Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

Hasin, 2005, Epidemiology of major depressive disorder: results from the national epidemiologic survey on alcoholism and related conditions., Arch Gen Psychiatry, 62, 1097, 10.1001/archpsyc.62.10.1097

Glassman, 1998, Depression and the course of coronary artery disease., Am J Psychiatry, 155, 4, 10.1176/ajp.155.1.4

Musselman, 1998, The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment., Arch Gen Psychiatry, 55, 580, 10.1001/archpsyc.55.7.580

Hemingway, 1999, Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies., BMJ, 318, 1460, 10.1136/bmj.318.7196.1460

Carney, 1988, Major depressive disorder predicts cardiac events in patients with coronary artery disease., Psychosom Med, 50, 627, 10.1097/00006842-198811000-00009

Barefoot, 1996, Symptoms of depression, acute myocardial infarction, and total mortality in a community sample., Circulation, 93, 1976, 10.1161/01.CIR.93.11.1976

Suls, 2005, Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions., Psychol Bull, 131, 260, 10.1037/0033-2909.131.2.260

McDaniel, 1995, Depression in patients with cancer. Diagnosis, biology, and treatment., Arch Gen Psychiatry, 52, 89, 10.1001/archpsyc.1995.03950140007002

Raison, 2003, Depression in cancer: new developments regarding diagnosis and treatment., Biol Psychiatry, 54, 283, 10.1016/S0006-3223(03)00413-X

Spiegel, 2003, Depression and cancer: mechanisms and disease progression., Biol Psychiatry, 54, 269, 10.1016/S0006-3223(03)00566-3

Smith, 1991, The macrophage theory of depression., Med Hypotheses, 35, 298, 10.1016/0306-9877(91)90272-Z

Maier, 1998, Cytokines for psychologists: implications for bidirectional immune-to-brain communication for understanding behavior, mood, and cognition., Psychol Rev, 105, 83, 10.1037/0033-295X.105.1.83

Pearson, 2003, Markers of inflammation and cardiovascular disease., Circulation, 107, 499, 10.1161/01.CIR.0000052939.59093.45

Torzewski, 1998, C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries., Arterioscler Thromb Vasc Biol, 18, 1386, 10.1161/01.ATV.18.9.1386

Paul, 2004, C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice., Circulation, 109, 647, 10.1161/01.CIR.0000114526.50618.24

Clearfield, 2005, C-reactive protein: a new risk assessment tool for cardiovascular disease., J Am Osteopath Assoc, 105, 409

Young, 1991, C-reactive protein: a critical review., Pathology, 23, 118, 10.3109/00313029109060809

Gabay, 1999, Acute-phase proteins and other systemic responses to inflammation., N Engl J Med, 340, 448, 10.1056/NEJM199902113400607

Du Clos, 2000, Function of C-reactive protein., Ann Med, 32, 274, 10.3109/07853890009011772

Goldsby, 2003, Immunology. 5th ed.

Hodge, 2005, The role of IL-6 and STAT3 in inflammation and cancer., Eur J Cancer, 41, 2502, 10.1016/j.ejca.2005.08.016

Nilsson, 2005, Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine., Cancer Res, 23, 10794, 10.1158/0008-5472.CAN-05-0623

Herbert, 1993, Depression and immunity: a meta-analytic review., Psychol Bull, 113, 472, 10.1037/0033-2909.113.3.472

Zorrilla, 2001, The relationship of depression and stressors to immunological assays: a meta-analytic review., Brain Behav Immun, 15, 199, 10.1006/brbi.2000.0597

Kuo, 2005, Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis., Lancet Neurol, 4, 371, 10.1016/S1474-4422(05)70099-5

Mohamed-Ali, 1997, Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo., J Clin Endocrinol Metab, 82, 4196

Yudkin, 2000, Inflammation, obesity, stress, and coronary heart disease: is interleukin-6 the link?, Atherosclerosis, 148, 209, 10.1016/S0021-9150(99)00463-3

Castanon, 2002, Effects of antidepressants on cytokine production and actions., Brain Behav Immun, 16, 569, 10.1016/S0889-1591(02)00008-9

Szeleyni, 2002, Immunomodulatory effects of anti-depressants., Curr Opin Pharmacol, 4, 428, 10.1016/S1471-4892(02)00173-X

Arnaud, 2005, Toward immunomodulatory and anti-inflammatory properties of statins., Trends Cardiovasc Med, 15, 202, 10.1016/j.tcm.2005.07.002

Ridker, 1999, Long-term effects of pravastatin on plasma concentration of C-reactive protein., Circulation, 100, 230, 10.1161/01.CIR.100.3.230

Jilma, 1997, Menstrual cycle-associated changes in blood levels of interleukin-6, alpha 1 acid glycoprotein, and C-reactive protein., J Lab Clin Med, 130, 69, 10.1016/S0022-2143(97)90060-3

Blazer, 1993, Depression in Late Life. 2nd ed.

Cohen, 1997, The association of plasma IL-6 levels with functional disability in community-dwelling elderly., J Gerontol A Biol Sci Med Sci, 52, M201, 10.1093/gerona/52A.4.M201

Lennard, 1995, Interleukin-1 receptor antagonist., Crit Rev Immunol, 15, 77, 10.1615/CritRevImmunol.v15.i1.30

1994, Diagnostic and Statistical Manual of Mental Disorders IV (DSM IV).

Beck, 1988, Psychometric properties of the Beck depression inventory: twenty-five years of evaluation., Clin Psychol Rev, 8, 77, 10.1016/0272-7358(88)90050-5

Cyranowski, 2007, Depressive symptoms and production of proinflammatory cytokines by peripheral blood mononuclear cells stimulated in vitro., Brain Behav Immun, 229, 10.1016/j.bbi.2006.07.005

Levine, 1999, Cerebrospinal cytokine levels in patients with acute depression., Neuropsychobiology, 40, 171, 10.1159/000026615

Sjögren, 2006, Interleukin-6 levels in relation to psychosocial factors: studies on serum, saliva, and in vitro production by blood mononuclear cells., Brain Behav Immun, 20, 270, 10.1016/j.bbi.2005.08.001

Bower, 2007, Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids., Brain Behav Immun, 21, 251, 10.1016/j.bbi.2006.08.001

1989, Current Protocols in Immunology.

Davis, 2008, Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue., Brain Behav Immun, 22, 24, 10.1016/j.bbi.2007.06.013

Frick, 1995, Accepting the null hypothesis., Mem Cognit, 23, 132, 10.3758/BF03210562

Mervis, 2003, Language Competence Across Populations: Toward a Definition of Specific Language Impairment.

Bornstein, 1999, Comprehensive Meta-Analysis: A Computer Program for Research Synthesis.

Hedges, 1985, Statistical Methods for Meta-Analysis.

Hedges, 1998, Fixed- and random-effects models in meta-analysis., Psychol Methods, 3, 486, 10.1037/1082-989X.3.4.486

Egger, 1997, Meta-analysis: principles and procedures., BMJ, 315, 1610, 10.1136/bmj.315.7121.1533

Rosenthal, 1979, The “file drawer problem” and tolerance for null results., Psychol Bull, 86, 638, 10.1037/0033-2909.86.3.638

Berk, 1997, Acute phase proteins in major depression., J Psychosom Res, 43, 529, 10.1016/S0022-3999(97)00139-6

Vetta, 2001, Tumor necrosis factor-α and mood disorders in the elderly., Arch Gerontol Geriatr, 33, 435, 10.1016/S0167-4943(01)00171-6

Radloff, 1977, The CES-D scale: a self-report depression scale for research in the general population., Appl Psychol Meas, 1, 385, 10.1177/014662167700100306

Spitzer, 1999, Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire., JAMA, 282, 1737, 10.1001/jama.282.18.1737

Ershler, 1993, Interleukin-6: a cytokine for gerontologists., J Am Geriatr Soc, 41, 176, 10.1111/j.1532-5415.1993.tb02054.x

Sapolsky, 1986, The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis., Endocr Rev, 7, 284, 10.1210/edrv-7-3-284

Di Gregorio, 2005, Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone., Diabetes, 54, 2305, 10.2337/diabetes.54.8.2305

Guzik, 2006, Adipocytokines—novel link between inflammation and vascular function?, J Physiol Pharmacol, 57, 505

Miller, 2002, Clinical depression and inflammatory risk markers for coronary heart disease., Am J Cardiol, 90, 1279, 10.1016/S0002-9149(02)02863-1

Miller, 2003, Pathways linking depression, adiposity, and inflammatory markers in healthy young adults., Brain Behav Immun, 17, 276, 10.1016/S0889-1591(03)00057-6

Thakore, 1997, Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography., Biol Psychiatry, 41, 1140, 10.1016/S0006-3223(97)85394-2

Jequier, 2002, Leptin signaling, adiposity, and energy balance., Ann N Y Acad Sci, 967, 379, 10.1111/j.1749-6632.2002.tb04293.x

Ladwig, 2003, Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men., Brain Behav Immun, 17, 268, 10.1016/S0889-1591(03)00056-4

Danner, 2003, Association between depression and elevated C-reactive protein., Psychcosom Med, 65, 347, 10.1097/01.PSY.0000041542.29808.01

Janszky, 2005, Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease., Brain Behav Immun, 19, 555, 10.1016/j.bbi.2005.01.001

Empana, 2005, Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men., Circulation, 111, 2299, 10.1161/01.CIR.0000164203.54111.AE

Angstwurm, 1997, Cyclic plasma IL-6 levels during normal menstrual cycle., Cytokine, 9, 370, 10.1006/cyto.1996.0178

Dreon, 2003, Oral contraceptive use and increased plasma concentration of C-reactive protein., Life Sci, 73, 1245, 10.1016/S0024-3205(03)00425-9

Salkeld, 2001, Modulation of body temperature, interleukin-6, and leptin by oral contraceptive use., Neuroimmunomodulation, 9, 319, 10.1159/000059389

Cushman, 1999, Effect of postmenopausal hormones on inflammation-sensitive proteins: the postmenopausal estrogen/progestin interventions (PEPI) study., Circulation, 100, 717, 10.1161/01.CIR.100.7.717

Kop, 2005, The role of immune system parameters in the relationship between depression and coronary artery disease., Psychosom Med, 67, S37, 10.1097/01.psy.0000162256.18710.4a

Dantzer, 2008, From inflammation to sickness and depression: when the immune system subjugates the brain., Nat Rev Neurosci, 9, 46, 10.1038/nrn2297

Yirmiya, 1996, Endotoxin produces a depressive-like episode in rats., Brain Res, 711, 163, 10.1016/0006-8993(95)01415-2

Dantzer, 2001, Cytokine-induced sickness behavior: where do we stand?, Brain Behav Immun, 15, 7, 10.1006/brbi.2000.0613

Meyers, 1999, Mood and cognitive disorders in cancer patients receiving cytokine therapy., Adv Exp Med Biol, 461, 75, 10.1007/978-0-585-37970-8_5

Miyaoka, 1999, Depression from interferon therapy in patients with hepatitis C., Am J Psychiatry, 156, 1120, 10.1176/ajp.156.7.1120

van den Biggelaar, 2007, Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age., Exp Gerontol, 42, 693, 10.1016/j.exger.2007.01.011

Penninx, 2003, Inflammatory markers and depressed mood in older persons: results from the health, aging, and body composition study., Biol Psychiatry, 54, 566, 10.1016/S0006-3223(02)01811-5

Kiecolt-Glaser, 2002, Depression and immune function: central pathways to morbidity and mortality., J Psychosom Res, 53, 873, 10.1016/S0022-3999(02)00309-4

Capuron, 2004, Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy., Brain Behav Immun, 18, 205, 10.1016/j.bbi.2003.11.004

Hopkins, 2003, The pathophysiological role of cytokines., Leg Med, 5, S45, 10.1016/S1344-6223(02)00088-3

Miller, 1997, Sites of action of IL-1 in the development of fever and cytokine responses to tissue inflammation in the rat., Br J Pharmacol, 120, 1274, 10.1038/sj.bjp.0701049

Van Snick, 1990, Interleukin-6: an overview., Annu Rev Immunol, 8, 253, 10.1146/annurev.iy.08.040190.001345

Dinarello, 1991, Interleukin-1 and interleukin-1 antagonism., Blood, 77, 1627, 10.1182/blood.V77.8.1627.1627

Alesci, 2005, Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications., J Clin Endocrinol Metab, 90, 2522, 10.1210/jc.2004-1667

Ai, 2005, Effects of mood state and psychosocial functioning on plasma interleukin-6 in adult patients before cardiac surgery., Int J Psychiatry Med, 35, 363, 10.2190/2ELG-RDUN-X6TU-FGC8

Allen-Mersh, 1998, Relation between depression and circulating immune products in patients with advanced colorectal cancer., J R Soc Med, 91, 408, 10.1177/014107689809100803

Almeida, 2007, The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the health in men study (HIMS)., Psychol Med, 37, 1775, 10.1017/S0033291707000827

Andrei, 2007, Major depressive disorder and inflammatory markers in elderly patients with heart failure., Psychosomatics, 48, 319, 10.1176/appi.psy.48.4.319

Arai, 2006, Usefulness of measuring serum markers in addition to comprehensive geriatric assessment for cognitive impairment and depressed mood in the elderly., Geriatr Gerontol Int, 6, 7, 10.1111/j.1447-0594.2006.00327.x

Basterzi, 2005, IL-6 levels decrease with SSRI treatment in patients with major depression., Human Psychopharm, 20, 473, 10.1002/hup.717

Brambilla, 1998, Blood levels of cytokines in elderly patients with major depressive disorder., Acta Psychiatr Scand, 97, 309, 10.1111/j.1600-0447.1998.tb10005.x

Bremmer, 2008, Inflammatory markers in late-life depression: results from a population-based study., J Affect Disord, 106, 249, 10.1016/j.jad.2007.07.002

Costanzo, 2005, Psychosocial factors and interleukin-6 among women with advanced ovarian cancer., Cancer, 104, 305, 10.1002/cncr.21147

Douglas, 2004, Relationship between depression and C-reactive protein in a screening population., Psychosom Med, 66, 679, 10.1097/01.psy.0000138132.66332.85

Dressler, 2006, Depressive symptoms and C-reactive protein in a Brazilian urban community., Braz J Med Biol Res, 39, 1013, 10.1590/S0100-879X2006000800003

Elovainio, 2006, Depressive symptoms and C-reactive protein: the cardiovascular risk in young Finns study., Psychol Med, 36, 797, 10.1017/S0033291706007574

Eskandari, 2007, Low bone mass in premenopausal women with depression., Arch Intern Med, 167, 2329, 10.1001/archinte.167.21.2329

Ferketich, 2005, Depressive symptoms and inflammation among heart failure patients., Am Heart J, 150, 132, 10.1016/j.ahj.2004.08.029

Ferrucci, 2002, Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels., J Am Geriatr Soc, 50, 1947, 10.1046/j.1532-5415.2002.50605.x

Frommberger, 1997, Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission., Eur Arch Psychiatry Clin Neuroscience, 247, 228, 10.1007/BF02900219

Glaser, 2003, Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults., Arch Gen Psychiatry, 60, 1009, 10.1001/archpsyc.60.10.1009

Haack, 1999, Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis., J Psychiatr Res, 33, 407, 10.1016/S0022-3956(99)00021-7

Häfner, 2008, C-reactive protein is associated with polymorphisms of the angiotensin-converting enzyme in major depressed patients., J Psychiatr Res, 42, 163, 10.1016/j.jpsychires.2007.02.002

Hekler, 2007, Inflammatory markers in acute myocardial infarction patients: preliminary evidence of a prospective association with depressive symptoms., J Appl Biobehav Res, 12, 65, 10.1111/j.1751-9861.2007.00014.x

Hemingway, 2003, Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II study)., Am J Cardiol, 92, 984, 10.1016/S0002-9149(03)00985-8

Hornig, 1998, Positive and negative acute phase proteins in affective subtypes., J Affective Disorders, 49, 9, 10.1016/S0165-0327(97)00180-8

Huang, 2007, T-helper1/T-helper 2 cytokine imbalance and clinical phentoypes of acute-phase major depression., Psychiatry Clin Neurosci, 61, 415, 10.1111/j.1440-1819.2007.01686.x

Huang, 2007, High-sensitivity C-reactive protein levels in patients with major depressive disorder and bipolar mania., Prog Neuro-Psychopharmacol Biol Psychiatry, 31, 370, 10.1016/j.pnpbp.2006.09.010

Hung, 2007, Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder., Clin Endocrinol, 67, 784, 10.1111/j.1365-2265.2007.02963.x

Jacobson, 2008, Depression and IL-6 blood plasma concentrations in advanced cancer patients., Psychsomatics, 49, 64, 10.1176/appi.psy.49.1.64

Janszky, 2005, Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease., Brain Behav Immun, 19, 555, 10.1016/j.bbi.2005.01.001

Jehn, 2006, Biomarkers of depression in cancer patients., Cancer, 107, 2723, 10.1002/cncr.22294

Joyce, 1992, Elevated levels of acute phase plasma proteins in major depression., Biol Psychiatry, 32, 1035, 10.1016/0006-3223(92)90065-8

Kagaya, 2001, Plasma concentrations of interleukin-1β, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor-α of depressed patients in Japan., Neuropsychobiology, 43, 59, 10.1159/000054867

Kahl, 2005, Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder., Psychosom Med, 67, 407, 10.1097/01.psy.0000160458.95955.f4

Kiecolt-Glaser, 2007, Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults., Psychosom Med, 69, 217, 10.1097/PSY.0b013e3180313a45

Kling, 2007, Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A., Biol Psychiatry, 62, 309, 10.1016/j.biopsych.2006.09.033

Koenig, 1997, Attendance at religious services, interleukin-6, and other biological parameters of immune function in older adults., Int J Psychiatry Med, 27, 233, 10.2190/40NF-Q9Y2-0GG7-4WH6

Komulainen, 2007, Serum high sensitivity C-reactive protein and cognitive function in elderly women., Age Ageing, 36, 443, 10.1093/ageing/afm051

Kop, 2002, Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia., Am J Cardiol, 89, 419, 10.1016/S0002-9149(01)02264-0

Kubera, 2000, Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission., Polish J Pharmacol, 52, 237

Kudoh, 2001, Plasma inflammatory cytokine response to surgical trauma in chronic depressed patients., Cytokine, 13, 104, 10.1006/cyto.2000.0802

Lanquillon, 2000, Cytokine production and treatment response in major depressive disorder., Neuropsychopharmacology, 22, 370, 10.1016/S0893-133X(99)00134-7

Leo, 2006, Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy., J Clin Psychiatry, 67, 1760, 10.4088/JCP.v67n1114

Lespérance, 2004, The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes., Am J Psychiatry, 161, 271, 10.1176/appi.ajp.161.2.271

Liukkonen, 2006, The association between C-reactive protein levels and depression: results from the Northern Finland 1966 Birth Cohort Study., Biol Psychiatry, 60, 825, 10.1016/j.biopsych.2006.02.016

Loucks, 2006, Relation of social integration to inflammatory marker concentrations in men and women 70 to 79 years., Am J Cardiol, 97, 1010, 10.1016/j.amjcard.2005.10.043

Lutgendorf, 1999, Life stress, mood disturbance, and elevated interleukin-6 in healthy older women., J Gerontol, 54A, M434, 10.1093/gerona/54.9.M434

Lutgendorf, 2004, Religious participation, interleukin-6, and mortality in older adults., Health Psychol, 23, 465, 10.1037/0278-6133.23.5.465

Lyness, 2001, Depression, medical illness, and interleukin-1β in older cardiac patients., Int J Psychiatry Med, 31, 305, 10.2190/0JJ0-4BHW-FM8K-D5RH

Maes, 1997, Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression., Cytokine, 9, 853, 10.1006/cyto.1997.0238

Maes, 1995, Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2, and transferring receptor in major depression., J Affective Disorders, 34, 301, 10.1016/0165-0327(95)00028-L

Maes, 1995, Increased serum interleukin-1 receptor-antagonist concentrations in major depression., J Affect Disord, 36, 29, 10.1016/0165-0327(95)00049-6

McDade, 2006, Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study., Psychosom Med, 68, 376, 10.1097/01.psy.0000221371.43607.64

Melamed, 2004, Association of fear and terror with low-grade inflammation among apparently healthy employed adults., Psychosom Med, 66, 484, 10.1097/01.psy.0000130963.52755.b9

Mikova, 2001, Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis., Eur Neuropsychopharmacol, 11, 203, 10.1016/S0924-977X(01)00081-5

Miller, 2005, Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes., Am J Cardiol, 95, 317, 10.1016/j.amjcard.2004.09.026

Miller, 2005, Clinical depression and regulation of the inflammatory response during acute stress., Psychosom Med, 67, 679, 10.1097/01.psy.0000174172.82428.ce

Moorman, 2007, In patients with heart failure elevated soluble TNF-receptor 1 is associated with higher risk of depression., J Card Fail, 13, 738, 10.1016/j.cardfail.2007.06.301

Motivala, 2005, Inflammatory markers and sleep disturbance in major depression., Psychosom Med, 67, 187, 10.1097/01.psy.0000149259.72488.09

Mussleman, 2001, Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings., Am J Psychiatry, 158, 1252, 10.1176/appi.ajp.158.8.1252

Owen, 2001, Raised levels of plasma interleukin-1β in major and postviral depression., Acta Psychiatr Scand, 103, 226, 10.1034/j.1600-0447.2001.00162.x

Pace, 2006, Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress., Am J Psychiatry, 163, 1630, 10.1176/ajp.2006.163.9.1630

Pan, 2008, The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese., PLoS ONE, 3, e1392, 10.1371/journal.pone.0001392

Panagiotakos, 2004, Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study., Eur Heart J, 25, 492, 10.1016/j.ehj.2004.01.018

Parissis, 2004, Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus with symptoms of depression., Am J Cardiol, 94, 1326, 10.1016/j.amjcard.2004.07.127

Pike, 2006, Dissociation of inflammatory markers of natural killer cell activity in major depressive disorder., Brain Behav Immun, 20, 169, 10.1016/j.bbi.2005.05.004

Ranjit, 2007, Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis., Arch Intern Med, 167, 174, 10.1001/archinte.167.2.174

Rief, 2001, Immunological differences between patients with major depression and somatization syndrome., Psychiatry Res, 105, 165, 10.1016/S0165-1781(01)00338-9

Rothermundt, 2001, Inflammatory markers in major depression and melancholia., J Affect Disord, 63, 93, 10.1016/S0165-0327(00)00157-9

Schins, 2005, Inflammatory markers in depressed post-myocardial infarction patients., J Psychiatric Res, 39, 137, 10.1016/j.jpsychires.2005.04.008

Seidel, 1995, Cytokine production and serum proteins in depression., Scand J Immunol, 41, 534, 10.1111/j.1365-3083.1995.tb03604.x

Shimbo, 2006, Relation between C-reactive protein and depression remission status in patients presenting with acute coronary syndrome., Heart, 92, 1316, 10.1136/hrt.2005.075861

Sluzewska, 1996, Indicators of immune activation in major depression., Psychiatry Res, 64, 161, 10.1016/S0165-1781(96)02783-7

Sluzewska, 1995, Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine., Ann N Y Acad Sci, 762, 474, 10.1111/j.1749-6632.1995.tb32372.x

Song, 1998, The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression., J Affect Disord, 49, 211, 10.1016/S0165-0327(98)00025-1

Soygur, 2007, Interleukin-6 levels and HPA axis activation in breast cancer patients with major depressive disorder., Prog Neuro-Psychopharmacol Biol Psychiatry, 1242, 10.1016/j.pnpbp.2007.05.001

Steptoe, 2003, Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women., Psychol Med, 33, 667, 10.1017/S0033291702007250

Suarez, 2004, C-reactive protein is associated with psychological risk factors of cardiovascular disease in apparently healthy adults., Psychosom Med, 66, 684, 10.1097/01.psy.0000138281.73634.67

Suarez, 2003, Joint effect of hostility and severity of depressive symptoms on plasma interleukin-6 concentration., Psychosom Med, 65, 523, 10.1097/01.PSY.0000062530.94551.EA

Taylor, 2006, Relationship of early life stress and psychological functioning to adult C-reactive protein in the Coronary Artery Risk Development in Young Adults Study., Biol Psychiatry, 60, 819, 10.1016/j.biopsych.2006.03.016

Thomas, 2005, Increase in interleukin-1β in late-life depression., Am J Psychiatry, 162, 175, 10.1176/appi.ajp.162.1.175

Tiemeier, 2003, Inflammatory proteins and depression in the elderly., Epidemiology, 14, 103, 10.1097/00001648-200301000-00025

Toker, 2005, The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women., J Occup Health Psychol, 10, 344, 10.1037/1076-8998.10.4.344

Tuglu, 2003, Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder., Psychopharmacology, 170, 429, 10.1007/s00213-003-1566-z

Vaccarino, 2007, Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia., J Am Coll Cardiol, 50, 2044, 10.1016/j.jacc.2007.07.069

Whooley, 2007, Depression and inflammation in patients with coronary heart disease: findings from the heart and soul study., Biol Psychiatry, 62, 314, 10.1016/j.biopsych.2006.10.016

Yang, 2007, Levels of serum interleukin (IL)-6, IL-1β, tumour necrosis factor-α and leptin and their correlation in depression., Aust N Z J Psychiatry, 41, 266, 10.1080/00048670601057759