Autophagy and doxorubicin resistance in cancer

Dalton, 1997, Mechanisms of drug resistance in hematologic malignancies, Semin Hematol, 34, 3

Young, 2003, Efflux transporters of the human placenta, Adv Drug Deliv Rev, 55, 125, 10.1016/S0169-409X(02)00174-6

Meredith, 2016, Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism, J Pharm Pharmacol, 68, 729, 10.1111/jphp.12539

Ogura, 2001, Adriamycin (doxorubicin), Gan To Kagaku Ryoho, 28, 1331

Zhao, 2016, Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance, Sci Rep, 6, 35267, 10.1038/srep35267

Kruh, 1993, Doxorubicin and multidrug resistance, Curr Opin Oncol, 5, 1029, 10.1097/00001622-199311000-00014

Ueda, 1987, The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation, J Biol Chem, 262, 505, 10.1016/S0021-9258(19)75806-2

Cole, 1992, Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line, Science, 258, 1650, 10.1126/science.1360704

Longhurst, 1996, The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line, Br J Cancer, 74, 1331, 10.1038/bjc.1996.545

Slovak, 1995, The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification, Cancer Res, 55, 4214

Wang, 2016, COUP-TFII suppresses colorectal carcinoma resistance to doxorubicin involving inhibition of epithelial–mesenchymal transition, Am J Transl Res, 8, 3921

Saxena, 2011, Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters, Cell Death Dis, 2, e179, 10.1038/cddis.2011.61

Xu, 2017, Resveratrol reverses doxorubicin resistance by inhibiting epithelial–mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer, J Exp Clin Cancer Res, 36, 19, 10.1186/s13046-016-0487-8

Xu, 2016, ARK5 promotes doxorubicin resistance in hepatocellular carcinoma via epithelial–mesenchymal transition, Cancer Lett, 377, 140, 10.1016/j.canlet.2016.04.026

Withoff, 1996, Human DNA topoisomerase II: biochemistry and role in chemotherapy resistance (review), Anticancer Res, 16, 1867

Shukla, 2010, Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin, Mol Cancer, 9, 314, 10.1186/1476-4598-9-314

Singh, 1989, Glutathione S-transferases and glutathione peroxidases in doxorubicin-resistant murine leukemic P388 cells, Biochem Pharmacol, 38, 3505, 10.1016/0006-2952(89)90121-4

Krishna, 2000, Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs, Eur J Pharm Sci, 11, 265, 10.1016/S0928-0987(00)00114-7

Hu, 2016, Mechanisms of drug resistance in colon cancer and its therapeutic strategies, World J Gastroenterol, 22, 6876, 10.3748/wjg.v22.i30.6876

Holohan, 2013, Cancer drug resistance: an evolving paradigm, Nat Rev Cancer, 13, 714, 10.1038/nrc3599

Giacomini, 2010, Membrane transporters in drug development, Nat Rev Drug Discov, 9, 215, 10.1038/nrd3028

Bogush, 2003, A novel marker of multiple drug resistance BCRP, Antibiot Khimioter, 48, 33

Duan, 2015, Potent and selective inhibition of plasma membrane monoamine transporter by HIV Protease inhibitors, Drug Metab Dispos, 43, 1773, 10.1124/dmd.115.064824

Fernald, 2013, Evading apoptosis in cancer, Trends Cell Biol, 23, 620, 10.1016/j.tcb.2013.07.006

Rathore, 2017, Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs), Apoptosis, 22, 898, 10.1007/s10495-017-1375-1

Liu, 2011, DAMP-mediated autophagy contributes to drug resistance, Autophagy, 7, 112, 10.4161/auto.7.1.14005

Yan, 2015, Interplay between unfolded protein response and autophagy promotes tumor drug resistance, Oncol Lett, 10, 1959, 10.3892/ol.2015.3508

Kumar, 2015, Targeting autophagy to overcome drug resistance in cancer therapy, Future Med Chem, 7, 1535, 10.4155/fmc.15.88

Lin, 2015, Autophagy, cell death, and cancer, Mol Cell Oncol, 2, e985913, 10.4161/23723556.2014.985913

Gottlieb, 2009, Cardioprotection requires taking out the trash, Basic Res Cardiol, 104, 169, 10.1007/s00395-009-0011-9

Glick, 2010, Autophagy: cellular and molecular mechanisms, J Pathol, 221, 3, 10.1002/path.2697

Parzych, 2014, An overview of autophagy: morphology, mechanism, and regulation, Antioxid Redox Signal, 20, 460, 10.1089/ars.2013.5371

Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639

Subramani, 2013, Non-autophagic roles of autophagy-related proteins, EMBO Rep, 14, 143, 10.1038/embor.2012.220

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Yang, 2010, Eaten alive: a history of macroautophagy, Nat Cell Biol, 12, 814, 10.1038/ncb0910-814

Dirks-Naylor, 2013, The role of autophagy in doxorubicin-induced cardiotoxicity, Life Sci, 93, 913, 10.1016/j.lfs.2013.10.013

Thorburn, 2014, Autophagy and cancer therapy, Mol Pharmacol, 85, 830, 10.1124/mol.114.091850

Lekli, 2017, Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias, J Cell Mol Med, 21, 1058, 10.1111/jcmm.13053

Ganley, 2011, Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest, Mol Cell, 42, 731, 10.1016/j.molcel.2011.04.024

Martinez-Outschoorn, 2010, The autophagic tumor stroma model of cancer or ‘battery-operated tumor growth’: a simple solution to the autophagy paradox, Cell Cycle, 9, 4297, 10.4161/cc.9.21.13817

Guo, 2016, Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells, BMC Cancer, 16, 762, 10.1186/s12885-016-2790-3

Huang, 2016, Stress management by autophagy: Implications for chemoresistance, Int J Cancer, 139, 23, 10.1002/ijc.29990

Lin, 2010, Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer, Mol Cancer Res, 8, 1217, 10.1158/1541-7786.MCR-10-0162

Sui, 2013, Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment, Cell Death Dis, 4, e838, 10.1038/cddis.2013.350

Ren, 2016, Novel mechanisms and approaches to overcome multidrug resistance in the treatment of ovarian cancer, Biochim Biophys Acta, 1866, 266

Li, 2017, Autophagy and multidrug resistance in cancer, Chin J Cancer, 36, 52, 10.1186/s40880-017-0219-2

Pan, 2015, Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin, Genet Mol Res, 14, 5621, 10.4238/2015.May.25.14

Tan, 2015, Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy, Cancer Sci, 106, 1023, 10.1111/cas.12712

Ma, 2015, Rapamycin-mediated mTOR inhibition reverses drug resistance to adriamycin in colon cancer cells, Hepatogastroenterology, 62, 880

Yousefi, 2006, Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis, Nat Cell Biol, 8, 1124, 10.1038/ncb1482

Yang, 2013, Application and interpretation of current autophagy inhibitors and activators, Acta Pharmacol Sin, 34, 625, 10.1038/aps.2013.5

Pasquier, 2016, Autophagy inhibitors, Cell Mol Life Sci, 73, 985, 10.1007/s00018-015-2104-y

Towers, 2016, Therapeutic targeting of autophagy, EBioMedicine, 14, 15, 10.1016/j.ebiom.2016.10.034

Wang, 2016, Pharmacological inhibitors of autophagy as novel cancer therapeutic agents, Pharmacol Res, 105, 164, 10.1016/j.phrs.2016.01.028

Aydinlik, 2017, Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line, Biochim Biophys Acta, 1861, 49, 10.1016/j.bbagen.2016.11.013

Majeski, 2004, Mechanisms of chaperone-mediated autophagy, Int J Biochem Cell Biol, 36, 2435, 10.1016/j.biocel.2004.02.013

Massey, 2004, Pathophysiology of chaperone-mediated autophagy, Int J Biochem Cell Biol, 36, 2420, 10.1016/j.biocel.2004.04.010

Saha, 2012, LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy, Autophagy, 8, 1643, 10.4161/auto.21654

Giovane, 1994, Net, a new ets transcription factor that is activated by Ras, Genes Dev, 8, 1502, 10.1101/gad.8.13.1502

Park, 2016, PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting autophagy, Biochem Biophys Res Commun, 477, 277, 10.1016/j.bbrc.2016.06.057

Kang, 2007, Relationship of serum adiponectin and resistin levels with breast cancer risk, J Korean Med Sci, 22, 117, 10.3346/jkms.2007.22.1.117

Liu, 2017, Resistin confers resistance to doxorubicin-induced apoptosis in human breast cancer cells through autophagy induction, Am J Cancer Res, 7, 574

Tang, 2010, Endogenous HMGB1 regulates autophagy, J Cell Biol, 190, 881, 10.1083/jcb.200911078

Liu, 2011, HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells, Leukemia, 25, 23, 10.1038/leu.2010.225

Huang, 2012, HMGB1 promotes drug resistance in osteosarcoma, Cancer Res, 72, 230, 10.1158/0008-5472.CAN-11-2001

Xu, 2016, MicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy, Oncol Rep, 35, 1757, 10.3892/or.2015.4497

Chen, 2017, MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma, Mol Med Rep, 15, 1326, 10.3892/mmr.2017.6149

Chang, 2014, Blocked autophagy by miR-101 enhances osteosarcoma cell chemosensitivity in vitro, ScientificWorldJournal, 2014, 794756, 10.1155/2014/794756

Wang, 2017, Long non-coding RNA CTA sensitizes osteosarcoma cells to doxorubicin through inhibition of autophagy, Oncotarget, 8, 31465, 10.18632/oncotarget.16356

Jia, 2009, Current evaluation of the millennium phytomedicine- ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine, Curr Med Chem, 16, 2924, 10.2174/092986709788803204

Kim, 2014, 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin, Oncotarget, 5, 4438, 10.18632/oncotarget.2034

Stauffer, 2007, Small molecule inhibition of the Bcl-X(L)-BH3 protein-protein interaction: proof-of-concept of an in vivo chemopotentiator ABT-737, Curr Top Med Chem, 7, 961, 10.2174/156802607780906843

Levine, 2008, Bcl-2 family members: dual regulators of apoptosis and autophagy, Autophagy, 4, 600, 10.4161/auto.6260

Yao, 2017, B-cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carcinoma cells, Tumour Biol, 39, 1010428317695965, 10.1177/1010428317695965

Jin, 2017, MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy, Cell Death Dis, 8, e2540, 10.1038/cddis.2016.461

Hagenbuchner, 2016, Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma, Oncotarget, 7, 77591, 10.18632/oncotarget.12728

Salcher, 2017, C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy, Mol Cancer, 16, 95, 10.1186/s12943-017-0661-4

Bolden, 2006, Anticancer activities of histone deacetylase inhibitors, Nat Rev Drug Discov, 5, 769, 10.1038/nrd2133

Oehme, 2013, Histone deacetylase 10 promotes autophagy-mediated cell survival, Proc Natl Acad Sci USA, 110, E2592, 10.1073/pnas.1300113110

Suh, 2013, A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer, Cancer Lett, 332, 102, 10.1016/j.canlet.2013.01.022

Li, 2014, Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells, Oncol Lett, 8, 1603, 10.3892/ol.2014.2368

Thamilselvan, 2011, Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 beta/beta-catenin pathway, Int J Cancer, 129, 2916, 10.1002/ijc.25949

Cheng, 2013, Acquired multidrug resistance in human K562/ADM cells is associated with enhanced autophagy, Toxicol Mech Methods, 23, 678, 10.3109/15376516.2013.843105

Sardiello, 2009, A gene network regulating lysosomal biogenesis and function, Science, 325, 473, 10.1126/science.1174447

Fang, 2017, Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells, Acta Pharmacol Sin, 38, 1305, 10.1038/aps.2017.25

Seca, 2013, Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells, Curr Drug Targets, 14, 1135, 10.2174/13894501113149990185

Nicholson, 2001, EGFR and cancer prognosis, Eur J Cancer, 37, S9, 10.1016/S0959-8049(01)00231-3

Xu, 2011, Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin, Prostate, 71, 1216, 10.1002/pros.21337

Westhoff, 2013, Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma, PLoS One, 8, e83128, 10.1371/journal.pone.0083128

Lin, 2009, Autophagy: a new target for advanced papillary thyroid cancer therapy, Surgery, 146, 1208, 10.1016/j.surg.2009.09.019

Kim, 2015, Psammaplin A induces sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts, Biochim Biophys Acta, 1850, 401, 10.1016/j.bbagen.2014.11.007

Meschini, 2007, Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells, Toxicol In Vitro, 21, 197, 10.1016/j.tiv.2006.09.007

Meschini, 2008, The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells, Autophagy, 4, 1020, 10.4161/auto.6952

Meijer, 1997, Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5, Eur J Biochem, 243, 527, 10.1111/j.1432-1033.1997.t01-2-00527.x

Lambert, 2008, Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model, Cancer Res, 68, 7966, 10.1158/0008-5472.CAN-08-1333

Gao, 2017, Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, J Liposome Res, 27, 151, 10.1080/08982104.2016.1185731

Tuteja, 2014, High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm, Clin Pharmacol Ther, 96, 48, 10.1038/clpt.2014.79

Wang, 2014, Combination of apolipoprotein A1-modi liposome-doxorubicin with autophagy inhibitors overcame drug resistance in vitro, J Pharm Sci, 103, 3994, 10.1002/jps.24216

Saiyin, 2014, Sequential release of autophagy inhibitor and chemotherapeutic drug with polymeric delivery system for oral squamous cell carcinoma therapy, Mol Pharm, 11, 1662, 10.1021/mp5000423

Hua, 2017, Seeking new anti-cancer agents from autophagy-regulating natural products, J Asian Nat Prod Res, 19, 305, 10.1080/10286020.2017.1304385

Sun, 2016, Nanoparticle-facilitated autophagy inhibition promotes the efficacy of chemotherapeutics against breast cancer stem cells, Biomaterials, 103, 44, 10.1016/j.biomaterials.2016.06.038

Satoh, 2006, Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives, J Pharmacol Sci, 100, 513, 10.1254/jphs.CPJ06002X

Wei, 2010, C60(Nd) nanoparticles enhance chemotherapeutic susceptibility of cancer cells by modulation of autophagy, Nanotechnology, 21, 495101, 10.1088/0957-4484/21/49/495101

Zhang, 2009, Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal, Autophagy, 5, 1107, 10.4161/auto.5.8.9842

Youle, 2008, The BCL-2 protein family: opposing activities that mediate cell death, Nat Rev Mol Cell Biol, 9, 47, 10.1038/nrm2308

Buchholz, 2003, Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy, Cancer J, 9, 33, 10.1097/00130404-200301000-00007

Tabuchi, 2009, Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer, Int J Oncol, 34, 313

Tekedereli, 2013, Therapeutic silencing of Bcl-2 by systemically administered siRNA nanotherapeutics inhibits tumor growth by autophagy and apoptosis and enhances the efficacy of chemotherapy in orthotopic xenograft models of ER (−) and ER (+) breast cancer, Mol Ther Nucleic Acids, 2, e121, 10.1038/mtna.2013.45

Broxterman, 2009, Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib, Drug Resist Updat, 12, 114, 10.1016/j.drup.2009.07.001

Shi, 2017, Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation, Cell Discov, 3, 17010, 10.1038/celldisc.2017.10