Atrofia cerebral en pacientes con síndrome desmielinizante aislado

Tintore, 2006, Baseline MRI predicts future attacks and disability in clinically isolated syndromes, Neurology, 67, 968, 10.1212/01.wnl.0000237354.10144.ec Fernández-Fernández, 2002, Clinical features of relapsing remitting-multiple sclerosis, Prognostic factors. Rev Neurol, 35, 1067 Ferguson, 1997, Axonal damage in acute multiple sclerosis lesions, Brain, 120, 393, 10.1093/brain/120.3.393 Pascual-Lozano, 2007, Total brain T2-hyperintense lesion-volume and the axonal damage in the normal-appearing white matter of brainstem in early lapsing-remitting multiple sclerosis, Rev Neurol, 45, 468 Trapp, 1998, Axonal transection in the lesions of multiple sclerosis, N Engl J Med, 338, 278, 10.1056/NEJM199801293380502 Arnold, 1990, Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease, Magn Reson Med, 14, 154, 10.1002/mrm.1910140115 De Stefano, 1995, Chemical pathology of acute demyelinating lesions and its correlation with disability, Ann Neurol, 38, 901, 10.1002/ana.410380610 Narayana, 1998, Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis, Ann Neurol, 43, 56, 10.1002/ana.410430112 Pato-Pato, 2003, Cerebral atrophy in multiple sclerosis patients treated periodically with boluses of methylprednisolone, Rev Neurol, 37, 501 Rudick, 1999, Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group, Neurology, 53, 1698, 10.1212/WNL.53.8.1698 Dalton, 2004, Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes, Brain, 127, 1101, 10.1093/brain/awh126 Smith, 2002, Accurate, robust, and automated longitudinal and cross-sectional brain change analysis, Neuroimage, 17, 479, 10.1006/nimg.2002.1040 Zhang, 2001, Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm, IEEE Trans Med Imaging, 20, 45, 10.1109/42.906424 De Stefano, 2003, Evidence of early cortical atrophy in MS: relevance to white matter changes and disability, Neurology, 60, 1157, 10.1212/01.WNL.0000055926.69643.03 Kidd, 1999, Cortical lesions in multiple sclerosis, Brain, 122, 17, 10.1093/brain/122.1.17 Peterson, 2001, Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions, Ann Neurol, 50, 389, 10.1002/ana.1123 Evangelou, 2001, Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis, Brain, 124, 1813, 10.1093/brain/124.9.1813