Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital

Springer Science and Business Media LLC - Tập 42 - Trang 459-470 - 2022
Angélique Chauvineau-Grenier1, Paul Bastard2,3, Antoine Servajean4, Adrian Gervais2,5, Jérémie Rosain2,5, Emmanuelle Jouanguy2,4, Aurélie Cobat2,3, Jean-Laurent Casanova2,3,6, Benjamin Rossi7
1Medical Biology Department, Robert Ballanger Hospital, Aulnay-Sous-Bois, France
2Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France
3St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA
4University of Paris, UFR de Médecine, Paris, France
5University of Paris, Imagine Institute, Paris, France
6Howard Hughes Medical Institute, New York, USA
7Department of Internal Medicine, Robert Ballanger Hospital, Aulnay-Sous-Bois, France

Tóm tắt

Recent studies reported the presence of pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) in at least 15% of patients with critical COVID-19 pneumonia. In one study, these auto-Abs were found in almost 20% of deceased patients across all ages. We aimed to assess the prevalence and clinical impact of the auto-Abs to type I IFNs in the Seine-Saint-Denis district, which was one of the most affected areas by COVID-19 in France during the first wave. We tested for the presence of auto-Abs neutralizing type I IFNs in a cohort of patients admitted for critical COVID-19 pneumonia during the first wave in the spring of 2020 in the medicine departments at Robert Ballanger Hospital, Aulnay sous Bois. We found circulating auto-Abs that neutralized 100 pg/mL IFN-α2 and/or IFN-ω in the plasma (diluted 1/10) of 7.9% (11 of 139) of the patients hospitalized for critical COVID-19. The presence of neutralizing auto-Abs was associated with an increased risk of mortality, as these auto-Abs were detected in 21% of patients who died from COVID-19 pneumonia. Deceased patients with and without auto-Abs did not present overt clinical differences. These results confirm both the importance of type I IFN immunity in host defense against SARS-CoV-2 infection and the usefulness of detection of auto-Abs neutralizing type I IFNs in the management of patients.

Tài liệu tham khảo

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