Astrocyte tissue factor controls CNS hemostasis and autoimmune inflammation

Thrombosis Research - Tập 141 - Trang S65-S67 - 2016
Shaobin Wang1, Brandi Reeves2, Rafal Pawlinski1,2
1McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
2Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Tài liệu tham khảo

Henrich-Noack, 2006, Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra, Brain research, 1070, 232, 10.1016/j.brainres.2005.10.100 Park, 2010, Activation of microglial cells via protease-activated receptor 2 mediates neuronal cell death in cultured rat primary neuron, Nitric oxide: biology and chemistry/official journal of the Nitric Oxide Society, 22, 18, 10.1016/j.niox.2009.10.008 Striggow, 2001, Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia, The European journal of neuroscience, 14, 595, 10.1046/j.0953-816x.2001.01676.x Wang, 2004, Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling, Neuroscience, 126, 69, 10.1016/j.neuroscience.2004.03.024 Drake, 1989, Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis, Am J Pathol, 134, 1087 Fleck, 1990, Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody, Thromb Res, 59, 421, 10.1016/0049-3848(90)90148-6 Eddleston, 1993, Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis, J Clin Invest, 92, 349, 10.1172/JCI116573 Thomas, 1993, Tissue factor contributes to microvascular defects after focal cerebral ischemia, Stroke, 24, 847, 10.1161/01.STR.24.6.847 Nagai, 2010, Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis, Neurosurgery, 66, 560, 10.1227/01.NEU.0000365745.49583.FD Gavins, 2011, Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S, Blood, 117, 4125, 10.1182/blood-2010-08-301366 Wang, 2014, Abstract 76: Astrocyte Tissue Factor: Double-Edged Sword of Brain Hemostasis, Arteriosclerosis, Thrombosis, and Vascular Biology, 34, A76, 10.1161/atvb.34.suppl_1.76 Lo, 2003, Mechanisms, challenges and opportunities in stroke, Nat Rev Neurosci, 4, 399, 10.1038/nrn1106 van Asch, 2010, Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis, The Lancet Neurology, 9, 167, 10.1016/S1474-4422(09)70340-0 Matsushita, 2000, Evidence for apoptosis after intercerebral hemorrhage in rat striatum, J Cereb Blood Flow Metab, 20, 396, 10.1097/00004647-200002000-00022 Davis, 2006, Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage, Neurology, 66, 1175, 10.1212/01.wnl.0000208408.98482.99 Wagner, 2003, Heme and iron metabolism: role in cerebral hemorrhage, J Cereb Blood Flow Metab, 23, 629, 10.1097/01.WCB.0000073905.87928.6D Gaasch, 2007, Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells, Neurochem Res, 32, 1196, 10.1007/s11064-007-9290-4 Wang, 2014, Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage, Ann Neurol, 75, 876, 10.1002/ana.24159 Egashira, 2015, Intercellular cross-talk in intracerebral hemorrhage, Brain research, 1623, 97, 10.1016/j.brainres.2015.04.003 Liu, 2010, Blood-brain barrier breakdown and repair by Src after thrombin-induced injury, Ann Neurol, 67, 526, 10.1002/ana.21924 Lekic, 2015, Protease-activated receptor 1 and 4 signal inhibition reduces preterm neonatal hemorrhagic brain injury, Stroke, 46, 1710, 10.1161/STROKEAHA.114.007889 Mayer, 2005, Recombinant activated factor VII for acute intracerebral hemorrhage, N Engl J Med, 352, 777, 10.1056/NEJMoa042991 Mayer, 2008, Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage, N Engl J Med, 358, 2127, 10.1056/NEJMoa0707534 Striggow, 2000, The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations, Proc Natl Acad Sci U S A, 97, 2264, 10.1073/pnas.040552897 Granziera, 2007, Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase, Brain research, 1148, 217, 10.1016/j.brainres.2007.02.025 Donovan, 1997, Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities, J Neurosci, 17, 5316, 10.1523/JNEUROSCI.17-14-05316.1997 Chen, 2010, Thrombin mediates severe neurovascular injury during ischemia, Stroke, 41, 2348, 10.1161/STROKEAHA.110.584920 Choi, 2005, Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase, J Neurosci, 25, 4082, 10.1523/JNEUROSCI.4306-04.2005 Xue, 2001, Acute tissue damage after injections of thrombin and plasmin into rat striatum, Stroke, 32, 2164, 10.1161/hs0901.095408 Junge, 2003, The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia, Proc Natl Acad Sci U S A, 100, 13019, 10.1073/pnas.2235594100 Wang, 2012, Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia, Stroke, 43, 2476, 10.1161/STROKEAHA.112.661819 Okada, 1994, Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion, Stroke, 25, 1847, 10.1161/01.STR.25.9.1847 Mao, 2010, Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice, J Cereb Blood Flow Metab, 30, 1044, 10.1038/jcbfm.2009.283 Sandercock, 2015, Anticoagulants for acute ischaemic stroke, Cochrane Database Syst Rev, 3, 10.1002/14651858.CD000024.pub4 Hankey, 2012, Anticoagulant therapy for patients with ischaemic stroke, Nat Rev Neurol, 8, 319, 10.1038/nrneurol.2012.77 Granger, 2012, Newer oral anticoagulants should be used as first-line agents to prevent thromboembolism in patients with atrial fibrillation and risk factors for stroke or thromboembolism, Circulation, 125, 159, 10.1161/CIRCULATIONAHA.111.031146 Prabhakaran, 2015, Acute stroke intervention: a systematic review, JAMA, 313, 1451, 10.1001/jama.2015.3058 Cheng, 2003, Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective, Nature medicine, 9, 338, 10.1038/nm826 Liu, 2004, Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C, Nature medicine, 10, 1379, 10.1038/nm1122 Cheng, 2006, Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage, Nature medicine, 12, 1278, 10.1038/nm1498 Wang, 2012, An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents, Stroke, 43, 2444, 10.1161/STROKEAHA.112.658997 Marik, 2007, Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?, Brain, 130, 2800, 10.1093/brain/awm236 Adams, 2007, The fibrin-derived gamma 377–395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease, J Exp Med, 204, 571, 10.1084/jem.20061931 Davalos, 2012, Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation, Nature communications, 3, 1227, 10.1038/ncomms2230 Ryu, 2015, Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation, Nature communications, 6, 8164, 10.1038/ncomms9164 Han, 2008, Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets, Nature, 451, 1076, 10.1038/nature06559 Kim, 2015, Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood-brain barrier, Journal of neurochemistry, 135, 577, 10.1111/jnc.13285 Griffin, 2015, Activated protein C: biased for translation, Blood, 125, 2898, 10.1182/blood-2015-02-355974 Noorbakhsh, 2006, Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis, The Journal of experimental medicine, 203, 425, 10.1084/jem.20052148