Autologous Chondrocyte Transplantation

American Journal of Sports Medicine - Tập 30 Số 1 - Trang 2-12 - 2002
Lars Peterson1, Mats Brittberg2, Illka Kiviranta3, Evy Lundgren Åkerlund4, Anders Lindahl5
1Gothenburg Medical Center, Gothenburg University,Gothenburg, Sweden
2Kungsbacka Hospital, Gothenburg University,Gothenburg, Sweden
3Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
4Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
5Institute of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

Tóm tắt

We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years.

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Thông tin xuất bản

American Journal of Sports Medicine

Tập 30 Số 1

2-12

Thông tin tác giả