Autophagy and the Integrated Stress Response

Molecular Cell - Tập 40 Số 2 - Trang 280-293 - 2010
Guido Kroemer1,2,3,4,5, Guillermo Mariño2,3, Beth Levine6,7,8
1Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Médecine, 75006, Paris, France
2INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France
3Metabolomics Platform, Institut Gustave Roussy, Pavillon de Recherche 1, 94805 Villejuif, France
4Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 20 rue Leblanc, 75015 Paris, France
5Université Paris Descartes, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France
6Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
7Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
8Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Alexander, 2010, ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS, Proc. Natl. Acad. Sci. USA, 107, 4153, 10.1073/pnas.0913860107

Axe, 2008, Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum, J. Cell Biol., 182, 685, 10.1083/jcb.200803137

Baud, 2009, Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls, Nat. Rev. Drug Discov., 8, 33, 10.1038/nrd2781

Behrends, 2010, Network organization of the human autophagy system, Nature, 466, 68, 10.1038/nature09204

Bellot, 2009, Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains, Mol. Cell. Biol., 29, 2570, 10.1128/MCB.00166-09

Bensaad, 2009, Modulation of intracellular ROS levels by TIGAR controls autophagy, EMBO J., 28, 3015, 10.1038/emboj.2009.242

Betin, 2009, Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis, J. Cell Sci., 122, 2554, 10.1242/jcs.046250

Bonnet, 2000, PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex, Mol. Cell. Biol., 20, 4532, 10.1128/MCB.20.13.4532-4542.2000

Boya, 2005, Inhibition of macroautophagy triggers apoptosis, Mol. Cell. Biol., 25, 1025, 10.1128/MCB.25.3.1025-1040.2005

Buchberger, 2010, Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms, Mol. Cell, 40, 238, 10.1016/j.molcel.2010.10.001

Copetti, 2009, p65/RelA modulates BECN1 transcription and autophagy, Mol. Cell. Biol., 29, 2594, 10.1128/MCB.01396-08

Criollo, 2010, The IKK complex contributes to the induction of autophagy, EMBO J., 29, 619, 10.1038/emboj.2009.364

Deng, 2004, Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2, Mol. Cell. Biol., 24, 10161, 10.1128/MCB.24.23.10161-10168.2004

Di Bartolomeo, 2010, The dynamic interaction of Ambra1 with the dynein motor complex regulates mammalian autophagy, J. Cell Biol., 191, 155, 10.1083/jcb.201002100

Efeyan, 2010, mTOR and cancer: many loops in one pathway, Curr. Opin. Cell Biol., 22, 169, 10.1016/j.ceb.2009.10.007

Eisenberg, 2009, Induction of autophagy by spermidine promotes longevity, Nat. Cell Biol., 11, 1305, 10.1038/ncb1975

Furuya, 2010, Negative regulation of Vps34 by Cdk mediated phosphorylation, Mol. Cell, 38, 500, 10.1016/j.molcel.2010.05.009

Gan, 2008, FIP200, a key signaling node to coordinately regulate various cellular processes, Cell. Signal., 20, 787, 10.1016/j.cellsig.2007.10.021

Geisler, 2010, PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1, Nat. Cell Biol., 12, 119, 10.1038/ncb2012

Green, 2009, Cytoplasmic functions of the tumour suppressor p53, Nature, 458, 1127, 10.1038/nature07986

Gutierrez, 2004, Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages, Cell, 119, 753, 10.1016/j.cell.2004.11.038

Haigis, 2010, Mammalian sirtuins: biological insights and disease relevance, Annu. Rev. Pathol., 5, 253, 10.1146/annurev.pathol.4.110807.092250

Hailey, 2010, Mitochondria supply membranes for autophagosome biogenesis during starvation, Cell, 141, 656, 10.1016/j.cell.2010.04.009

Harding, 2003, An integrated stress response regulates amino acid metabolism and resistance to oxidative stress, Mol. Cell, 11, 619, 10.1016/S1097-2765(03)00105-9

Harrison, 2008, DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing, J. Biol. Chem., 283, 9999, 10.1074/jbc.M706040200

Hayashi-Nishino, 2009, A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation, Nat. Cell Biol., 11, 1433, 10.1038/ncb1991

He, 2009, Regulation mechanisms and signaling pathways of autophagy, Annu. Rev. Genet., 43, 67, 10.1146/annurev-genet-102808-114910

He, 2010, The Beclin 1 interactome, Curr. Opin. Cell Biol., 22, 140, 10.1016/j.ceb.2010.01.001

Herrero-Martin, 2009, TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells, EMBO J., 28, 677, 10.1038/emboj.2009.8

Hetz, 2009, Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome, Mol. Cell, 35, 551, 10.1016/j.molcel.2009.08.021

Hetz, 2009, XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy, Genes Dev., 23, 2294, 10.1101/gad.1830709

Hotamisligil, 2010, Endoplasmic reticulum stress and the inflammatory basis of metabolic disease, Cell, 140, 900, 10.1016/j.cell.2010.02.034

Huang, 2009, A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress, Cell Death Differ., 16, 264, 10.1038/cdd.2008.151

Kimball, 2003, Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes, Am. J. Physiol. Cell Physiol., 284, C273, 10.1152/ajpcell.00314.2002

Kirkin, 2009, A role for ubiquitin in selective autophagy, Mol. Cell, 34, 259, 10.1016/j.molcel.2009.04.026

Komatsu, 2010, The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1, Nat. Cell Biol., 12, 213, 10.1038/ncb2021

Kouroku, 2007, ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation, Cell Death Differ., 14, 230, 10.1038/sj.cdd.4401984

Kroemer, 2007, Mitochondrial membrane permeabilization in cell death, Physiol. Rev., 87, 99, 10.1152/physrev.00013.2006

Kume, 2010, Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney, J. Clin. Invest., 120, 1043, 10.1172/JCI41376

Lan, 2008, SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation, J. Biol. Chem., 283, 27628, 10.1074/jbc.M805711200

Lee, 2008, A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, Proc. Natl. Acad. Sci. USA, 105, 3374, 10.1073/pnas.0712145105

Lee, 2009, Regulation of autophagy by the p300 acetyltransferase, J. Biol. Chem., 284, 6322, 10.1074/jbc.M807135200

Lee, 2009, FLIP-mediated autophagy regulation in cell death control, Nat. Cell Biol., 11, 1355, 10.1038/ncb1980

Lee, 2010, HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy, EMBO J., 29, 969, 10.1038/emboj.2009.405

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Liang, 2007, The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis, Nat. Cell Biol., 9, 218, 10.1038/ncb1537

Lipinski, 2010, A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions, Dev. Cell, 18, 1041, 10.1016/j.devcel.2010.05.005

Liu, 2008, Hypoxic reactive oxygen species regulate the integrated stress response and cell survival, J. Biol. Chem., 283, 31153, 10.1074/jbc.M805056200

Madeo, 2010, Does autophagy induction prolong longevity?, Nat. Cell Biol., 11, 942

Maiuri, 2007, Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1, EMBO J., 26, 2527, 10.1038/sj.emboj.7601689

Majmundar, 2010, Hypoxia-inducible factors and the response to hypoxic stress, Mol. Cell, 40, 294, 10.1016/j.molcel.2010.09.022

Mammucari, 2007, FoxO3 controls autophagy in skeletal muscle in vivo, Cell Metab., 6, 458, 10.1016/j.cmet.2007.11.001

Mathew, 2009, Autophagy suppresses tumorigenesis through elimination of p62, Cell, 137, 1062, 10.1016/j.cell.2009.03.048

Mazure, 2010, Hypoxia-induced autophagy: cell death or cell survival?, Curr. Opin. Cell Biol., 22, 177, 10.1016/j.ceb.2009.11.015

Michiorri, 2010, The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy, Cell Death Differ., 17, 962, 10.1038/cdd.2009.200

Milani, 2009, The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib, Cancer Res., 69, 4415, 10.1158/0008-5472.CAN-08-2839

Mizushima, 2010, The role of the Atg1/ULK1 complex in autophagy regulation, Curr. Opin. Cell Biol., 22, 132, 10.1016/j.ceb.2009.12.004

Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639

Mizushima, 2010, Methods in mammalian autophagy research, Cell, 140, 313, 10.1016/j.cell.2010.01.028

Morselli, 2010, Caloric restriction and resveratrol prolong longevity via the sirtuin-1 dependent induction of autophagy, Cell Death Disease, 1, e10, 10.1038/cddis.2009.8

Nakamura, 2010, Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis, Cell, 140, 338, 10.1016/j.cell.2010.01.001

Narendra, 2010, PINK1 is selectively stabilized on impaired mitochondria to activate Parkin, PLoS Biol., 8, e1000298, 10.1371/journal.pbio.1000298

Nasrin, 2009, JNK1 phosphorylates SIRT1 and promotes its enzymatic activity, PLoS ONE, 4, e8414, 10.1371/journal.pone.0008414

Neufeld, 2010, TOR-dependent control of autophagy: biting the hand that feeds, Curr. Opin. Cell Biol., 22, 157, 10.1016/j.ceb.2009.11.005

Nivon, 2009, Autophagy activation by NFkappaB is essential for cell survival after heat shock, Autophagy, 5, 766, 10.4161/auto.8788

Novak, 2010, Nix is a selective autophagy receptor for mitochondrial clearance, EMBO Rep., 11, 45, 10.1038/embor.2009.256

Orsi, 2010, Membrane trafficking events that partake in autophagy, Curr. Opin. Cell Biol., 22, 150, 10.1016/j.ceb.2009.11.013

Pattingre, 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, Cell, 122, 927, 10.1016/j.cell.2005.07.002

Pattingre, 2009, Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy, J. Biol. Chem., 284, 2719, 10.1074/jbc.M805920200

Polson, 2010, Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation, Autophagy, 6, 10.4161/auto.6.4.11863

Qing, 2007, Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation, Cell Res., 17, 520, 10.1038/cr.2007.47

Ravikumar, 2010, Plasma membrane contributes to the formation of pre-autophagosomal structures, Nat. Cell Biol., 12, 747, 10.1038/ncb2078

Rouschop, 2010, The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5, J. Clin. Invest., 120, 127, 10.1172/JCI40027

Ruderman, 2010, AMPK and SIRT1: a long-standing partnership?, Am. J. Physiol. Endocrinol. Metab., 298, E751, 10.1152/ajpendo.00745.2009

Saitoh, 2009, Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response, Proc. Natl. Acad. Sci. USA, 106, 10842, 10.1073/pnas.0911267106

Sandoval, 2008, Essential role for Nix in autophagic maturation of erythroid cells, Nature, 454, 232, 10.1038/nature07006

Sarkar, 2007, Small molecules enhance autophagy and reduce toxicity in Huntington's disease models, Nat. Chem. Biol., 3, 331, 10.1038/nchembio883

Scherz-Shouval, 2007, Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4, EMBO J., 26, 1749, 10.1038/sj.emboj.7601623

Sengupta, 2010, Regulation of the mTor complex 1 by nutrients, growth factors, and stress, Mol. Cell, 40, 310, 10.1016/j.molcel.2010.09.026

Shi, 2008, MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages, J. Biol. Chem., 283, 33175, 10.1074/jbc.M804478200

Shi, 2010, TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy, Sci. Signal., 3, ra42, 10.1126/scisignal.2000751

Sumpter, 2010, Autophagy and innate immunity: triggering, targeting and tuning, Semin. Cell. Dev. Biol., 21, 699, 10.1016/j.semcdb.2010.04.003

Talloczy, 2002, Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway, Proc. Natl. Acad. Sci. USA, 99, 190, 10.1073/pnas.012485299

Talloczy, 2006, PKR-dependent autophagic degradation of herpes simplex virus type 1, Autophagy, 2, 24, 10.4161/auto.2176

Vicencio, 2009, The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1, Cell Death Differ., 16, 1006, 10.1038/cdd.2009.34

Virgin, 2009, Autophagy genes in immunity, Nat. Immunol., 10, 461, 10.1038/ni.1726

Webber, 2010, Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP, EMBO J., 29, 27, 10.1038/emboj.2009.321

Wei, 2008, JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy, Mol. Cell, 30, 678, 10.1016/j.molcel.2008.06.001

Weidberg, 2010, LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis, EMBO J., 29, 1792, 10.1038/emboj.2010.74

Williams, 2008, Novel targets for Huntington's disease in an mTOR-independent autophagy pathway, Nat. Chem. Biol., 4, 295, 10.1038/nchembio.79

Wirawan, 2010, Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria, Cell Death Disease, 1, e18, 10.1038/cddis.2009.16

Wong, 2010, Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation, PLoS ONE, 5, e9996, 10.1371/journal.pone.0009996

Xia, 2010, Control of basal autophagy by calpain1 mediated cleavage of ATG5, Autophagy, 6, 61, 10.4161/auto.6.1.10326

Yang, 2010, Mammalian autophagy: core molecular machinery and signaling regulation, Curr. Opin. Cell Biol., 22, 124, 10.1016/j.ceb.2009.11.014

Yang, 2010, Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance, Cell Metab., 11, 467, 10.1016/j.cmet.2010.04.005

Yla-Anttila, 2009, 3D tomography reveals connections between the phagophore and endoplasmic reticulum, Autophagy, 5, 1180, 10.4161/auto.5.8.10274

Yousefi, 2006, Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis, Nat. Cell Biol., 8, 1124, 10.1038/ncb1482

Zalckvar, 2009, DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy, EMBO Rep., 10, 285, 10.1038/embor.2008.246

Zhao, 2010, Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity, Nat. Cell Biol., 12, 665, 10.1038/ncb2069