Attitudes toward taking medication among outpatients with schizophrenia: cross-national comparison between Tokyo and Beijing
Tóm tắt
The aim of this study was to compare attitudes toward medication and associated factors for patients with schizophrenia in Japan and China. Age-group matched samples were drawn from outpatients in Tokyo (N = 76) and Beijing (N = 76) according to the same inclusion/exclusion criteria. Psychotropic prescription and attitudes toward medication were measured using Drug Attitude Inventory-30 (DAI-30) and an original questionnaire regarding beliefs about psychiatric medication. Stepwise regression analysis of the DAI-30 data was performed for each group. Japanese subjects were prescribed significantly larger amounts of antipsychotics. Polypharmacy of antipsychotics and concurrent use of anticholinergics, anxiolytics, or hypnotics were more frequently found among subjects in Tokyo than among those in Beijing. However, subjects in Tokyo and Beijing had similar subjective responses to medication, subjective evaluation of side-effects, and complaints about overuse of psychotropics. Subjects in Tokyo complained less about physician’s over-reliance on medication and were less concerned about medication cost than those in Beijing. In Tokyo, longer duration of illness and lower subjective distress caused by side effects predicted a more positive subjective response, while female gender, younger age, and lower Brief Psychiatric Rating Scale score were independently correlated with a better subjective response in Beijing. Subjective acceptance of multiple medications is greater for patients in Japan than those in China. Determinants of subjective response to medication varied between Japan and China.
Tài liệu tham khảo
Bitter I, Chou JC, Ungvari GS, Tang WK, Xiang Z, Iwanami A, et al. Prescribing for inpatients with schizophrenia: an international multi-center comparative study. Pharmacopsychiatry. 2003;36:143–9.
Chong MY, Tan CH, Fujii S, Yang SY, Ungvari GS, Si T, et al. Antipsychotic drug prescription for schizophrenia in East Asia: rationale for change. Psychiatry Clin Neurosci. 2004;58:61–7.
Ito H, Koyama A, Higuchi T. Polypharmacy and excessive dosing: psychiatrists’ perceptions of antipsychotic drug prescription. Br J Psychiatry. 2005;187:243–7.
Chue P. The relationship between patient satisfaction and treatment outcome in schizophrenia. J Psychopharmacol. 2006;20:38–56.
Hellewell JS. Patients’ subjective experiences of antipsychotics: clinical relevance. CNS Drugs. 2002;16:457–71.
Awad AG, Hogan TP, Voruganti LN, Heslegrave RJ. Patients’ subjective experiences on antipsychotic medications: implications for outcome and quality of life. Int Clin Psychopharmacol. 1995;10:123–32.
Hogan TP, Awad AG. Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures. Psychol Med. 1992;22:347–52.
Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002;63:892–909.
Awad AG, Voruganti LN, Heslegrave RJ, Hogan TP. Assessment of the patient’s subjective experience in acute neuroleptic treatment: implications for compliance and outcome. Int Clin Psychopharmacol. 1996;11:55–9.
Inagaki A, Inada T, Fujii Y, Yagi G. Equivalent doses of psychotropics. Tokyo: Seiwa Shoten; 1999.
Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 1962;10:799–812.
Woerner MG, Mannuzza S, Kane JM. Anchoring the BPRS: an aid to improved reliability. Psychopharmacol Bull. 1988;24:112–7.
Hogan TP, Awad AG, Eastwood R. A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity. Psychol Med. 1983;13:177–83.
Cheng HL, Yu YW. Validation of the Chinese version of “the Drug Attitude Inventory”. Kaohsiung J Med Sci. 1997;13:370–7.
Miyata R, Fujii Y, Inagaki A, Yagi G. Pharmacotherapy for patients with schizophrenia and quality of life (1) Japanese version of Drug Attitude Inventory. Seishin Shinkeigaku Zasshi. 1996;98:1045–6. (article in Japanese).
Smith BP. Acquiescent response bias as an aspect of cultural communication bias. J Cross Cult Psychol. 2004;35:50–61.
Fischer R. Standardization to account for cross-cultural response bias: a classification of score adjustment procedures and review of research in JCCP. J Cross Cult Psychol. 2004;35:263–82.
Ritsner M, Perelroyzen G, Ilan H, Gibel A. Subjective response to antipsychotics of schizophrenia patients treated in routine clinical practice: a naturalistic comparative study. J Clin Psychopharmacol. 2004;24:245–54.
Voruganti L, Cortese L, Oyewumi L, Cernovsky Z, Zirul S, Awad A. Comparative evaluation of conventional and novel antipsychotic drugs with reference to their subjective tolerability, side-effect profile and impact on quality of life. Schizophr Res. 2000;43:135–45.
Sim K, Su A, Leong JY, Yip K, Chong MY, Fujii S, et al. High dose antipsychotic use in schizophrenia: findings of the REAP (research on east Asia psychotropic prescriptions) study. Pharmacopsychiatry. 2004;37:175–9.
Kane JM. Dose selection and comparator drugs in schizophrenia research. J Clin Psychiatry. 2001;62(Suppl 9):29–32.
Lee S. The prevalence and nature of lithium noncompliance among Chinese psychiatric patients in Hong Kong. J Nerv Ment Dis. 1993;181:618–25.
Sekimoto M, Asai A, Ohnishi M, Nishigaki E, Fukui T, Shimbo T, et al. Patients’ preferences for involvement in treatment decision making in Japan. BMC Fam Pract. 2004;5:1.
Slingsby BT. Decision-making models in Japanese psychiatry: transition from passive to active patterns. Soc Sci Med. 2004;59:83–91.
Iihara N, Tsukamoto T, Morita S, Miyoshi C, Takabatake K, Kurosaki Y. Beliefs of chronically ill Japanese patients that lead to intentional non-adherence to medication. J Clin Pharm Ther. 2004;29:417–24.
Phillips MR, Lu SH, Wang RW. Economic reforms and the acute inpatient care of patients with schizophrenia: the Chinese experience. Am J Psychiatry. 1997;154:1228–34.
Yip KS. An historical review of the mental health services in the People’s Republic of China. Int J Soc Psychiatry. 2005;51:106–18.
Hesketh T, Zhu WX. Health in China. Traditional Chinese medicine: one country, two systems. BMJ. 1997;315:115–7.
Adewuya AO, Ola BA, Mosaku SK, Fatoye FO, Eegunranti AB. Attitude towards antipsychotics among out-patients with schizophrenia in Nigeria. Acta Psychiatr Scand. 2006;113:207–11.
Freudenreich O, Cather C, Evins AE, Henderson DC, Goff DC. Attitudes of schizophrenia outpatients toward psychiatric medications: relationship to clinical variables and insight. J Clin Psychiatry. 2004;65:1372–6.
Hofer A, Kemmler G, Eder U, Honeder M, Hummer M, Fleischhacker WW. Attitudes toward antipsychotics among outpatient clinic attendees with schizophrenia. J Clin Psychiatry. 2002;63:49–53.
Gervin M, Browne S, Garavan J, Roe M, Larkin C, O’Callaghan E. Dysphoric subjective response to neuroleptics in schizophrenia: relationship to extrapyramidal side effects and symptomatology. Eur Psychiatry. 1999;14:405–9.
Cabeza IG, Amador MS, Lopez CA, Gonzalez de Chavez M. Subjective response to antipsychotics in schizophrenic patients: clinical implications and related factors. Schizophr Res. 2000;41:349–55.
Sibitz I, Katschnig H, Goessler R, Unger A, Amering M. Pharmacophilia and pharmacophobia: determinants of patients’ attitudes towards antipsychotic medication. Pharmacopsychiatry. 2005;38:107–12.
Chan MF, Mok E, Wong YS, Tong TF, Day MC, Tang CK, et al. Attitudes of Hong Kong Chinese to traditional Chinese medicine and Western medicine: survey and cluster analysis. Complement Ther Med. 2003;11:103–9.