Associations between plasma polyunsaturated fatty acids, plasma stearoyl‐CoA desaturase indices and body fat

Obesity - Tập 21 Số 9 - 2013
Kathrine J. Vinknes1, Amany Elshorbagy2,3, Christian A. Drevon1, Eha Nurk1,4, Grethe S. Tell5, Ottar Nygård6,7, Dan J. Stein5,8, Helga Refsum1,2
1Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway
2Department of Pharmacology, University of Oxford, Oxford, UK
3Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
4Department of Surveillance and Evaluation, National Institute for Health Development, Tallinn, Estonia
5Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
6Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
7Section for Cardiology, Institute of Medicine, University of Bergen, Bergen, Norway
8Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

Tóm tắt

ObjectiveStearoyl‐CoA desaturase (SCD)‐1 deficient mice are resistant to obesity and plasma SCD indices are related to obesity in humans. Both n‐3 and n‐6 polyunsaturated fatty acids (PUFA) regulate expression of the SCD enzymes. Whether higher plasma PUFA were associated with lower SCD indices in humans was examined.Design and MethodsPopulation‐based study of 2,021 elderly subjects from the Hordaland Health Study. Using multivariate linear regression, the cross‐sectional associations among plasma PUFA, estimated SCD indices (from fatty acid profiles in plasma total lipids), and fat mass measured by dual‐energy X‐ray absorptiometry were explored. Two plasma SCD indices were used: SCD‐16 (16:1n‐7/16:0) and SCD‐18 (18:1n‐9/18:0).ResultsPlasma total, n‐6 and n‐3 PUFA were inversely associated with both SCD indices (P < 0.001 for all). Among the individual PUFA, 18:2n‐6 showed the strongest association with SCD‐16 (partial r = −0.59, P < 0.001) followed by 20:5n‐3 (partial r = −0.13; P < 0.001). Plasma total, n‐6 and n‐3 PUFA were inversely associated with body fat (P < 0.001 for all); the associations were markedly attenuated following adjustment for SCD‐16.ConclusionsThe epidemiological data are in line with animal studies and suggest that PUFA may decrease SCD1 activity in humans, with possible reduction in body fat.

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Obesity

Tập 21 Số 9

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