Asymptotic Formulas for Extreme Statistics of Escape Times in 1, 2 and 3-Dimensions

Journal of Nonlinear Science - Tập 29 - Trang 461-499 - 2018
K. Basnayake1, Z. Schuss2, D. Holcman1
1Applied Mathematics and Computational Biology, Ecole Normale Supérieure, Paris, France
2Department of Applied Mathematics, Tel-Aviv University, Tel Aviv, Israel

Tóm tắt

The first of N identical independently distributed (i.i.d.) Brownian trajectories that arrives to a small target sets the time scale of activation, which in general is much faster than the arrival to the target of a single trajectory only. Analytical asymptotic expressions for the minimal time is notoriously difficult to compute in general geometries. We derive here asymptotic laws for the probability density function of the first and second arrival times of a large number N of i.i.d. Brownian trajectories to a small target in 1, 2 and 3-dimensions and study their range of validity by stochastic simulations. The results are applied to activation of biochemical pathways in cellular biology.

Tài liệu tham khảo

Abramowitz, M., Stegun, I.A.: Handbook of Mathematical Functions: With Formulas, Graphs, and Mathematical Tables, vol. 55. Courier Corporation, North Chelmsford (1964) Chen, W., Ward, M.J.: The stability and dynamics of localized spot patterns in the two-dimensional Gray–Scott model. SIAM J. Appl. Dyn. Syst. 10(2), 582–666 (2011) Chou, T., Dorsogna, M.: First passage problems in biology. First-Passage Phenom. Their Appl. 35, 306 (2014) Colin de Verdière, Y.: Spectre du laplacien et longueurs des géodésiques périodiques i. Compos. Math. 27(1), 83–106 (1973) Freche, D., Pannasch, U., Rouach, N., Holcman, D.: Synapse geometry and receptor dynamics modulate synaptic strength. PLoS ONE 6(10), e25122 (2011) Gross, O.P., Pugh, E.N., Burns, M.E.: Calcium feedback to cgmp synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron 76(2), 370–382 (2012) Guerrier, C., Korkotian, E., Holcman, D.: Calcium dynamics in neuronal microdomains: Modeling, stochastic simulations, and data analysis. In: Jaeger, D., Jung, R. (eds.) Encyclopedia of Computational Neuroscience, pp. 486–516. Springer, New York, NY (2015) Hille, B.: Ion Channels of Excitable Membranes, vol. 507. Sinauer, Sunderland (2001) Holcman, D., Schuss, Z.: Escape through a small opening: receptor trafficking in a synaptic membrane. J. Stat. Phys. 117(5), 975–1014 (2004) Holcman, D., Schuss, Z.: Diffusion escape through a cluster of small absorbing windows. J. Phys. A Math. Theor. 41(15), 155001 (2008) Holcman, D., Schuss, Z.: The narrow escape problem. SIAM Rev. 56(2), 213–257 (2014) Holcman, D., Schuss, Z.: Stochastic Narrow Escape in Molecular and Cellular Biology. Analysis and Applications. Springer, New York (2015) Holcman, D., Schuss, Z., Korkotian, E.: Calcium dynamics in dendritic spines and spine motility. Biophys. J. 87(1), 81–91 (2004) Holcman, D., Marchewka, A., Schuss, Z.: Survival probability of diffusion with trapping in cellular neurobiology. Phys. Rev. E 72(3), 031910 (2005) Katz, B., Voolstra, O., Tzadok, H., Yasin, B., Rhodes-Modrov, E., Bartels, J.-P., Strauch, L., Huber, A., Minke, B.: The latency of the light response is modulated by the phosphorylation state of drosophila trp at a specific site. Channels 37, 1–8 (2017) Krapivsky, P., Majumdar, S.N., Rosso, A.: Maximum of n independent brownian walkers till the first exit from the half-space. J. Phys. A Math. Theor. 43(31), 315001 (2010) Majumdar, S.N., Pal, A.: Extreme value statistics of correlated random variables. (2014). arXiv preprint arXiv:1406.6768 Redner, S., Meerson, B.: First invader dynamics in diffusion-controlled absorption. J. Stat. Mech. Theory Exp. 2014(6), P06019 (2014) Reingruber, J., Pahlberg, J., Woodruff, M.L., Sampath, A.P., Fain, G.L., Holcman, D.: Detection of single photons by toad and mouse rods. Proc. Natl. Acad. Sci. 110(48), 19378–19383 (2013) Schehr, G.: Extremes of n vicious walkers for large n: application to the directed polymer and kpz interfaces. J. Stat. Phys. 149(3), 385–410 (2012) Schuss, Z.: Theory and Applications of Stochastic Processes: An Analytical Approach, vol. 170. Springer, New York (2009) Schuss, Z.: Diffusion and Stochastic Processes: An Analytical Approach. Springer Series on Applied Mathematical Sciences, vol. 170. Springer, New York (2010) Schuss, Z.: Brownian Dynamics at Boundaries and Interfaces. Springer, New York (2015) Schuss, Z., Spivak, A.: On recovering the shape of a domain from the trace of the heat kernel. SIAM J. Appl. Math. 66(1), 339–360 (2005) Schuss, Z., Singer, A., Holcman, D.: The narrow escape problem for diffusion in cellular microdomains. Proc. Natl. Acad. Sci. 104(41), 16098–16103 (2007) Singer, A., Schuss, Z., Holcman, D.: Narrow escape, part iii: non-smooth domains and Riemann surfaces. J. Stat. Phys. 122(3), 491–509 (2006) Sokolov, I.M., Metzler, R., Pant, K., Williams, M.C.: First passage time of n excluded-volume particles on a line. Phys. Rev. E 72(4), 041102 (2005) Taflia, A., Holcman, D.: Estimating the synaptic current in a multiconductance ampa receptor model. Biophys. J. 101(4), 781–792 (2011) Volfovsky, N., Parnas, H., Segal, M., Korkotian, E.: Geometry of dendritic spines affects calcium dynamics in hippocampal neurons: theory and experiments. J. Neurophysiol. 82(1), 450–462 (1999) Yuste, S.B., Lindenberg, K.: Order statistics for first passage times in one-dimensional diffusion processes. J. Stat. Phys. 85(3), 501–512 (1996) Yuste, S.B., Acedo, L., Lindenberg, K.: Order statistics for d-dimensional diffusion processes. Phys. Rev. E 64(5), 052102 (2001) Zilman, A., Bel, G.: Crowding effects in non-equilibrium transport through nano-channels. J. Phys. Condens. Matter 22(45), 454130 (2010)