Automatic quantitation of localized in vivo1H spectra with LCModel

NMR in Biomedicine - Tập 14 Số 4 - Trang 260-264 - 2001
Stephen W. Provencher1
1Max-Planck-Institute for Biophysical Chemistry, D-37070, Göttingen, Germany

Tóm tắt

Abstract

The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model‐free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non‐interactive) with no subjective input. Approximately maximum‐likelihood estimates of the metabolite concentrations and their uncertainties (Cramér‐Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS. Copyright © 2001 John Wiley & Sons, Ltd. <bold>Abbreviations used:</bold> Ala

alanine

Asp

aspartate

 Cr

creatine

 GABA

γ‐aminobutyric acid

 Glc

glucose

 Gln

glutamine

 Glu

glutamate

 GPC

glycerophosphocholine

 GSH

glutathione

 Ins

myo‐inositol

 Lac

lactate

 NAA

N‐acetylaspartate

 NAAG

N‐acetylaspartylglutamate

 PC

phosphocholine

 PCr

phosphocreatine

 PE

phosphoethanolamine

 Scyllo

scyllo‐inositol

 S/N

signal‐to‐noise ratio

 Tau

taurine.

Từ khóa


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NMR in Biomedicine

Tập 14 Số 4

260-264

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