Automated synthesis and combinatorial chemistry

Current Opinion in Biotechnology - Tập 6 - Trang 640-645 - 1995
Sheila H DeWitt1, Anthony W Czarnik1
1Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA

Tài liệu tham khảo

Corkan, 1990, Design concepts for synthetic chemistry workstations, 477 Strimaitis, 1989, Robots in the laboratory—an overview, J Chem Edu, 66, A8, 10.1021/ed066pA8 Lindsey, 1992, A retrospective on the automation of laboratory synthetic chemistry, Chemomet Intell Lab Syst, 17, 15, 10.1016/0169-7439(92)90025-B Beugelsdijk, 1991, The future of laboratory automation, Genet Anal Tech Appl, 8, 217, 10.1016/1050-3862(91)90016-K Guette, 1988, Automation in the organic chemistry laboratory: why? How?, Pure Appl Chem, 60, 1669, 10.1351/pac198860111669 Gallop, 1994, Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries, J Med Chem, 37, 1233, 10.1021/jm00035a001 Gordon, 1994, Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions, J Med Chem, 37, 1385, 10.1021/jm00036a001 DeWitt, 1995, Combinatorial chemistry and high-throughput synthesis Corkan, 1992, Application of an automated chemistry workstation to problems in synthetic chemistry, Chemomet Intell Lab Syst, 17, 95, 10.1016/0169-7439(92)90028-E Corkan, 1992, Experiment manager software for an automated chemistry workstation, including a scheduler for parallel experimentation, Chemomet Intell Lab Syst, 17, 47, 10.1016/0169-7439(92)90026-C Josses, 1990, Carrying out multiple reactions in organic synthesis with a robot, Adv Lab Autom Rob, 6, 463 Lantrip, 1989, Controlling the Purdue automated synthesis system, Adv Lab Autom Rob, 5, 115 Matsuda, 1988, Simplex optimization of reaction conditions with an automated system, Chem Pharm Bull, 36, 3512, 10.1248/cpb.36.3512 Metivier, 1992, Automation of organic synthesis in industrial research laboratories, Chemomet Intell Lab Syst, 17, 137, 10.1016/0169-7439(92)90034-D Sugawara, 1994, Development of fully-automated synthesis systems, J Auto Chem, 16, 33, 10.1155/S1463924694000039 Weglarz, 1990, Development of an automated reaction optimization system, Adv Lab Autom Rob, 6, 435 Gausepohl, 1992, Automated multiple peptide synthesis, Pept Res, 5, 315 Schnorrenberg, 1989, Fully automatic simultaneous multiple peptide synthesis in micromolar scale-rapid synthesis of series of peptides for screening in biological assays, Tetrahedron, 45, 6031, 10.1016/S0040-4020(01)85791-4 Gausepohl, 1990, A multiple reaction system for automated simultaneous peptide synthesis, 1003 Zuckermann, 1992, Design construction and application of a fully automated equimolar peptide mixture synthesizer, Int J Pept Protein Res, 40, 497, 10.1111/j.1399-3011.1992.tb00433.x Zuckermann, 1992, Control of the zymate robot with an external computer. Construction of a multiple peptide synthesizer, Lab Rob Autom, 4, 183 Zuckermann, 1992, Automated peptide—resin deprotection/cleavage by a robotic workstation, Pept Res, 5, 169 Frisbee, 1984, Robotic orchestration of organic reactions: yield optimization via an automated system with operator-specific reaction sequences, J Am Chem Soc, 106, 7143, 10.1021/ja00335a047 DeWitt, 1993, The DIVERSOMER approach: integration and automation of multiple, simultaneous solid phase synthesis, 248 DeWitt, 1993, ‘Diversomers’: an approach to nonpeptide, nonoligomeric chemical diversity, Proc Natl Acad Sci USA, 90, 6909, 10.1073/pnas.90.15.6909 DeWitt, 1994, DIVERSOMER™ technology, solid phase synthesis, automation, and integration for the generation of chemical diversity, Drug Dev Res, 33, 116, 10.1002/ddr.430330208 Yu, 1992, Enhanced coupling efficiency in solid-phase peptide synthesis by microwave irradiation, J Org Chem, 57, 4781, 10.1021/jo00044a001 Zuckermann, 1992, Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis, Proc Natl Acad Sci USA, 89, 4505, 10.1073/pnas.89.10.4505 Zuckermann, 1993, The chemical synthesis of peptidomimetic libraries, Curr Opin Struct Biol, 3, 580, 10.1016/0959-440X(93)90086-Z Andrus, 1991, Large scale automated synthesis of oligodeoxyribonucleotides, Nucleic Acids Symp Ser, 24, 41 Kaplan, 1987, DNA synthesis on solid supports and automation, 9 Neimark, 1993, Development of a fully automated multichannel peptide synthesizer with integrated TFA cleavage capability, Pept Res, 6, 219