Astrocytes in Alzheimer's Disease
Tóm tắt
Từ khóa
Tài liệu tham khảo
Case, 2007, Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system, Cell Calcium, 42, 345, 10.1016/j.ceca.2007.05.001
Durell, 2001, A putative prokaryote voltage-gated Ca2+ channel with only one 6TM motif per subunit, Biochem Biophys Res Commun, 281, 741, 10.1006/bbrc.2001.4408
Matsushita, 1989, Calcium channels in bacteria, Ann N Y Acad Sci, 560, 426, 10.1111/j.1749-6632.1989.tb24127.x
Shemarova, 2005, Evolution of mechanisms of calcium signaling: the role of calcium ions in signal transduction in prokaryotes, Zh Evol Biokhim Fiziol, 41, 12
Tisa, 2000, Effects of organic antagonists of Ca2+, Na+, and K+ on chemotaxis and motility of Escherichia coli, J Bacteriol, 182, 4856, 10.1128/JB.182.17.4856-4861.2000
Eckert, 1979, Ionic mechanisms of excitation in Paramecium, Annu Rev Biophys Bioeng, 8, 353, 10.1146/annurev.bb.08.060179.002033
Franciolini, 1989, Evolution of ionic channels of biological membranes, Mol Biol Evol, 6, 503
Koishi, 2004, A superfamily of voltage-gated sodium channels in bacteria, J Biol Chem, 279, 9532, 10.1074/jbc.M313100200
Shemarova, 2005, Evolution of Ca2+ signaling mechanisms, Zh Evol Biokhim Fiziol, 41, 303
Ladenburger, 2009, Novel types of Ca2+ release channels participate in the secretory cycle of Paramecium cells, Mol Cell Biol, 29, 3605, 10.1128/MCB.01592-08
Matt, 1980, Genetic dissection of the final exocytosis steps in Paramecium tetraurelia cells: trigger analyses, J Cell Sci, 46, 41, 10.1242/jcs.46.1.41
Plattner, 1980, Genetic dissection of the final exocytosis steps in Paramecium tetraurelia cells: cytochemical determination of Ca2+-ATPase activity over performed exocytosis sites, J Cell Sci, 46, 17, 10.1242/jcs.46.1.17
Burnstock, 2009, Evolutionary origins of the purinergic signalling system, Acta Physiol (Oxf), 195, 415, 10.1111/j.1748-1716.2009.01957.x
Sakaguchi, 1996, Structure, development, and maintenance of the nerve net of the body column in Hydra, J Comp Neurol, 373, 41, 10.1002/(SICI)1096-9861(19960909)373:1<41::AID-CNE4>3.0.CO;2-D
Bacaj, 2008, Glia are essential for sensory organ function in C. elegans, Science, 322, 744, 10.1126/science.1163074
Verkhratsky, 2007
Oberheim, 2009, Uniquely hominid features of adult human astrocytes, J Neurosci, 29, 3276, 10.1523/JNEUROSCI.4707-08.2009
Oberheim, 2006, Astrocytic complexity distinguishes the human brain, Trends Neurosci, 29, 547, 10.1016/j.tins.2006.08.004
Bushong, 2004, Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development, Int J Dev Neurosci, 22, 73, 10.1016/j.ijdevneu.2003.12.008
Bushong, 2002, Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains, J Neurosci, 22, 183, 10.1523/JNEUROSCI.22-01-00183.2002
Nedergaard, 2003, New roles for astrocytes: redefining the functional architecture of the brain, Trends Neurosci, 26, 523, 10.1016/j.tins.2003.08.008
Iadecola, 2007, Glial regulation of the cerebral microvasculature, Nat Neurosci, 10, 1369, 10.1038/nn2003
Mulligan, 2004, Calcium transients in astrocyte endfeet cause cerebrovascular constrictions, Nature, 431, 195, 10.1038/nature02827
Takano, 2006, Astrocyte-mediated control of cerebral blood flow, Nat Neurosci, 9, 260, 10.1038/nn1623
Zonta, 2003, Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation, Nat Neurosci, 6, 43, 10.1038/nn980
Magistretti, 2006, Neuron-glia metabolic coupling and plasticity, J Exp Biol, 209, 2304, 10.1242/jeb.02208
Magistretti, 2009, Role of glutamate in neuron-glia metabolic coupling, Am J Clin Nutr, 90, 875S, 10.3945/ajcn.2009.27462CC
Kofuji, 2004, Potassium buffering in the central nervous system, Neuroscience, 129, 1045, 10.1016/j.neuroscience.2004.06.008
Newman, 1984, Control of extracellular potassium levels by retinal glial cell K+ siphoning, Science, 225, 1174, 10.1126/science.6474173
Simard, 2004, The neurobiology of glia in the context of water and ion homeostasis, Neuroscience, 129, 877, 10.1016/j.neuroscience.2004.09.053
Swanson, 2005, Astrocyte neurotransmitter uptake, 346
Verkhratsky, 2007, Glutamate-mediated neuronal-glial transmission, J Anat, 210, 651, 10.1111/j.1469-7580.2007.00734.x
Zerangue, 1996, Flux coupling in a neuronal glutamate transporter, Nature, 383, 634, 10.1038/383634a0
Kirischuk, 2007, Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells, Pflugers Arch, 454, 245, 10.1007/s00424-007-0207-5
Kirischuk, 1997, Na+/Ca2+ exchanger modulates kainate-triggered Ca2+ signaling in Bergmann glial cells in situ, Faseb J, 11, 566, 10.1096/fasebj.11.7.9212080
Minelli, 2007, Cellular and subcellular localization of Na+-Ca2+ exchanger protein isoforms, NCX1, NCX2, and NCX3 in cerebral cortex and hippocampus of adult rat, Cell Calcium, 41, 221, 10.1016/j.ceca.2006.06.004
Martinez-Hernandez, 1977, Glutamine synthetase: glial localization in brain, Science, 195, 1356, 10.1126/science.14400
Bowman, 1984, Excitatory amino acids directly depolarize rat brain astrocytes in primary culture, Nature, 311, 656, 10.1038/311656a0
Kettenmann, 1984, Aspartate, glutamate and gamma-aminobutyric acid depolarize cultured astrocytes, Neurosci Lett, 52, 25, 10.1016/0304-3940(84)90345-8
Kettenmann, 1984, Depolarization of cultured oligodendrocytes by glutamate and GABA, Neurosci Lett, 47, 271, 10.1016/0304-3940(84)90525-1
Bevan, 1985, The presence of voltage-gated sodium, potassium and chloride channels in rat cultured astrocytes, Proc R Soc Lond B Biol Sci, 225, 299, 10.1098/rspb.1985.0063
Blankenfeld, 1992, Ca2+ channel expression in the oligodendrocyte lineage, Eur J Neurosci, 4, 1035, 10.1111/j.1460-9568.1992.tb00130.x
Dave, 1991, Cerebral type 2 astroglia are heterogeneous with respect to their ability to respond to neuroligands linked to calcium mobilization, Glia, 4, 440, 10.1002/glia.440040503
Enkvist, 1989, Glutamate receptor-linked changes in membrane potential and intracellular Ca2+ in primary rat astrocytes, Glia, 2, 397, 10.1002/glia.440020602
Glaum, 1990, Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes, Proc Natl Acad Sci U S A, 87, 3454, 10.1073/pnas.87.9.3454
McCarthy, 1991, Pharmacologically-distinct subsets of astroglia can be identified by their calcium response to neuroligands, Neuroscience, 41, 325, 10.1016/0306-4522(91)90330-Q
Pearce, 1989, ATP-evoked Ca2+ mobilisation and prostanoid release from astrocytes: P2-purinergic receptors linked to phosphoinositide hydrolysis, J Neurochem, 52, 971, 10.1111/j.1471-4159.1989.tb02549.x
Sontheimer, 1991, Na+-current expression in rat hippocampal astrocytes in vitro: alterations during development, J Neurophysiol, 65, 3, 10.1152/jn.1991.65.1.3
Verkhratsky, 1990, Cultured glial precursor cells from mouse cortex express two types of calcium currents, Neurosci Lett, 112, 194, 10.1016/0304-3940(90)90202-K
Verkhratsky, 1996, Calcium-induced calcium release in neurones, Cell Calcium, 19, 1, 10.1016/S0143-4160(96)90009-3
Kirischuk, 1995, Subcellular heterogeneity of voltage-gated Ca2+ channels in cells of the oligodendrocyte lineage, Glia, 13, 1, 10.1002/glia.440130102
Verkhratsky, 2000, Ion channels in glial cells, Brain Res Brain Res Rev, 32, 380, 10.1016/S0165-0173(99)00093-4
Rodriguez, 2001, Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus, J Neurosci, 21, 823, 10.1523/JNEUROSCI.21-03-00823.2001
Kirischuk, 1995, ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells, J Neurosci, 15, 7861, 10.1523/JNEUROSCI.15-12-07861.1995
Kirischuk, 1996, Calcium signalling in mouse Bergmann glial cells mediated by a1-adrenoreceptors and H1 histamine receptors, Eur J Neurosci, 8, 1198, 10.1111/j.1460-9568.1996.tb01288.x
Kirischuk, 1996, Activation of P2-purino-, a1-adreno and H1-histamine receptors triggers cytoplasmic calcium signalling in cerebellar Purkinje neurons, Neuroscience, 73, 643, 10.1016/0306-4522(96)00205-9
Verkhratsky, 1998, Glial calcium: homeostasis and signaling function, Physiol Rev, 78, 99, 10.1152/physrev.1998.78.1.99
Kirischuk, 1999, Glutamate-triggered calcium signalling in mouse Bergmann glial cells in situ: role of inositol-1,4,5-trisphosphate-mediated intracellular calcium release, Neuroscience, 92, 1051, 10.1016/S0306-4522(99)00067-6
Karadottir, 2005, NMDA receptors are expressed in oligodendrocytes and activated in ischaemia, Nature, 438, 1162, 10.1038/nature04302
Lalo, 2006, NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes, J Neurosci, 26, 2673, 10.1523/JNEUROSCI.4689-05.2006
Lipton, 2006, NMDA receptors, glial cells, and clinical medicine, Neuron, 50, 9, 10.1016/j.neuron.2006.03.026
Araque, 1999, Tripartite synapses: glia, the unacknowledged partner, Trends Neurosci, 22, 208, 10.1016/S0166-2236(98)01349-6
Halassa, 2007, The tripartite synapse: roles for gliotransmission in health and disease, Trends Mol Med, 13, 54, 10.1016/j.molmed.2006.12.005
Giaume, 1998, Intercellular calcium signaling and gap junctional communication in astrocytes, Glia, 24, 50, 10.1002/(SICI)1098-1136(199809)24:1<50::AID-GLIA6>3.0.CO;2-4
Giaume, 2009, The barrel cortex as a model to study dynamic neuroglial interaction, Neuroscientist, 15, 351, 10.1177/1073858409336092
Houades, 2008, Gap junction-mediated astrocytic networks in the mouse barrel cortex, J Neurosci, 28, 5207, 10.1523/JNEUROSCI.5100-07.2008
Berridge, 2002, The endoplasmic reticulum: a multifunctional signaling organelle, Cell Calcium, 32, 235, 10.1016/S0143416002001823
Verkhratsky, 2002, The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death, Eur J Pharmacol, 447, 141, 10.1016/S0014-2999(02)01838-1
Verkhratsky, 2005, Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons, Physiol Rev, 85, 201, 10.1152/physrev.00004.2004
Kostyuk, 1994, Calcium stores in neurons and glia, Neuroscience, 63, 381, 10.1016/0306-4522(94)90537-1
Petersen, 2005, Calcium signalling: Past, present and future, Cell Calcium, 38, 161, 10.1016/j.ceca.2005.06.023
Verkhratsky, 2006, Calcium ions and integration in neural circuits, Acta Physiol (Oxf), 187, 357, 10.1111/j.1748-1716.2006.01566.x
Burdakov, 2005, Intraluminal calcium as a primary regulator of endoplasmic reticulum function, Cell Calcium, 38, 303, 10.1016/j.ceca.2005.06.010
Verkhratsky, 2002, The endoplasmic reticulum and neuronal calcium signalling, Cell Calcium, 32, 393, 10.1016/S0143416002001896
Wuytack, 2002, Molecular physiology of the SERCA and SPCA pumps, Cell Calcium, 32, 279, 10.1016/S0143416002001847
Solovyova, 2002, Monitoring of free calcium in the neuronal endoplasmic reticulum: an overview of modern approaches, J Neurosci Methods, 122, 1, 10.1016/S0165-0270(02)00300-X
Solovyova, 2002, Ca2+ dynamics in the lumen of the endoplasmic reticulum in sensory neurons: direct visualization of Ca2+-induced Ca2+ release triggered by physiological Ca2+ entry, Embo J, 21, 622, 10.1093/emboj/21.4.622
Petersen, 2001, The endoplasmic reticulum: one continuous or several separate Ca2+ stores?, Trends Neurosci, 24, 10.1016/S0166-2236(00)01787-2
Solovyova, 2003, Neuronal endoplasmic reticulum acts as a single functional Ca2+ store shared by ryanodine and inositol-1,4,5-trisphosphate receptors as revealed by intra-ER [Ca2+] recordings in single rat sensory neurones, Pflugers Arch, 446, 447, 10.1007/s00424-003-1094-z
Petersen, 2007, Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells, Cell Calcium, 42, 373, 10.1016/j.ceca.2007.05.012
Bezprozvanny, 2005, The inositol 1,4,5-trisphosphate receptors, Cell Calcium, 38, 261, 10.1016/j.ceca.2005.06.030
Deitmer, 1998, Calcium signalling in glial cells, Cell Calcium, 24, 405, 10.1016/S0143-4160(98)90063-X
Grosche, 1999, Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells, Nat Neurosci, 2, 139, 10.1038/5692
Cornell Bell, 1990, Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling, Science, 247, 470, 10.1126/science.1967852
Dani, 1992, Neuronal activity triggers calcium waves in hippocampal astrocyte networks, Neuron, 8, 429, 10.1016/0896-6273(92)90271-E
Scemes, 2006, Astrocyte calcium waves: what they are and what they do, Glia, 54, 716, 10.1002/glia.20374
Anderson, 2004, ATP-induced ATP release from astrocytes, J Neurochem, 88, 246, 10.1111/j.1471-4159.2004.02204.x
Arcuino, 2002, Intercellular calcium signaling mediated by point-source burst release of ATP, Proc Natl Acad Sci U S A, 99, 9840, 10.1073/pnas.152588599
Bennett, 2005, A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks, Biophys J, 89, 2235, 10.1529/biophysj.105.062968
Suadicani, 2006, P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling, J Neurosci, 26, 1378, 10.1523/JNEUROSCI.3902-05.2006
Angulo, 2008, GABA, a forgotten gliotransmitter, Prog Neurobiol, 86, 297, 10.1016/j.pneurobio.2008.08.002
Bezzi, 1998, Prostaglandins stimulate calcium-dependent glutamate release in astrocytes, Nature, 391, 281, 10.1038/34651
Bezzi, 2004, Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate, Nat Neurosci, 7, 613, 10.1038/nn1246
Fellin, 2004, Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors, Neuron, 43, 729, 10.1016/j.neuron.2004.08.011
Jourdain, 2007, Glutamate exocytosis from astrocytes controls synaptic strength, Nat Neurosci, 10, 331, 10.1038/nn1849
Oliet, 2009, Regulation of N-methyl-D-aspartate receptors by astrocytic D-serine, Neuroscience, 158, 275, 10.1016/j.neuroscience.2008.01.071
Volterra, 2005, Astrocytes, from brain glue to communication elements: the revolution continues, Nat Rev Neurosci, 6, 626, 10.1038/nrn1722
Parpura, 2008, Molecular form follows function: (un)snaring the SNAREs, Trends Neurosci, 31, 435, 10.1016/j.tins.2008.06.003
Reyes, 2009, The trinity of Ca2+ sources for the exocytotic glutamate release from astrocytes, Neurochem Int, 55, 2, 10.1016/j.neuint.2008.12.018
Cotrina, 1998, Connexins regulate calcium signaling by controlling ATP release, Proc Natl Acad Sci U S A, 95, 15735, 10.1073/pnas.95.26.15735
Duan, 2003, P2X7 receptor-mediated release of excitatory amino acids from astrocytes, J Neurosci, 23, 1320, 10.1523/JNEUROSCI.23-04-01320.2003
Kang, 2008, Connexin 43 hemichannels are permeable to ATP, J Neurosci, 28, 4702, 10.1523/JNEUROSCI.5048-07.2008
Pankratov, 2006, Vesicular release of ATP at central synapses, Pflugers Arch, 452, 589, 10.1007/s00424-006-0061-x
Perea, 2009, Tripartite synapses: astrocytes process and control synaptic information, Trends Neurosci, 32, 421, 10.1016/j.tins.2009.05.001
Alzheimer, 1910, Beiträge zur Kenntnis der pathologischen Neuroglia und ihrer Beziehungen zu den Abbauvorgängen im Nervengewebe, 401
Frommann, 1878
Nissl, 1899, Ueber einige Beziehungen zwischen Nervenzellerkrankungen und gliösen Erscheinungen bei verschiedenen Psychosen, Psychiat, 32, 1
Giaume, 2007, Glia: the fulcrum of brain diseases, Cell Death Differ, 14, 1324, 10.1038/sj.cdd.4402144
Nedergaard, 2010, Glial calcium and diseases of the nervous system, Cell Calcium, 47, 140, 10.1016/j.ceca.2009.11.010
Li, 2008, Protective role of reactive astrocytes in brain ischemia, J Cereb Blood Flow Metab, 28, 468, 10.1038/sj.jcbfm.9600546
Rossi, 2009, Astrocytic dysfunction: Insights on the role in neurodegeneration, Brain Res Bull, 80, 224, 10.1016/j.brainresbull.2009.07.012
Jabs, 2008, Astrocytic function and its alteration in the epileptic brain, Epilepsia, 49, 3, 10.1111/j.1528-1167.2008.01488.x
Seifert, 2006, Astrocyte dysfunction in neurological disorders: a molecular perspective, Nat Rev Neurosci, 7, 194, 10.1038/nrn1870
Tsai, 2002, Glutamatergic mechanisms in schizophrenia, Annu Rev Pharmacol Toxicol, 42, 165, 10.1146/annurev.pharmtox.42.082701.160735
Heneka, 2010, Neuroglia in neurodegeneration, Brain Res Rev, 63, 189, 10.1016/j.brainresrev.2009.11.004
Kano, 2009, Synapse elimination in the central nervous system, Curr Opin Neurobiol, 19, 154, 10.1016/j.conb.2009.05.002
Scheff, 2007, Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment, Neurology, 68, 1501, 10.1212/01.wnl.0000260698.46517.8f
Terry, 2000, Cell death or synaptic loss in Alzheimer disease, J Neuropathol Exp Neurol, 59, 1118, 10.1093/jnen/59.12.1118
Charcot, 1881, Amyotrophic lateral sclerosis: symptomatology, 192
Charcot, 1869, Deux cas d'atrophie musculaire progressive avec lesions de la substance grise et de faisceaux anterolateraux de la moelle epiniere, Arch Physiol Norm Pathol, 1, 354
Turner, 2008, Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS, Prog Neurobiol, 85, 94, 10.1016/j.pneurobio.2008.01.001
Rossi, 2008, Focal degeneration of astrocytes in amyotrophic lateral sclerosis, Cell Death Differ, 15, 1691, 10.1038/cdd.2008.99
Yamanaka, 2008, Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis, Nat Neurosci, 11, 251, 10.1038/nn2047
Johansson, 2007, Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET, J Neurol Sci, 255, 17, 10.1016/j.jns.2007.01.057
McGeer, 2002, Inflammatory processes in amyotrophic lateral sclerosis, Muscle Nerve, 26, 459, 10.1002/mus.10191
Parkinson, 1817
Mena, 2008, Glial cells as players in parkinsonism: the “good,” the “bad,” and the “mysterious” glia, Neuroscientist, 14, 544, 10.1177/1073858408322839
Broe, 2004, Astrocytic degeneration relates to the severity of disease in frontotemporal dementia, Brain, 127, 2214, 10.1093/brain/awh250
Kersaitis, 2004, Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies, Acta Neuropathol, 108, 515, 10.1007/s00401-004-0917-0
Potts, 2005, Thalamic dementia: an example of primary astroglial dystrophy of Seitelberger, Clin Neuropathol, 24, 271
Thompson, 2001, Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia, Ann Neurol, 49, 745, 10.1002/ana.1011
Vanzani, 2006, Regional differences in astrocyte activation in HIV-associated dementia, Medicina (B Aires), 66, 108
Dabir, 2004, Expression of the small heat-shock protein aB-crystallin in tauopathies with glial pathology, Am J Pathol, 164, 155, 10.1016/S0002-9440(10)63106-9
Forman, 2005, Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration, J Neurosci, 25, 3539, 10.1523/JNEUROSCI.0081-05.2005
Hazell, 2009, Astrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy, Neurochem Int, 55, 129, 10.1016/j.neuint.2009.02.020
Hazell, 2009, Loss of astrocytic glutamate transporters in Wernicke encephalopathy, Glia, 58, 148, 10.1002/glia.20908
Nagele, 2003, Astrocytes accumulate A b 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains, Brain Res, 971, 197, 10.1016/S0006-8993(03)02361-8
Nagele, 2004, Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease, Neurobiol Aging, 25, 663, 10.1016/j.neurobiolaging.2004.01.007
Rodriguez, 2009, Astroglia in dementia and Alzheimer's disease, Cell Death Differ, 16, 378, 10.1038/cdd.2008.172
Olabarria, 2010, Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease, Glia, 58, 831, 10.1002/glia.20967
Beach, 1988, Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex, Brain Res, 463, 357, 10.1016/0006-8993(88)90410-6
Griffin, 1989, Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease, Proc Natl Acad Sci U S A, 86, 7611, 10.1073/pnas.86.19.7611
Kashon, 2004, Associations of cortical astrogliosis with cognitive performance and dementia status, J Alzheimers Dis, 6, 595, 10.3233/JAD-2004-6604
Mrak, 2005, Glia and their cytokines in progression of neurodegeneration, Neurobiol Aging, 26, 349, 10.1016/j.neurobiolaging.2004.05.010
Sheng, 1996, Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease, Neurobiol Aging, 17, 359, 10.1016/0197-4580(96)00037-1
Meda, 2001, Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins, Neurobiol Aging, 22, 885, 10.1016/S0197-4580(01)00307-4
Simpson, 2010, Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain, Neurobiol Aging, 31, 578, 10.1016/j.neurobiolaging.2008.05.015
Wharton, 2009, Population variation in glial fibrillary acidic protein levels in brain aging: relationship to Alzheimer-type pathology and dementia, Dement Geriatr Cogn Disord, 27, 465, 10.1159/000217729
Mansour, 2008, Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability, Aging Cell, 7, 526, 10.1111/j.1474-9726.2008.00402.x
Ramirez, 2001, Changes of astrocytes in retinal ageing and age-related macular degeneration, Exp Eye Res, 73, 601, 10.1006/exer.2001.1061
Mouton, 2002, Age and gender effects on microglia and astrocyte numbers in brains of mice, Brain Res, 956, 30, 10.1016/S0006-8993(02)03475-3
Amenta, 1998, Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study, Microsc Res Tech, 43, 29, 10.1002/(SICI)1097-0029(19981001)43:1<29::AID-JEMT5>3.0.CO;2-H
Peinado, 1998, Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat, Microsc Res Tech, 43, 34, 10.1002/(SICI)1097-0029(19981001)43:1<34::AID-JEMT6>3.0.CO;2-G
Pilegaard, 1996, Total number of astrocytes in the molecular layer of the dentate gyrus of rats at different ages, Anal Quant Cytol Histol, 18, 279
Peters, 2008, The neuroglial population in the primary visual cortex of the aging rhesus monkey, Glia, 56, 1151, 10.1002/glia.20686
Pakkenberg, 2003, Aging and the human neocortex, Exp Gerontol, 38, 95, 10.1016/S0531-5565(02)00151-1
DeWitt, 1998, Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease, Exp Neurol, 149, 329, 10.1006/exnr.1997.6738
Abramov, 2003, Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity, J Neurosci, 23, 5088, 10.1523/JNEUROSCI.23-12-05088.2003
Abramov, 2004, b-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase, J Neurosci, 24, 565, 10.1523/JNEUROSCI.4042-03.2004
Kuchibhotla, 2009, Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice, Science, 323, 1211, 10.1126/science.1169096
Peters, 2009, Astrocyte function is modified by Alzheimer's disease-like pathology in aged mice, J Alzheimers Dis, 18, 177, 10.3233/JAD-2009-1140
Matos, 2008, Amyloid-b peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades, Neuroscience, 156, 10.1016/j.neuroscience.2008.08.022
Oddo, 2003, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Ab and synaptic dysfunction, Neuron, 39, 409, 10.1016/S0896-6273(03)00434-3
Kimelberg, 2004, The problem of astrocyte identity, Neurochem Int, 45, 191, 10.1016/j.neuint.2003.08.015
Senitz, 1995, Surface complexity of human neocortical astrocytic cells: changes with development, aging, and dementia, J Hirnforsch, 36, 531
Rossner, 2005, Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme, J Neurochem, 92, 226, 10.1111/j.1471-4159.2004.02857.x
Guenette, 2003, Astrocytes: a cellular player in Abeta clearance and degradation, Trends Mol Med, 9, 279, 10.1016/S1471-4914(03)00112-6
Nicoll, 2003, A new role for astrocytes: beta-amyloid homeostasis and degradation, Trends Mol Med, 9, 281, 10.1016/S1471-4914(03)00109-6
Apelt, 2003, Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques, Neurosci Lett, 339, 183, 10.1016/S0304-3940(03)00030-2
Wyss-Coray, 2003, Adult mouse astrocytes degrade amyloid-b in vitro and in situ, Nat Med, 9, 453, 10.1038/nm838
Rossner, 2001, Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology, J Neurosci Res, 64, 437, 10.1002/jnr.1095
Hartlage-Rubsamen, 2003, Astrocytic expression of the Alzheimer's disease b-secretase (BACE1) is stimulus-dependent, Glia, 41, 169, 10.1002/glia.10178
Heneka, 2005, Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice, J Neuroinflam, 2, 22, 10.1186/1742-2094-2-22
Martins, 2001, Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue, Neuroscience, 106, 557, 10.1016/S0306-4522(01)00289-5
Bell, 2009, Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease, Acta Neuropathol, 118, 103, 10.1007/s00401-009-0522-3
Iadecola, 2004, Neurovascular regulation in the normal brain and in Alzheimer's disease, Nat Rev Neurosci, 5, 347, 10.1038/nrn1387
Zlokovic, 2008, The blood-brain barrier in health and chronic neurodegenerative disorders, Neuron, 57, 178, 10.1016/j.neuron.2008.01.003
Farkas, 2001, Cerebral microvascular pathology in aging and Alzheimer's disease, Prog Neurobiol, 64, 575, 10.1016/S0301-0082(00)00068-X
Abbott, 2006, Astrocyte-endothelial interactions at the blood-brain barrier, Nat Rev Neurosci, 7, 41, 10.1038/nrn1824
Mosconi, 2008, Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease, Ann N Y Acad Sci, 1147, 180, 10.1196/annals.1427.007
Parpura-Gill, 1997, The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes, Brain Res, 754, 65, 10.1016/S0006-8993(97)00043-7
Schubert, 2009, The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide, Eur J Neurosci, 29, 1323, 10.1111/j.1460-9568.2009.06712.x
Soucek, 2003, The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide, Neuron, 39, 43, 10.1016/S0896-6273(03)00367-2
Allaman, 2010, Amyloid-b aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability, J Neurosci, 30, 3326, 10.1523/JNEUROSCI.5098-09.2010
Blass, 2000, Inherent abnormalities in energy metabolism in Alzheimer disease, Ann N Y Acad Sci, 903, 204, 10.1111/j.1749-6632.2000.tb06370.x
Liang, 2008, Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons, Proc Natl Acad Sci U S A, 105, 4441, 10.1073/pnas.0709259105
Bigl, 1999, Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease, J Neural Transm, 106, 499, 10.1007/s007020050174
Coleman, 2004, A focus on the synapse for neuroprotection in Alzheimer disease and other dementias, Neurology, 63, 1155, 10.1212/01.WNL.0000140626.48118.0A
Elias, 2000, The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort, Arch Neurol, 57, 808, 10.1001/archneur.57.6.808
DeKosky, 1990, Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity, Ann Neurol, 27, 457, 10.1002/ana.410270502
Samuel, 1994, Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model, Neurology, 44, 2081, 10.1212/WNL.44.11.2081
Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann Neurol, 30, 572, 10.1002/ana.410300410
Alle, 2009, Energy-efficient action potentials in hippocampal mossy fibers, Science, 325, 1405, 10.1126/science.1174331
Biran, 2009, Pharmacotherapeutic targets in Alzheimer's disease, J Cell Mol Med, 13, 61, 10.1111/j.1582-4934.2008.00595.x
McCall, 1996, Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology, Proc Natl Acad Sci U S A, 93, 6361, 10.1073/pnas.93.13.6361
Shibuki, 1996, Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice, Neuron, 16, 587, 10.1016/S0896-6273(00)80078-1
Guarente, 2000, Genetic pathways that regulate ageing in model organisms, Nature, 408, 255, 10.1038/35041700
Doble, 1996, The pharmacology and mechanism of action of riluzole, Neurology, 47, S233, 10.1212/WNL.47.6_Suppl_4.233S
Frizzo, 2004, Riluzole enhances glutamate uptake in rat astrocyte cultures, Cell Mol Neurobiol, 24, 123, 10.1023/B:CEMN.0000012717.37839.07
Ji, 2005, Beta-lactam antibiotics are multipotent agents to combat neurological diseases, Biochem Biophys Res Commun, 333, 661, 10.1016/j.bbrc.2005.05.014