Atypical cyclins in cancer: New kids on the block?

Seminars in Cell & Developmental Biology - Tập 107 - Trang 46-53 - 2020
Eva Quandt1, Mariana P.C. Ribeiro1, Josep Clotet1
1Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallès, Barcelona, Spain

Tài liệu tham khảo

Evans, 1983, Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division, Cell, 33, 389, 10.1016/0092-8674(83)90420-8 Quandt, 2020, Atypical cyclins: the extended family portrait, Cell. Mol. Life Sci., 77, 231, 10.1007/s00018-019-03262-7 Hydbring, 2016, Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases, Nat. Rev. Mol. Cell Biol., 17, 280, 10.1038/nrm.2016.27 Caldon, 2012, Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast Cancer cells, Mol. Cancer Cell., 11, 1488 Sterlacci, 2010, Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients, J. Thorac. Oncol., 5, 1325, 10.1097/JTO.0b013e3181e77efc Yasui, 2006, Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization, Clin. Cancer Res., 12, 4720, 10.1158/1078-0432.CCR-05-1213 Cooper, 2009, Expression and prognostic significance of cyclin B1 and cyclin A in non-small cell lung cancer, Histopathology, 55, 28, 10.1111/j.1365-2559.2009.03331.x Li, 2014, Prognostic significance of cyclin D1 expression in colorectal Cancer: a meta-analysis of observational studies, PLoS One, 9 Choi, 2009, Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression, J. Surg. Res., 157, 168, 10.1016/j.jss.2008.06.020 Musgrove, 2011, Cyclin D as a therapeutic target in cancer, Nat. Rev. Cancer, 11, 558, 10.1038/nrc3090 Choi, 2012, The requirement for cyclin d function in tumor maintenance, Cancer Cell, 22, 438, 10.1016/j.ccr.2012.09.015 Tarn, 2011, Translational control of cyclins, Cell Div., 6, 5, 10.1186/1747-1028-6-5 Chen, 2002, Discordant Protein and mRNA Expression in Lung Adenocarcinomas, Mol. Cell Proteomics, 1, 304, 10.1074/mcp.M200008-MCP200 Li, 2014, Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact, Nat. Commun., 5, 5469, 10.1038/ncomms6469 Schwanhäusser, 2011, Global quantification of mammalian gene expression control, Nature, 473, 337, 10.1038/nature10098 Nagy, 2018, Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets, Sci. Rep., 8, 9227, 10.1038/s41598-018-27521-y Hoadley, 2018, Cell-of-Origin patterns dominate the molecular article cell-of-Origin patterns dominate the molecular classification of 10,000 tumors from 33 types of Cancer, Cell, 173, 291, 10.1016/j.cell.2018.03.022 Yu, 2001, Specific protection against breast cancers by cyclin D1 ablation, Nature, 411, 1017, 10.1038/35082500 Odajima, 2016, Proteomic landscape of tissue-specific cyclin e functions in vivo, PLoS Genet., 12, 10.1371/journal.pgen.1006429 Arnason, 2013, Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc Min mice, Cancer Biol. Ther., 14, 672, 10.4161/cbt.25089 Park, 2007, The cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal Cancer, Am. J. Pathol., 171, 1509, 10.2353/ajpath.2007.070331 Kirley, 2005, The cables gene on chromosome 18Q regulates Colon Cancer, Cancer Biol. Ther., 4, 861, 10.4161/cbt.4.8.1894 Wu, 2001, Cables enhances Cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human Colon and squamous cancers, Cancer Res., 61, 7325 Shi, 2015, Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3, Oncogene, 34, 2538, 10.1038/onc.2014.171 Shi, 2015, Cables1 complex couples survival signaling to the cell death machinery, Cancer Res., 75, 147, 10.1158/0008-5472.CAN-14-0036 DeBernardo, 2005, Defining the extent of cables loss in endometrial cancer subtypes and its effectiveness as an inhibitor of cell proliferation in malignant endometrial cells in vitro and in vivo, Cancer Biol. Ther., 4, 103, 10.4161/cbt.4.1.1433 Zukerberg, 2004, Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial Cancer, Cancer Res., 64, 202, 10.1158/0008-5472.CAN-03-2833 Sato, 2002, ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl, Biochim. Biophys. Acta, 1574, 157, 10.1016/S0167-4781(01)00367-0 Matsuoka, 2003, ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways, Biochem. Biophys. Res. Commun., 312, 520, 10.1016/j.bbrc.2003.10.142 Zauberman, 1995, Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites, Oncogene, 10, 2361 Okamoto, 2002, Cyclin g recruits PP2A to dephosphorylate Mdm2, Mol. Cell, 9, 761, 10.1016/S1097-2765(02)00504-X Jensen, 2003, Reduced hepatic tumor incidence in cyclin G1-deficient mice, Hepatology, 37, 862, 10.1053/jhep.2003.50137 Skotzko, 1995, Retroviral vector-mediated inhibits proliferation gene transfer of antisense cyclin G1 (CYCG1) of human osteogenic sarcoma cells, Cancer Res., 55, 5493 Fornari, 2009, MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells, Cancer Res., 69, 5761, 10.1158/0008-5472.CAN-08-4797 Yan, 2016, MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression, J. Exp. Clin. Cancer Res., 35, 31, 10.1186/s13046-016-0307-1 Huang, 2018, The C/EBPbeta-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1, Cancer Lett., 421, 63, 10.1016/j.canlet.2018.02.020 Liu, 2013, Effects of expression of exogenous cyclin G1 on proliferation of human endometrial carcinoma cells, Chin. J. Physiol., 56, 83 Liu, 2012, The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cells, Reprod. Sci., 19, 1205, 10.1177/1933719112446073 Gao, 2018, Cyclin G2 suppresses Wnt/β -catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1, J. Exp. Clin. Cancer Res., 37, 317, 10.1186/s13046-018-0973-2 Zhang, 2018, CCNG2 overexpression mediated by AKT inhibits tumor cell proliferation in human astrocytoma cells, Front. Neurol., 9, 255, 10.3389/fneur.2018.00255 Qin, 2019, MiR-1290 targets CCNG2 to promote the metastasis of oral squamous cell carcinoma, Eur. Rev. Med. Pharmacol. Sci., 23, 10332 Xiao, 2015, MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma, Int. J. Oncol., 46, 161, 10.3892/ijo.2014.2704 Bernaudo, 2016, Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/beta-catenin signaling, Oncogene, 35, 4816, 10.1038/onc.2016.15 Kasukabe, 2008, A new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2, Cancer Sci., 99, 1693, 10.1111/j.1349-7006.2008.00867.x Le, 2007, Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells, Mol. Cancer Ther., 6, 2843, 10.1158/1535-7163.MCT-07-0109 Yin, 2016, MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2, Oncol. Rep., 36, 1111, 10.3892/or.2016.4876 Salem, 2019, miR-590-3p targets cyclin G2 and FOXO3 to promote ovarian Cancer cell proliferation, invasion, and spheroid formation, Int. J. Mol. Sci., 20, E1810, 10.3390/ijms20081810 Wang, 2016, MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction, Mol. Med. Rep., 13, 273, 10.3892/mmr.2015.4557 Fujimura, 2013, Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics, Neoplasia, 15, 1272, 10.1593/neo.131440 Gasa, 2017, A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer, Sci. Rep., 7, 10228, 10.1038/s41598-017-10770-8 Zhang, 2012, Development of transcriptomic biomarker signature in human saliva to detect lung cancer, Cell. Mol. Life Sci., 69, 3341, 10.1007/s00018-012-1027-0 Nagano, 2013, Cyclin I is involved in the regulation of cell cycle progression, Cell Cycle, 12, 2617, 10.4161/cc.25623 Liu, 2017, Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation, Sci. Rep., 7, 40979, 10.1038/srep40979 Feliciano, 2013, miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9, PLoS One, 8, 10.1371/journal.pone.0076247 Venturutti, 2016, MiR-16 mediates trastuzumab and lapatinib response in ErbB-2- positive breast and gastric cancer via its novel targets CCNJ and FUBP1, Oncogene, 35, 6189, 10.1038/onc.2016.151 Ting, 2013, Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D, J. Biol. Chem., 288, 1, 10.1074/jbc.M112.395947 Sun, 2015, Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer, Cell Death Dis., 6, e1907, 10.1038/cddis.2015.269 Zhang, 2019, Rs6265 polymorphism in brain-derived neurotrophic factor (Val/Val and Val/Met) promotes proliferation of bladder cancer cells by suppressing microRNA-205 and enhancing expression of cyclin J, J. Cell. Biochem., 120, 7297, 10.1002/jcb.28004 Villa, 2016, The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis, Nat. Commun., 7, 12652, 10.1038/ncomms12652 Funk, 2015, Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells, EMBO J., 34, 1078, 10.15252/embj.201490805 Li, 2018, Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis, Onco. Ther., 11, 7471, 10.2147/OTT.S176252 Roig, 2009, Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells, Cell Death Differ., 16, 230, 10.1038/cdd.2008.145 Sánchez-Botet, 2018, The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration, Sci. Rep., 8, 11797, 10.1038/s41598-018-30307-x Xu, 2010, Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation, Oncol. Res., 18, 359, 10.3727/096504010X12644422320582 Shi, 2018, Modulates the proliferation, invasion, and metastasis of hepatocellular carcinoma cells, Med. Sci. Monit., 24, 1642, 10.12659/MSM.906075 Yue, 2011, Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis, Clin. Lung Cancer, 12, 43, 10.3816/CLC.2011.n.006 Ma, 2019, Establishing a detection method for CCN: a potentially significant clinical investigative marker in NSCLC patients, Onco. Ther., 12, 921, 10.2147/OTT.S180507 Liu, 2016, Regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway, J. Immunother. Emphasis Tumor Immunol., 37, 10161 Yan, 2016, RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth, Oncol. Rep., 36, 2793, 10.3892/or.2016.5126 Hernández-Ortega, 2019, Phosphoregulation of oncogenic Protein Regulator of Cytokinesis (PRC1) by the atypical CDK16/CCNY complex, Exp. Mol. Med., 51, 44, 10.1038/s12276-019-0242-2 Wen, 2012, Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression, Hepatology, 55, 1787, 10.1002/hep.25596 Hasegawa, 2014, MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer, Br. J. Cancer, 111, 1572, 10.1038/bjc.2014.454 Si, 2019, Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell, J. Cell. Mol. Med., 23, 1095, 10.1111/jcmm.14010 Naito, 2013, Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of gammaH2AX following treatment with ionizing radiation, Cell Cycle, 12, 1773, 10.4161/cc.24878 Seo, 2006, Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1, Cell Death Differ., 13, 1475, 10.1038/sj.cdd.4401822 Russell, 2012, Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest, Oncogene, 31, 2450, 10.1038/onc.2011.431 Zimmermann, 2012, Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin, J. Biol, Chem., 287, 22838 Li, 2015, Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer, Eur. Rev. Med. Pharmacol. Sci., 19, 4533 Shi, 2017, Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J, BMC Cancer, 17, 138, 10.1186/s12885-017-3132-9 Sherr, 2016, Targeting CDK4 and CDK6: From Discovery to Therapy, Cancer Discov., 6, 353, 10.1158/2159-8290.CD-15-0894 O’Leary, 2016, Treating cancer with selective CDK4/6 inhibitors, Nat. Rev. Clin. Oncol., 13, 417, 10.1038/nrclinonc.2016.26 Ingham, 2019, Cell-cycle therapeutics come of age, J. Clin. Oncol., 35, 2949, 10.1200/JCO.2016.69.0032 Zheng, 2010, A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation, J. Biol. Chem., 285, 34202, 10.1074/jbc.M110.134643 Malumbres, 2014, Cyclin-dependent kinases, Genome Biol., 15, 122, 10.1186/gb4184 Lim, 2013, Cdks, cyclins and CKIs: roles beyond cell cycle regulation, Development, 140, 3079, 10.1242/dev.091744 Liu, 2010, Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements, ACS Chem. Biol., 5, 1169, 10.1021/cb1001262 Karthiga, 2015, Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/cyclin A complex using p27(KIP1)-derived peptidomimetic inhibitors, J. Chem. Biol., 8, 11, 10.1007/s12154-014-0124-y Canela, 2006, Identification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A, J. Biol. Chem., 281, 35942, 10.1074/jbc.M603511200 Peyressatre, 2015, Targeting cyclin-dependent kinases in human cancers: from small molecules to peptide inhibitors, Cancers (Basel), 7, 179, 10.3390/cancers7010179 Bennett, 2019, Therapeutic antisense oligonucleotides are coming of age, Annu. Rev. Med., 70, 307, 10.1146/annurev-med-041217-010829 Rinaldi, 2018, Antisense oligonucleotides: the next frontier for treatment of neurological disorders, Nat. Rev. Neurol., 14, 9, 10.1038/nrneurol.2017.148 Le, 2019, Antisense oligonucleotides targeting angiogenic factors as potential Cancer therapeutics, Mol. Ther. Nucleic Acid., 14, 142, 10.1016/j.omtn.2018.11.007 Egloff, 2006, Cyclin B1 and other cyclins as tumor antigens in Immunosurveillance and immunotherapy of Cancer, Cancer Res., 66, 6, 10.1158/0008-5472.CAN-05-3389 von Bergwelt-Baildon, 2011, The cyclins: a family of widely expressed tumor antigens?, Expert Rev. Vaccines, 10, 389, 10.1586/erv.10.170 Wang, 2009, Cyclin D1 as a universally-expressed mamtle cell lymphoma-associated tumor antigen for immunotherapy, Leukemia, 23, 1320, 10.1038/leu.2009.19 Vella, 2009, Immunity against cyclin B1 tumor antigen delays development of spontaneous cyclin B1-positive tumors in p53 (-/-) mice, Ann. N. Y. Acad. Sci., 1174, 68, 10.1111/j.1749-6632.2009.04941.x Gibb, 2018, Novel cyclin D1-based DC vaccine inhibits TNBC tumor growth, J. Immunol., 200, 10.4049/jimmunol.200.Supp.181.13 Chen, 2015, A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40, J. Hematol. Oncol., 8, 35, 10.1186/s13045-015-0131-7 Wang, 2019, Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes, Sci. Rep., 9, 253, 10.1038/s41598-018-36319-x Siegel, 2019, Cancer statistics, 2019, CA Cancer J. Clin., 69, 7, 10.3322/caac.21551 Moore, 2013, In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?, Nat. Rev. Cancer, 13, 201, 10.1038/nrc3468 Mathias, 2015, Tissue-based map of the human proteome, Science, 347