Mối liên hệ giữa chức năng nội mạc mạch máu và chất lượng cuộc sống ở bệnh nhân thiếu máu cục bộ và bệnh động mạch vành không tắc nghẽn

Keling Xiao1, Machao Liu2, Xipeng Sun2, Yinghua Zhang1, Jin Si1, Ning Shi1, Lijie Sun1, Zupei Miao1, Haoyu Zhang1, Ting Zhao1, Zhi Liu2, Zhenxing Fan2, Jing Gao2, Jing Li1
1Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China
2Division of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China

Tóm tắt

Cần cải thiện chất lượng cuộc sống (QoL) của bệnh nhân bị thiếu máu cục bộ và bệnh động mạch vành không tắc nghẽn (INOCA). Nhiều bệnh nhân INOCA trải qua rối loạn chức năng nội mạc mạch. Tuy nhiên, mối liên hệ giữa chức năng nội mạc và QoL vẫn chưa được làm sáng tỏ. Nghiên cứu này nhằm điều tra ban đầu mối liên hệ giữa chức năng nội mạc và QoL ở bệnh nhân INOCA. Nghiên cứu quan sát tiến cứu này bao gồm 121 bệnh nhân INOCA (tuổi từ 31-85). Chức năng nội mạc mạch được đánh giá thông qua phương pháp giãn mạch trung gian dòng chảy (FMD) của động mạch cánh tay ngoại vi. QoL được đánh giá bằng Bảng hỏi sức khỏe ngắn 36 mục (SF-36). Bệnh nhân INOCA được chia thành hai nhóm dựa trên thay đổi FMD trung vị trong thời gian theo dõi 1 năm (nhóm A, ≥ ngưỡng thay đổi FMD trung vị; nhóm B, < ngưỡng thay đổi FMD trung vị). Thay đổi FMD trung vị là 0,92%. Điểm SF-36 cơ bản trung bình tương đương giữa hai nhóm (53,95 ± 6,46 so với 53,92 ± 4,29, p = 0,98). QoL tại lần theo dõi tốt hơn ở nhóm A so với nhóm B (56,61 ± 5,50 so với 53,32 ± 5,58, p = 0,002). Thay đổi FMD (r = 0,34, p < 0,01), thay vì FMD tại cơ bản (r = −0,01, p = 0,89) hoặc theo dõi (r = 0,13, p = 0,15), có liên quan đến điểm SF-36 tại theo dõi. Cải thiện FMD là một yếu tố dự đoán độc lập cho việc tăng QoL (tỷ lệ odds, 3,90; khoảng tin cậy 95%: 1,59–9,53, p = 0,003). Thay đổi chức năng nội mạc có liên quan đến QoL, và bệnh nhân có cải thiện chức năng nội mạc có QoL tốt hơn so với những người không có.

Từ khóa

#chức năng nội mạc mạch #chất lượng cuộc sống #thiếu máu cục bộ #bệnh động mạch vành không tắc nghẽn #giãn mạch trung gian dòng chảy #SF-36

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