Astaxanthin: Nguồn gốc, Quy trình Chiết xuất, Độ bền, Hoạt tính Sinh học và Ứng dụng Thương mại - Một Tổng quan

Goycoolea, 2006, Astaxanthin: A review of its chemistry and applications, Crit. Rev. Food Sci. Nutr., 46, 185, 10.1080/10408690590957188

Pashkow, 2008, Astaxanthin: A novel potential treatment for oxidative stress and inflammation in cardiovascular disease, Am. J. Cardiol., 101, 58D, 10.1016/j.amjcard.2008.02.010

Roche, F. (1987). Astaxanthin As a Pigmenter in Salmon Feed, Color Additive Petition 7C02 1 1, United States Food and Drug Administration, Hoffman-La Roche Ltd.

Sarada, 2002, Influence of stress on astaxanthin production in Haematococcus pluvialis grown under different culture conditions, Process Biochem., 37, 623, 10.1016/S0032-9592(01)00246-1

Ranga Rao, A. (2011). Production of astaxanthin from cultured green alga Haematococcus pluvialis and its biological activities. [Ph.D. Thesis, University of Mysore].

Sarada, 2012, Influence of different culture conditions on yield of biomass and value added products in microalgae, Dyn. Biochem. Proc. Biotechnol. Mol. Biol., 6, 77

Kidd, 2011, Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential, Altern. Med. Rev., 16, 355

Guerin, 2003, Haematococcus astaxanthin: Applications for human health and nutrition, Trends Biotechnol., 21, 210, 10.1016/S0167-7799(03)00078-7

Yang, 2013, Astaxanthin structure, metabolism, and health benefits, J. Hum. Nutr. Food Sci., 1, 1003:1

Hussein, 2006, Astaxanthin, a carotenoid with potential in human health and nutrition, J. Nat. Prod., 69, 443, 10.1021/np050354+

Yuan, 2011, Potential health promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae, Mol. Nutr. Food Res., 55, 150, 10.1002/mnfr.201000414

Yamashita, 2013, Astaxanthin as a medical food, Funct. Foods Health Dis., 3, 254, 10.31989/ffhd.v3i7.49

Dhankhar, 2012, Astaxanthin: A potential carotenoid, Int. J. Pharm. Sci. Res., 3, 1246

Sindhuja, 2013, Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis, J. Agric. Food Chem., 61, 3842, 10.1021/jf304609j

Baskaran, 2013, In vivo bioavailability and antioxidant activity of carotenoids from micro algal biomass—A repeated dose study, Food Res. Int., 54, 711, 10.1016/j.foodres.2013.07.067

Aradhya, 2010, Antibacterial properties of Spirulina platensis, Haematococcus pluvialis, Botryococcus braunii micro algal extracts, Curr. Trends Biotechnol. Pharm., 4, 809

Baskaran, 2010, Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model, J. Agric. Food Chem., 58, 8553, 10.1021/jf101187k

Sarada, 2009, Identification of carotenoids from green alga Haematococcus pluvialis by HPLC and LC-MS (APCI) and their antioxidant properties, J. Microbiol. Biotechnol., 19, 1333

Lorenz, R.T. (1999). A Technical Review of Haematococcus Algae, Cyanotech Corporation. NatuRose™ Technical Bulletin #060.

EFSA (European Food Safety Authority) (2005). Opinion of the scientific panel on additives and products or substances used in animal feed on the request from the European commission on the safety of use of colouring agents in animal human nutrition. EFSA J., 291, 1–40.

Iwamoto, 2000, Inhibition of low-density lipoprotein oxidation by astaxanthin, J. Atheroscler. Thromb., 7, 216, 10.5551/jat1994.7.216

Aflalo, 2007, On the relative efficiency of two- vs. one-stage production of astaxanthin by the green alga Haematococcus pluvialis, Biotechnol. Bioeng., 98, 300, 10.1002/bit.21391

Torzillo, 2003, Interplay between photochemical activities and pigment composition in an outdoor culture of Haematococcus pluvialis during the shift from the green to red stage, J. Appl. Phycol., 15, 127, 10.1023/A:1023854904163

Olaizola, 2000, Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors, J. Appl. Phycol., 12, 499, 10.1023/A:1008159127672

Wang, 2013, Effect of initial biomass density on growth and astaxanthin production of Haematococcus pluvialis in an outdoor photobioreactor, J. Appl. Phycol., 25, 253, 10.1007/s10811-012-9859-4

Zhang, 1997, Enhanced accumulation of secondary carotenoids in a mutant of the green alga, Chlorococcum sp, J. Appl. Phycol., 9, 459, 10.1023/A:1007902103419

Zhang, 1997, Composition and accumulation of secondary carotenoids in Chlorococcum sp, J. Appl. Phycol., 9, 147, 10.1023/A:1007926528388

Wang, 2008, Growth associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta), World J. Microbiol. Biotechnol., 24, 1915, 10.1007/s11274-008-9692-8

Orosa, 2000, Production and analysis of secondary carotenoids in green algae, J. Appl. Phycol., 12, 553, 10.1023/A:1008173807143

Banerjee, 2009, Biochemical composition of marine macroalgae from gangetic delta at the apex of Bay of Bengal, Afr. J. Basic Appl. Sci., 1, 96

Yokoyama, 1995, New carotenoid glucosides, astaxanthin glucoside and adonimxanthin glucoside, isolated from the astaxanthin producing marine bacterium, Agrobacterium aurantiacum, J. Nat. Prod., 58, 1929, 10.1021/np50126a022

EFSA (European Food Safety Authority) (2007). Safety and efficacy of panaferd-AX(red carotenoid rich bacterium Paracoccus carotinifaciens as feed additive for salmon and trout. EFSA J., 546, 1–30.

Kim, 2005, High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs, Biosci. Biotechnol. Biochem., 69, 1743, 10.1271/bbb.69.1743

Schleissner, 2010, High-titer production of astaxanthin by the semi-industrial fermentation of Xanthophyllomyces dendrorhous, J. Biotechnol., 148, 144, 10.1016/j.jbiotec.2010.05.004

Yamaoka, Y. (2008). Microorganism and production of carotenoid compounds. (7,374,908 B2), U.S. Patent.

Meyers, 1981, Characterization of astaxanthin pigments from heat processed crawfish waste, J. Agric. Food Chem., 3, 505, 10.1021/jf00105a017

Foss, 1987, Natural occurrence of enantiomeric and meso astaxanthin. 7-crustaceans including zooplankton, Comp. Biochem. Physiol. B, 86B, 313, 10.1016/0305-0491(87)90298-7

Sarada, 2006, An efficient method for extraction of astaxanthin from green alga Haematococcus pluvialis, J. Agric. Food Chem., 54, 7585, 10.1021/jf060737t

Kobayashi, 1997, Selective extraction of astaxanthin and chlorophyll from the green alga Haematococcus pluvialis, Biotechnol. Tech., 11, 657, 10.1023/A:1018455209445

Raposo, 2001, Evaluation of different cell disruption processes on encysted cells of Haematococcus pluvialis: Effects on astaxanthin recovery and implications for bio-availability, J. Appl. Phycol., 13, 19, 10.1023/A:1008183429747

Kang, 2008, Direct extraction of astaxanthin from Haematococcus culture using vegetable oils, Biotechnol. Lett., 30, 441, 10.1007/s10529-007-9578-0

Ni, 2008, Optimization of acidic extraction of astaxanthin from Phaffia rhodozyma, J. Zhejiang Univ. Sci. B, 9, 51, 10.1631/jzus.B061261

Shotipruk, 2010, Comparison of extraction methods for recovery of astaxanthin from Haematococcus pluvialis, Sep. Sci. Technol., 46, 64, 10.1080/01496395.2010.493546

Storebakken, 2004, Stability of astaxanthin from the red yeast, Xanthophyllomyces dendrorhous, during feed processing: Effects of enzymatic cell wall disruption and extrusion temperature, Aquaculture, 231, 489, 10.1016/j.aquaculture.2003.10.034

Machmudah, 2006, Extraction of astaxanthin from Haematococcus pluvialis using supercritical CO2 and ethanol as entrainer, Ind. Eng. Chem. Res., 45, 3652, 10.1021/ie051357k

Nobre, 2006, Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis, Eur. Food Res. Technol., 223, 787, 10.1007/s00217-006-0270-8

Wang, 2012, Supercritical fluid extraction of astaxanthin from Haematococcus pluvialis and its antioxidant potential in sunflower oil, Innov. Food Sci. Emerg. Technol., 13, 120, 10.1016/j.ifset.2011.09.004

Sarada, 2007, Stabilization of astaxanthin in edible oils and its use as an antioxidant, J. Sci. Food Agric., 87, 957, 10.1002/jsfa.2766

Anarjan, 2013, Chemical stability of astaxanthin nanodispersions in orange juice and skimmed milk as model food systems, Food Chem., 139, 527, 10.1016/j.foodchem.2013.01.012

Raposo, 2012, Effects of spray drying and storage on astaxanthin content of Haematococcus pluvialis biomass, World J. Microbiol. Biotechnol., 28, 1253, 10.1007/s11274-011-0929-6

2013, Production and stability of water-dispersible astaxanthin oleoresin from Phaffia rhodozyma, Int. J. Food Sci. Technol., 48, 1243, 10.1111/ijfs.12083

Yuan, 2013, Storage stability and antioxidant activity of complex of astaxanthin with hydroxypropyl-β-cyclodextrin, Carbohydr. Polym., 91, 385, 10.1016/j.carbpol.2012.08.059

Goycoolea, 2004, Microencapsulation of astaxanthin in a chitosan matrix, Carbohydr. Polym., 56, 41, 10.1016/j.carbpol.2003.11.012

Tachaprutinun, 2009, Preventing the thermal degradation of astaxanthin through nanoencapsulation, Int. J. Pharm., 374, 119, 10.1016/j.ijpharm.2009.03.001

Ribeiro, 2005, Production of O/W emulsions containing astaxanthin by repeated premix membrane emulsification, J. Food Sci., 70, E117, 10.1111/j.1365-2621.2005.tb07083.x

Chen, 2007, The preparation and stability of the inclusion complex of astaxanthin with β-cyclodextrin, Food Chem., 101, 1580, 10.1016/j.foodchem.2006.04.020

Barros, 2012, Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils, Chem. Biol. Interact., 197, 58, 10.1016/j.cbi.2012.03.005

Otton, 2012, Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function, Eur. J. Nutr., 51, 707, 10.1007/s00394-011-0250-z

Page, 2002, Astaxanthin and canthaxanthin do not induce liver or kidney xenobiotic-metabolizing enzymes in rainbow trout (Oncorhynchus mykiss Walbaum), Comp. Biochem. Physiol. C Toxicol. Pharmacol., 133C, 443, 10.1016/S1532-0456(02)00168-0

Osterlie, 2000, Plasma appearance and distribution of astaxanthin E/Z isomers in plasma lipoproteins of after single dose administration of astaxanthin, J. Nutr. Biochem., 11, 482, 10.1016/S0955-2863(00)00104-2

Okada, 2009, Bioavailability of astaxanthin in Haematococcus algal extract: the effects of timing of diet and smoking habits, Biosci. Biotechnol. Biochem., 73, 1928, 10.1271/bbb.90078

Olson, 2004, Carotenoids: absorption, transport, and metabolism of carotenoids in humans, Pure Appl. Chem., 66, 1011, 10.1351/pac199466051011

Naguib, 2000, Antioxidant activities of astaxanthin and related carotenoids, J. Agric. Food Chem., 48, 1150, 10.1021/jf991106k

Liu, 2007, Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all trans isomer, Biochem. Biophys. Res. Commun., 357, 187, 10.1016/j.bbrc.2007.03.120

Miki, 1991, Biological functions and activities of animal carotenoids, Pure Appl. Chem., 63, 141, 10.1351/pac199163010141

Martin, 1999, Anti and pro-oxidant properties of carotenoids, J. Prakt. Chem., 341, 302, 10.1002/(SICI)1521-3897(199904)341:3<302::AID-PRAC302>3.0.CO;2-6

Augusti, 2012, Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits, J. Clin. Biochem. Nutr., 51, 42, 10.3164/jcbn.11-74

Kamath, 2008, Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis, Eur. J. Pharmacol., 590, 387, 10.1016/j.ejphar.2008.06.042

Goto, 2001, Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin, Biochim. Biophys. Acta, 1512, 251, 10.1016/S0005-2736(01)00326-1

Liu, 2003, Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori infected BALB/c mice, Int. Immunopharmacol., 3, 979, 10.1016/S1567-5769(03)00096-1

Bennedsen, 1999, Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes, Immunol. Lett., 70, 185, 10.1016/S0165-2478(99)00145-5

Park, 2010, Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans, Nutr. Metab., 7, 1, 10.1186/1743-7075-7-18

Haines, 2011, Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: A comparison with ibuprofen, Phytother. Res., 25, 128, 10.1002/ptr.3160

Ohgami, 2003, Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo, Invest. Ophthalmol. Vis. Sci., 44, 2694, 10.1167/iovs.02-0822

Suzuki, 2006, Suppressive effects of astaxanthin against rat endotoxin induced uveitis by inhibiting the NF-kB signaling pathway, Exp. Eye Res., 82, 275, 10.1016/j.exer.2005.06.023

Hama, 2012, Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage, J. Pharm. Sci., 101, 2909, 10.1002/jps.23216

Santos, 2012, Shrimp waste extract and astaxanthin: Rat alveolar macrophage, oxidative stress and inflammation, J. Food Sci., 77, 141, 10.1111/j.1750-3841.2012.02762.x

Uchiyama, 2002, Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice, Redox Rep., 7, 290, 10.1179/135100002125000811

Otton, 2010, Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats, Chem. Biol. Interact., 186, 306, 10.1016/j.cbi.2010.05.011

Nakano, 2008, Effect of astaxanthin in combination with α-tocopherol or ascorbic acid against oxidative damage in diabetic ODS rats, J. Nutr. Sci. Vitaminol., 54, 329, 10.3177/jnsv.54.329

Nishigaki, 2010, Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells, Phytother. Res., 24, 54, 10.1002/ptr.2867

Hussein, 2007, Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp, Life Sci., 80, 522, 10.1016/j.lfs.2006.09.041

Bhuvaneswari, 2010, Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed an obesity-promoting diet, Process Biochem., 45, 1406, 10.1016/j.procbio.2010.05.016

Bhuvaneswari, S., Yogalakshmi, B., Sreeja, S., and Anuradha, C.V. (2013). Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice. Cell Stress Chaperones, in press.

Naito, 2004, Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice, BioFactors, 20, 49, 10.1002/biof.5520200105

Kim, 2009, Protection against oxidative stress, inflammation, and apoptosis of high glucose- exposed proximal tubular epithelial cells by astaxanthin, J. Agric. Food Chem., 57, 8793, 10.1021/jf9019745

Manabe, 2008, Astaxanthin protects mesangial cells from hyperglycemia induced oxidative signaling, J. Cell Biochem., 103, 1925, 10.1002/jcb.21583

Fassett, 2011, Astaxanthin: A potential therapeutic agent in cardiovascular disease, Mar. Drugs, 9, 447, 10.3390/md9030447

Lauver, 2005, Disodium disuccinate astaxanthin (Cardax) attenuates complement activation and reduces myocardial injury following ischemia/reperfusion, J. Pharmacol. Exp. Ther., 314, 686, 10.1124/jpet.105.087114

Gross, 2005, Acute and chronic administration of disodium disuccinate astaxanthin (Cardax) produces marked cardioprotection in dog hearts, Mol. Cell. Biochem., 272, 221, 10.1007/s11010-005-7555-2

Gross, 2006, Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats, Mol. Cell. Biochem., 283, 23, 10.1007/s11010-006-2217-6

Sevilla, 2011, Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats, Pharmacol. Res., 63, 44, 10.1016/j.phrs.2010.09.003

Khan, 2010, Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model, Thromb. Res., 126, 299, 10.1016/j.thromres.2010.07.003

Nakao, 2010, Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c mice, Anticancer Res., 30, 2721

Ryu, 2012, Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels and progression of atherosclerosis in LDLR and ApoE mice, Atherosclerosis, 222, 99, 10.1016/j.atherosclerosis.2012.02.002

Wolf, 1992, Retinoids and carotenoids as inhibitors of carcinogenesis and inducers of cell-cell communication, Nutr. Rev., 50, 270, 10.1111/j.1753-4887.1992.tb01345.x

Hanusch, 1995, Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin, Arch. Biochem. Biophys., 317, 423, 10.1006/abbi.1995.1184

Hix, 2006, Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives, Cancer Lett., 211, 25, 10.1016/j.canlet.2004.01.036

Daubrawa, 2005, Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts, J. Nutr., 135, 2507, 10.1093/jn/135.11.2507

Zhang, 1991, Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action, Carcinogenesis, 12, 2109, 10.1093/carcin/12.11.2109

Zhang, 1992, Carotenoids up-regulate connexin-43 gene expression independent of their provitamin A or antioxidant properties, Cancer Res., 52, 5707

Chew, 2004, Carotenoid action on the immune response, J. Nutr., 134, 257S, 10.1093/jn/134.1.257S

Chew, 1999, A comparison of the anticancer activities of dietary β-carotene, canthaxanthin and astaxanthin in mice in vivo, Anticancer Res., 19, 1849

Palozza, 2009, Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells, Cancer Lett., 283, 108, 10.1016/j.canlet.2009.03.031

Tanaka, 1995, Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophyll’s, astaxanthin and canthaxanthin, Cancer Res., 55, 4059

Tanaka, 1994, Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin, Carcinogenesis, 15, 15, 10.1093/carcin/15.1.15

Jyonouchi, 2000, Antitumor activity of astaxanthin and its mode of action, Nutr. Cancer, 36, 59, 10.1207/S15327914NC3601_9

Prabhu, 2009, Antioxidative and anti-proliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazineinduced experimental colon carcinogenesis, Fund. Clin. Pharmacol., 23, 225, 10.1111/j.1472-8206.2009.00669.x

Nakao, 2010, Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c mice, Anticancer Res., 30, 2171

Maoka, 2012, Anti-oxidative, anti-tumor-promoting, and anti-carcinogenesis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite, Mar. Drugs, 10, 1391, 10.3390/md10061391

Jyonouchi, 1991, Studies of immunomodulating actions of carotenoids. I. Effects of β-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system, Nutr. Cancer, 16, 93, 10.1080/01635589109514148

Jyonouchi, 1994, Immunomodulating actions of carotenoids: Enhancement of in vivo and in vitro antibody production to T-dependent antigens, Nutr. Cancer, 21, 47, 10.1080/01635589409514303

Jyonouchi, 1995, Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen, Nutr. Cancer, 23, 171, 10.1080/01635589509514373

Park, 2011, Astaxanthin stimulates cell-mediated and humoral immune responses in cats, Vet. Immunol. Immunopathol., 144, 455, 10.1016/j.vetimm.2011.08.019

Choi, 2011, Pharmacokinetics and first-pass metabolism of astaxanthin in rats, Br. J. Nutr., 105, 220, 10.1017/S0007114510003454

Sila, 2013, Antioxidant and anti-proliferative activities of astaxanthin extracted from the shell waste of deep-water pink shrimp (Parapenaeus longirostris), Nat. Prod. J., 3, 82

Kim, 2011, Protective effects of Haematococcus astaxanthin on oxidative stress in healthy smokers, J. Med. Food, 14, 1469, 10.1089/jmf.2011.1626

Nakagawa, 2011, Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes, Br. J. Nutr., 105, 1563, 10.1017/S0007114510005398

Yang, 2011, Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice, J. Nutr., 141, 1611, 10.3945/jn.111.142109

Ishiki, 2013, Impact of divergent effects of astaxanthin on insulin signaling in l6 cells, Endocrinology, 154, 2600, 10.1210/en.2012-2198

Huangfu, 2013, Anti-ageing effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress, J. Agric. Food Chem., 6, 7800, 10.1021/jf402224w

Chew, 2013, Astaxanthin decreases inflammatory biomarkers associated with cardiovascular disease in human umbilical vein endothelial cells, Am. J. Adv. Food Sci. Technol., 1, 1

Park, 2013, Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs, J. Animal Sci., 91, 268, 10.2527/jas.2012-5341

Gal, 2012, Effects of astaxanthin supplementation on chemically induced tumorigenesis in Wistar rats, Acta Vet. Scand., 54, 1, 10.1186/1751-0147-54-50

Wibrand, 2013, Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats, Lipids Health Dis., 12, 1, 10.1186/1476-511X-12-6

Turkez, 2012, Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats, Toxicol. Ind. Health, 29, 591, 10.1177/0748233711434959

Chan, 2012, Anti-coagulatory and anti-inflammatory effects of astaxanthin in diabetic rats, J. Food Sci., 77, H76, 10.1111/j.1750-3841.2011.02558.x

Dong, 2013, Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress, Mar. Drugs, 11, 960, 10.3390/md11030960

Iizuka, 2012, Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages, J. Nutr. Sci. Vitaminol. (Tokyo), 58, 96, 10.3177/jnsv.58.96

Yoshida, 2010, Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia, Atherosclerosis, 209, 520, 10.1016/j.atherosclerosis.2009.10.012

Chang, 2010, Astaxanthin secured apoptic death of PC12 cells induced by β-amyloid peptide 25–35: Its molecular action targets, J. Med. Food, 13, 548, 10.1089/jmf.2009.1291

Lu, 2010, Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo, Brain Res., 1360, 40, 10.1016/j.brainres.2010.09.016

Stewart, 2008, Safety assessment of astaxanthin rich microalgae biomass: acute and subchronic toxicity studies in rats, Food Chem. Toxicol., 46, 3030, 10.1016/j.fct.2008.05.038

Hussein, 2005, Antihypertensive and neuroprotective effects of astaxanthin in experimental animals, Biol. Pharm. Bull., 28, 47, 10.1248/bpb.28.47

Kim, 2005, Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats, Eur. J. Pharmacol., 514, 53, 10.1016/j.ejphar.2005.03.034

Petri, 2007, Tissue distribution of astaxanthin in rats following exposure to graded levels in the feed, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 145, 202, 10.1016/j.cbpc.2006.12.008

Murata, 2012, Protective effects of astaxanthin from paracoccus carotinifaciens on murine gastric ulcer models, Phytother. Res., 26, 1126, 10.1002/ptr.3681

Odeberg, 2003, Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations, Eur. J. Pharm. Sci., 19, 299, 10.1016/S0928-0987(03)00135-0

Serebruany, 2010, The in vitro effects of xancor, a synthetic astaxanthine derivative, on hemostatic biomarkers in aspirin-naive and aspirin-treated subjects with multiple risk factors for vascular disease, Am. J. Ther., 17, 125, 10.1097/MJT.0b013e31819cdbbd

Spiller, 2003, Safety of an astaxanthin rich Haemaotoccu pluvialis algal extract: A randomized clinical trial, J. Med. Food, 6, 51, 10.1089/109662003765184741

Miyawaki, 2008, Effects of astaxanthin on human blood rheology, J. Clin. Biochem. Nutr., 43, 69, 10.3164/jcbn.2008048

Karppi, 2007, Effects of astaxanthin supplementation on lipid peroxidation, Int. J. Vitam. Nutr. Res., 77, 3, 10.1024/0300-9831.77.1.3

Parisi, 2008, Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after one year, Ophthalmology, 115, 324, 10.1016/j.ophtha.2007.05.029

Katagiri, 2012, Effects of astaxanthin rich Haematococcus pluvialis extact on cognitive function: Arandomised double blind, placebo-controlled study, J. Clin. Biochem. Nutr., 51, 102, 10.3164/jcbn.D-11-00017

Tominaga, 2012, Cosmetic benefits of astaxanthin on humans subjects, Acta Biochim. Pol., 59, 43, 10.18388/abp.2012_2168

Hashimoto, 2013, Effects of astaxanthin on antioxidation in human aqueous humor, J. Clin. Biochem. Nutr., 53, 1, 10.3164/jcbn.13-6

Chew, B.P., and Park, J.S. (2006). Natural astaxanthin extract reduces DNA oxidation. (US20060217445), Patent.

Tsuji, S., Shirasawa, T., and Shimizu, T. (2007). Neurocyte protective agent. (US20070293568), Patent.

Leigh, S., Steven Leight, M.L., and Hogevest, P.V. (2007). Crystal forms of astaxanthin. (US20080234521), Patent.

Lockwood, S.F., and Preston, M. (2008). Use of carotenoids and or carotenoid derivatives analogs for reduction/inhibition of certain negative effects of COX inhibitors. (US20080293679), Patent.

Takahashi, J., Yamashita, E., Fukamauchi, M., and Tanka, I. (2009). Composition for body fat reduction. (US20090047304), Patent.

Sharoni, Y., Levy, J., Sela, Y., and Nir, Z. (2009). Carotenoid oxidation products as chemo preventive and chemotherapeutic agents. (US20090069417), Patent.

Senin, P., Setnikar, I., and Rovati, A. (2009). Formulation for oral administration with beneficial effects on the cardiovascular system. (20090136469), U.S. Patent.

David, A.E., and Melchior, R. (2009). Algal and algal extract dietary supplement composition. (US20090142431), Patent.

Satoh, A., and Tsuji, S. (2009). Method for improving cognitive performance. (US20090297492), Patent.

Qvyjt, F. (2010). Encapsulates. (US20100158984), Patent.

Tominaga, K., Karato, M., Hongo, N., and Yamashita, E. (2010). Method of preventing discoloration of carotenoid pigment and container used therefor. (US20100204523), Patent.

Kopsel, C. (2010). Pulverulent carotenoid preparation for colouring drinks. (US20100267838), Patent.

Clayton, D., and Rutter, R. (2010). Inflammatory disease treatment. (US20100291053), Patent.

Higashi, N., and Takahashi, J. (2012). Agent for alleviating vascular failure. (US20120004297), Patent.

Koppe, W.M., Moeller, N.P., and Baardsen, G.K.L. (2012). Feed additive for improved pigment retention. (US20120114823), Patent.

Jouni, Z., and Makhoul, Z. (2012). Carotenoid containing compositions and methods. (US20120238522), Patent.

Monahan, P., and Hiu, S. (2012). Agent for improving carcass performance in finishing hogs. (US20120253078), Patent.

Minatelli, J.A., Thomas, S., Rajendran, L., and Moerck, E. (2013). Composition and method to alleviate joint pain. (US20130004582), Patent.

Ooi, Y., Kitamura, A., and Yamashita, E. (2013). Baked food produced from astaxanthin containing dough. (US 20130108764), Patent.