Viêm gan tự miễn

Springer Science and Business Media LLC - Tập 31 - Trang 421-435 - 2009
Diego Vergani1, Maria Serena Longhi2, Dimitrios P. Bogdanos2, Yun Ma2, Giorgina Mieli-Vergani2
1Institute of Liver Studies, Paediatric Liver Centre, King’s College Hospital, London, UK
2King’s College London School of Medicine, King’s College Hospital, London, UK

Tóm tắt

Viêm gan tự miễn (AIH) là một bệnh gan viêm chủ yếu ảnh hưởng đến nữ giới và được đặc trưng histologically bởi viêm gan interface, về sinh hóa bởi nồng độ transaminase tăng cao và về huyết thanh học bởi sự hiện diện của tự kháng thể và nồng độ immunoglobulin G tăng lên. AIH đáp ứng với điều trị ức chế miễn dịch, điều này nên được thực hiện ngay khi chẩn đoán được xác định. Seropositivity đối với kháng thể cơ trơn và/hoặc kháng thể chống nhân tế bào xác định AIH loại 1, trong khi sự hiện diện của kháng thể microsomal gan thận loại 1 xác định AIH loại 2. Nguyên nhân của AIH chưa được biết đến, mặc dù cả yếu tố di truyền và môi trường đều liên quan đến sự biểu hiện của nó. Các phản ứng miễn dịch chống lại các kháng nguyên gan của cơ thể được cho là cơ chế chính gây tổn thương gan.

Từ khóa

#Viêm gan tự miễn #tự kháng thể #điều trị ức chế miễn dịch #sinh hóa #miễn dịch

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