1126/science.276.5321.2045

Winslow, 2010, α-Synuclein impairs macroautophagy: implications for Parkinson's disease, J. Cell Biol., 190, 1023, 10.1083/jcb.201003122

Alvarez-Erviti, 2013, Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson’s disease, Cell Death Dis., 4, e545, 10.1038/cddis.2013.73

Huett, 2010, A systems biology viewpoint on autophagy in health and disease, Curr. Opin. Gastroenterol., 26, 302, 10.1097/MOG.0b013e32833ae2ed

Michiorri, 2010, The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy, Cell Death Differ., 17, 962, 10.1038/cdd.2009.200

Su, 2017, Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: implications for Parkinson's disease, CNS Neurosci. Ther., 23, 717, 10.1111/cns.12721

Esteves, 2018, Mitochondrial metabolism regulates microtubule acetylome and autophagy trough sirtuin–2: impact for Parkinson’s disease, Mol. Neurobiol., 55, 1440, 10.1007/s12035-017-0420-y

Rajawat, 2008, Autophagy in aging and in neurodegenerative disorders, Hormones (Athens), 7, 46, 10.14310/horm.2002.1111037

Hamano, 2008, Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression, Eur. J. Neurosci., 27, 1119, 10.1111/j.1460-9568.2008.06084.x

D’Adamio, 2013, Presenilin-ryanodine receptor connection, Proc. Natl. Acad. Sci. U. S. A., 110, 14825, 10.1073/pnas.1313996110

Lee, 2010, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations, Cell, 141, 1146, 10.1016/j.cell.2010.05.008

Caccamo, 2010, Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments, J. Biol. Chem., 285, 13107, 10.1074/jbc.M110.100420

Sapp, 1997, Huntingtin localization in brains of normal and Huntington's disease patients, Ann. Neurol., 42, 604, 10.1002/ana.410420411

Hoffner, 2002, Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease, J. Cell Sci., 115, 941, 10.1242/jcs.115.5.941

Ravikumar, 2005, Dynein mutations impair autophagic clearance of aggregate-prone proteins, Nat. Genet., 37, 771, 10.1038/ng1591

Wold, 2016, ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models, Mol. Neurodegener., 11, 76, 10.1186/s13024-016-0141-0

Atwal, 2008, A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy, Autophagy, 4, 91, 10.4161/auto.5201

Ravikumar, 2002, Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy, Hum. Mol. Genet., 11, 1107, 10.1093/hmg/11.9.1107

Ravikumar, 2004, Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease, Nat. Genet., 36, 585, 10.1038/ng1362

Yamamoto, 2006, Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway, J. Cell Biol., 172, 719, 10.1083/jcb.200510065

Lim, 2017, Atg5(flox)-derived autophagy-deficient model of pompe disease: does it tell the whole story?, Mol. Ther. Methods Clin. Dev., 7, 11, 10.1016/j.omtm.2017.08.002