Atherosclerosis: Recent developments

Abdellatif, 2021, NAD(+) metabolism in cardiac health, aging, and disease, Circulation, 144, 1795, 10.1161/CIRCULATIONAHA.121.056589 Aherrahrou, 2020, Genetic regulation of atherosclerosis-relevant phenotypes in human vascular smooth muscle cells, Circ. Res., 127, 1552, 10.1161/CIRCRESAHA.120.317415 Ahmad, 2021, Cysteamine decreases low-density lipoprotein oxidation, causes regression of atherosclerosis, and improves liver and muscle function in low-density lipoprotein receptor-deficient mice, J. Am. Heart Assoc., 10, e017524, 10.1161/JAHA.120.017524 Alencar, 2020, Stem cell pluripotency genes Klf4 and Oct4 regulate complex SMC phenotypic changes critical in late-stage atherosclerotic lesion pathogenesis, Circulation, 142, 2045, 10.1161/CIRCULATIONAHA.120.046672 Al-Mashhadi, 2021, Local pressure drives low-density lipoprotein accumulation and coronary atherosclerosis in hypertensive minipigs, J. Am. Coll. Cardiol., 77, 575, 10.1016/j.jacc.2020.11.059 AlSiraj, 2019, XX sex chromosome complement promotes atherosclerosis in mice, Nat. Commun., 10, 2631, 10.1038/s41467-019-10462-z Amor, 2020, Senolytic CAR T cells reverse senescence-associated pathologies, Nature, 583, 127, 10.1038/s41586-020-2403-9 Aragam, 2020, Polygenic scores to assess atherosclerotic cardiovascular disease risk: clinical perspectives and basic implications, Circ. Res., 126, 1159, 10.1161/CIRCRESAHA.120.315928 Bäck, 2019, Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities, Nat. Rev. Cardiol., 16, 389 Backman, 2021, Exome sequencing and analysis of 454,787 UK Biobank participants, Nature, 599, 628, 10.1038/s41586-021-04103-z Basatemur, 2019, Vascular smooth muscle cells in atherosclerosis, Nat. Rev. Cardiol., 16, 727, 10.1038/s41569-019-0227-9 Benjamin, 2018, Heart disease and stroke statistics-2018 update: a report from the American Heart Association, Circulation, 137, e67, 10.1161/CIR.0000000000000558 Bhatnagar, 2017, Environmental determinants of cardiovascular disease, Circ. Res., 121, 162, 10.1161/CIRCRESAHA.117.306458 Bick, 2020, Inherited causes of clonal haematopoiesis in 97,691 whole genomes, Nature, 586, 763, 10.1038/s41586-020-2819-2 Biddinger, 2022, Association of habitual alcohol intake with risk of cardiovascular disease, JAMA Netw Open, 5, e223849, 10.1001/jamanetworkopen.2022.3849 Björkegren, 2015, Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders, J. Am. Coll. Cardiol., 65, 830, 10.1016/j.jacc.2014.12.033 Borén, 2016, The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity, Curr. Opin. Lipidol., 27, 473, 10.1097/MOL.0000000000000330 Cabrera, 2019, Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated, Hum. Mol. Genet., 28, R151, 10.1093/hmg/ddz197 Chen, 2022, Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis, Nat. Rev. Cardiol., 19, 228, 10.1038/s41569-021-00629-x Childs, 2021, Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis, Nat Aging, 1, 698, 10.1038/s43587-021-00089-5 Cochain, 2018, Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis, Circ. Res., 122, 1661, 10.1161/CIRCRESAHA.117.312509 Covarrubias, 2021, NAD(+) metabolism and its roles in cellular processes during ageing, Nat. Rev. Mol. Cell Biol., 22, 119, 10.1038/s41580-020-00313-x Daugherty, 2017, Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association, Arterioscler. Thromb. Vasc. Biol., 37, e131, 10.1161/ATV.0000000000000062 Depuydt, 2020, Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics, Circ. Res., 127, 1437, 10.1161/CIRCRESAHA.120.316770 Domínguez, 2019, Association of sleep duration and quality with subclinical atherosclerosis, J. Am. Coll. Cardiol., 73, 134, 10.1016/j.jacc.2018.10.060 Doran, 2020, Efferocytosis in health and disease, Nat. Rev. Immunol., 20, 254, 10.1038/s41577-019-0240-6 Dou, 2021, Oxidized phospholipids promote NETosis and arterial thrombosis in LNK(SH2B3) deficiency, Circulation, 144, 1940, 10.1161/CIRCULATIONAHA.121.056414 Eales, 2019, Human Y chromosome exerts pleiotropic effects on susceptibility to atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 39, 2386, 10.1161/ATVBAHA.119.312405 Edgar, 2021, Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis, Circulation, 144, 961, 10.1161/CIRCULATIONAHA.120.046464 Erdmann, 2018, A decade of genome-wide association studies for coronary artery disease: the challenges ahead, Cardiovasc. Res., 114, 1241 Fernandez, 2019, Single-cell immune landscape of human atherosclerotic plaques, Nat. Med., 25, 1576, 10.1038/s41591-019-0590-4 Fidler, 2021, The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis, Nature, 592, 296, 10.1038/s41586-021-03341-5 Franzén, 2016, Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases, Science, 353, 827, 10.1126/science.aad6970 Frodermann, 2019, Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells, Nat. Med., 25, 1761, 10.1038/s41591-019-0633-x Gerlach, 2021, Efferocytosis induces macrophage proliferation to help resolve tissue injury, Cell Metab., 33, 2445, 10.1016/j.cmet.2021.10.015 Gimbrone, 2016, Endothelial cell dysfunction and the pathobiology of atherosclerosis, Circ. Res., 118, 620, 10.1161/CIRCRESAHA.115.306301 Giri, 2019, Trans-ethnic association study of blood pressure determinants in over 750,000 individuals, Nat. Genet., 51, 51, 10.1038/s41588-018-0303-9 Goettsch, 2016, A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification, Atherosclerosis, 251, 109, 10.1016/j.atherosclerosis.2016.06.011 Graham, 2021, The power of genetic diversity in genome-wide association studies of lipids, Nature, 600, 675, 10.1038/s41586-021-04064-3 Grootaert, 2021, SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis, Circ. Res., 128, 474, 10.1161/CIRCRESAHA.120.318353 Gu, 2019, AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate, Science, 363, 1085, 10.1126/science.aav1749 Gupta, 2020, Novel emerging therapies in atherosclerosis targeting lipid metabolism, Expert Opin. Investig. Drugs, 29, 611, 10.1080/13543784.2020.1764937 Gupta, 2021, Electronic and tobacco cigarettes alter polyunsaturated fatty acids and oxidative biomarkers, Circ. Res., 129, 514, 10.1161/CIRCRESAHA.120.317828 Han, 2021, Enterically derived high-density lipoprotein restrains liver injury through the portal vein, Science, 373, eabe6729, 10.1126/science.abe6729 Hartman, 2021, Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching, Circulation, 143, 713, 10.1161/CIRCULATIONAHA.120.051231 He, 2018, Macrophages release plasma membrane-derived particles rich in accessible cholesterol, Proc. Natl. Acad. Sci. USA, 115, E8499, 10.1073/pnas.1810724115 He, 2019, Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease, Nature, 566, 115, 10.1038/s41586-018-0849-9 Heyde, 2021, Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis, Cell, 184, 1348, 10.1016/j.cell.2021.01.049 Hilser, 2021, Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection, J. Lipid Res., 62, 100061, 10.1016/j.jlr.2021.100061 Hindy, 2020, Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease, Arterioscler. Thromb. Vasc. Biol., 40, 2738, 10.1161/ATVBAHA.120.314856 Jaiswal, 2017, Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease, N. Engl. J. Med., 377, 111, 10.1056/NEJMoa1701719 Jie, 2017, The gut microbiome in atherosclerotic cardiovascular disease, Nat. Commun., 8, 845, 10.1038/s41467-017-00900-1 Kasahara, 2018, Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model, Nat. Microbiol., 3, 1461, 10.1038/s41564-018-0272-x Kim-Hellmuth, 2020, Cell type-specific genetic regulation of gene expression across human tissues, Science, 369, eaaz8528, 10.1126/science.aaz8528 Koplev, 2022, A mechanistic framework for cardiometabolic and coronary artery diseases, Nat. Cardiovasc. Res., 1, 85, 10.1038/s44161-021-00009-1 Kotla, 2019, Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein, JCI Insight, 4, e124867, 10.1172/jci.insight.124867 Koyama, 2020, Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease, Nat. Genet., 52, 1169, 10.1038/s41588-020-0705-3 Libby, 2021, The changing landscape of atherosclerosis, Nature, 592, 524, 10.1038/s41586-021-03392-8 Liu, 2017, Exome-wide association study of plasma lipids in >300,000 individuals, Nat. Genet., 49, 1758, 10.1038/ng.3977 Luo, 2021, Plaque erosion: a distinctive pathological mechanism of acute coronary syndrome, Front. Cardiovasc. Med., 8, 711453, 10.3389/fcvm.2021.711453 Mahajan, 2018, Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, Nat. Genet., 50, 1505, 10.1038/s41588-018-0241-6 Man, 2020, Sex as a biological variable in atherosclerosis, Circ. Res., 126, 1297, 10.1161/CIRCRESAHA.120.315930 McAlpine, 2019, Sleep modulates haematopoiesis and protects against atherosclerosis, Nature, 566, 383, 10.1038/s41586-019-0948-2 Mori, 2018, Coronary artery calcification and its progression: what does it really mean?, JACC Cardiovasc. Imaging, 11, 127, 10.1016/j.jcmg.2017.10.012 Mukherjee, 2022, Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation, J. Lipid Res., 63, 100153, 10.1016/j.jlr.2021.100153 Musunuru, 2021, In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates, Nature, 593, 429, 10.1038/s41586-021-03534-y Newman, 2021, Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRbeta and bioenergetic mechanisms, Nat. Metab., 3, 166, 10.1038/s42255-020-00338-8 Nikpay, 2019, Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes, Cardiovasc. Res., 115, 1629, 10.1093/cvr/cvz030 Noonan, 2022, The tandem stenosis mouse model: towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture, Br. J. Pharmacol., 179, 979, 10.1111/bph.15356 Örd, 2021, Single-cell epigenomics and functional fine-mapping of atherosclerosis GWAS loci, Circ. Res., 129, 240, 10.1161/CIRCRESAHA.121.318971 Orecchioni, 2022, Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production, Science, 375, 214, 10.1126/science.abg3067 Pan, 2020, Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human, Circulation, 142, 2060, 10.1161/CIRCULATIONAHA.120.048378 Pasta, 2020, PCSK9 inhibitors for treating hypercholesterolemia, Expert Opin. Pharmacother., 21, 353, 10.1080/14656566.2019.1702970 Pierce, 2020, Long noncoding RNAs in atherosclerosis and vascular injury: pathobiology, biomarkers, and targets for therapy, Arterioscler. Thromb. Vasc. Biol., 40, 2002, 10.1161/ATVBAHA.120.314222 Poznyak, 2020, The diabetes mellitus-atherosclerosis connection: the role of lipid and glucose metabolism and chronic inflammation, Int. J. Mol. Sci., 21, 1835, 10.3390/ijms21051835 Proto, 2018, Regulatory T cells promote macrophage efferocytosis during inflammation resolution, Immunity, 49, 666, 10.1016/j.immuni.2018.07.015 Que, 2018, Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice, Nature, 558, 301, 10.1038/s41586-018-0198-8 Robbins, 2013, Local proliferation dominates lesional macrophage accumulation in atherosclerosis, Nat. Med., 19, 1166, 10.1038/nm.3258 Roberts, 2018, Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential, Nat. Med., 24, 1407, 10.1038/s41591-018-0128-1 Roy, 2022, How the immune system shapes atherosclerosis: roles of innate and adaptive immunity, Nat. Rev. Immunol. ahead of print, 22, 251, 10.1038/s41577-021-00584-1 Sage, 2019, The role of B cells in atherosclerosis, Nat. Rev. Cardiol., 16, 180, 10.1038/s41569-018-0106-9 Sanna, 2022, Challenges and future directions for studying effects of host genetics on the gut microbiome, Nat. Genet., 54, 100, 10.1038/s41588-021-00983-z Schloss, 2020, Modifiable cardiovascular risk, hematopoiesis, and innate immunity, Circ. Res., 126, 1242, 10.1161/CIRCRESAHA.120.315936 Seldin, 2019, Systems genetics applications in metabolism research, Nat. Metab., 1, 1038, 10.1038/s42255-019-0132-x Souilhol, 2020, Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes, Nat. Rev. Cardiol., 17, 52, 10.1038/s41569-019-0239-5 Stolze, 2020, Systems genetics in human endothelial cells identifies non-coding variants modifying enhancers, expression, and complex disease traits, Am. J. Hum. Genet., 106, 748, 10.1016/j.ajhg.2020.04.008 Tabas, 2020, Intracellular and intercellular aspects of macrophage immunometabolism in atherosclerosis, Circ. Res., 126, 1209, 10.1161/CIRCRESAHA.119.315939 Tang, 2019, Intestinal microbiota in cardiovascular health and disease: JACC State-of-the-art review, J. Am. Coll. Cardiol., 73, 2089, 10.1016/j.jacc.2019.03.024 Thomas, 2021, Lipid and metabolic syndrome traits in coronary artery disease: a Mendelian randomization study, J. Lipid Res., 62, 100044, 10.1194/jlr.P120001000 Tsimikas, 2020, Statin therapy increases lipoprotein(a) levels, Eur. Heart J., 41, 2275, 10.1093/eurheartj/ehz310 Tyrrell, 2021, Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6, Nat. Rev. Cardiol., 18, 58, 10.1038/s41569-020-0431-7 von Scheidt, 2017, Applications and limitations of mouse models for understanding human atherosclerosis, Cell Metab., 25, 248, 10.1016/j.cmet.2016.11.001 Wang, 2021, Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells, Cardiovasc. Res., 10.1093/cvr/cvab347 Williams, 2019, Plasma protein patterns as comprehensive indicators of health, Nat. Med., 25, 1851, 10.1038/s41591-019-0665-2 Winkels, 2018, Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry, Circ. Res., 122, 1675, 10.1161/CIRCRESAHA.117.312513 Wirka, 2019, Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis, Nat. Med., 25, 1280, 10.1038/s41591-019-0512-5 Xie, 2022, Long-term cardiovascular outcomes of COVID-19, Nat. Med., 28, 583, 10.1038/s41591-022-01689-3 Yin, 2019, Diesel exhaust induces mitochondrial dysfunction, hyperlipidemia, and liver steatosis, Arterioscler. Thromb. Vasc. Biol., 39, 1776, 10.1161/ATVBAHA.119.312736 Zhang, 2018, Endothelial transcytosis of lipoproteins in atherosclerosis, Front. Cardiovasc. Med., 5, 130, 10.3389/fcvm.2018.00130 Zhao, 2021, A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease, eLife, 10, e58361, 10.7554/eLife.58361