Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019 (COVID-19): a population-based surveillance study

National Science Review - Tập 7 Số 10 - Trang 1527-1539 - 2020
Xueying Zheng1,2, Sihui Luo1,2, Yong Sun3, Mingfeng Han4, Jian Liu5, Liangye Sun6, Liangming Zhang7, Ping Ling1,2, Yu Ding1,2, Katherine A. Fitzgerald8,2, Zhirong Liu3, Jianping Weng1,2
1Clinical Research Hospital (Hefei) of Chinese Academy of Sciences, Hefei 230001, China
2The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230001, China
3Key Laboratory for Medical and Health of the 13th Five-Year Plan, Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China
4Fuyang No.2 People's Hospital, Fuyang 236015, China
5Anqing Hospital Affiliated to Anhui Medical University (Anqing Municipal Hospital), Anqing 246003, China
6Lu'an People's Hospital, Lu'an 237005, China
7Department of Infectious Disease, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230001, China
8Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230001, China

Tóm tắt

Abstract In this population-based study, we identified 307 confirmed COVID-19 cases from massive surveillance, including 129 551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients. Among them, 17 patients were asymptomatic at initial clinical assessment. These asymptomatic patients on admission accounted for a small proportion of all patients (5.54%) with relatively weak transmissibility, and the detection rate was 0.35 per 100 close contacts. Moreover, the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days (interquartile range 2.0 to 11.0 days), with 14 patients (4.56%) having re-detectable viral RNA after discharge. Overall, our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients. Also, the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended.

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National Science Review

Tập 7 Số 10

1527-1539

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