Association of the PTPN22 gene (+1858C/T, −1123G/C) polymorphisms with type 1 diabetes mellitus: A systematic review and meta-analysis

Notokins, 2001, Autoimmune type 1 diabetes: resolved and unresolved, J Clin Invest, 108, 1247, 10.1172/JCI200114257 Hirschhorn, 2003, Genetic epidemiology of type 1 diabetes, Pediatr Diabetes, 4, 87, 10.1034/j.1399-5448.2001.00013.x Nerup, 1974, HL-A antigens and diabetes mellitus, Lancet, 2, 864, 10.1016/S0140-6736(74)91201-X Bell, 1984, A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus, Diabetes, 33, 176, 10.2337/diabetes.33.2.176 Kristiansen, 2000, CTLA-4 in autoimmune diseases—a general susceptibility gene to autoimmunity?, Genes Immun, 1, 170, 10.1038/sj.gene.6363655 Onengut-Gumuscu, 2004, A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families, Genes Immun, 5, 678, 10.1038/sj.gene.6364138 Cloutier, 1999, Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase, J Exp Med, 189, 111, 10.1084/jem.189.1.111 Wilkin, 2001, The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes, Diabetologia, 44, 914, 10.1007/s001250100548 van Oene, 2005, Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations, Arthritis Rheum, 52, 1993, 10.1002/art.21123 Orozco, 2005, Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus, Arthritis Rheum, 52, 219, 10.1002/art.20771 Skórka, 2005, Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves’ disease in a Polish population: association and gene dose-dependent correlation with age of onset, Clin Endocrinol (Oxf), 62, 679, 10.1111/j.1365-2265.2005.02279.x Chelala, 2007, PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits, Diabetes, 56, 522, 10.2337/db06-0942 Fichna, 2010, PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients, Int J Immunogenet, 37, 367, 10.1111/j.1744-313X.2010.00935.x Cinek, 2007, No independent role of the −1123 G>C and +2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations, Diabetes Res Clin Pract, 76, 297, 10.1016/j.diabres.2006.09.009 Liu, 2011, The −1123G>C variant of PTPN22 gene promoter is associated with latent autoimmune diabetes in adult Chinese Hans, Cell Biochem Biophys Kawasaki, 2006, Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations, Am J Med Genet A, 140, 586, 10.1002/ajmg.a.31124 Chagastelles, 2010, Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population, Tissue Antigens, 76, 144 Zhebrun, 2011, Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves’ disease but not with rheumatoid arthritis in Russian population, Aging (Albany NY), 3, 368, 10.18632/aging.100305 Korolija, 2009, Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians, Diabetes Res Clin Pract, 86, 54, 10.1016/j.diabres.2009.09.012 Lavrikova, 2009, Association of the C1858T polymorphism of the PTPN22 gene with type 1 diabetes, Mol Biol (Mosk), 43, 1040, 10.1134/S0026893309060089 Steck, 2006, Association of the PTPN22/LYP gene with type 1 diabetes, Pediatr Diabetes, 7, 274, 10.1111/j.1399-5448.2006.00202.x Zheng, 2005, Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes, Diabetes, 54, 906, 10.2337/diabetes.54.3.906 Baniasadi, 2008, No evidence for association of PTPN22 R620W functional variant C1858T with type 1 diabetes in Asian Indians, J Cell Mol Med, 12, 1061, 10.1111/j.1582-4934.2008.00222.x Douroudis, 2008, Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population, Tissue Antigens, 72, 425, 10.1111/j.1399-0039.2008.01115.x Gomez, 2005, PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases, Genes Immun, 6, 628, 10.1038/sj.gene.6364261 Smyth, 2004, Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus, Diabetes, 53, 3020, 10.2337/diabetes.53.11.3020 Santiago, 2007, Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population, BMC Med Genet, 13, 54, 10.1186/1471-2350-8-54 Fedetz, 2006, The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population, Tissue Antigens, 67, 430, 10.1111/j.1399-0039.2006.00591.x Dultz, 2009, The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes, Thyroid, 19, 143, 10.1089/thy.2008.0301 Kahles, 2005, Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population, Eur J Endocrinol, 153, 895, 10.1530/eje.1.02035 Zhernakova, 2005, Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population, Genes Immun, 6, 459, 10.1038/sj.gene.6364220 Bottini, 2004, A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes, Nat Genet, 36, 337, 10.1038/ng1323 Petrone, 2008, The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3, Diabetes Care, 31, 534, 10.2337/dc07-1457 Kordonouri, 2010, PTPN22 1858T allele is associated with younger age at onset of type 1 diabetes and is not related to subsequent thyroid autoimmunity, Hum Immunol, 71, 731, 10.1016/j.humimm.2010.04.002 Guo, 1992, Performing the exact test of Hardy–Weinberg proportion for multiple alleles, Biometrics, 48, 361, 10.2307/2532296 Cleves, 1999, Hardy–Weinberg equilibrium test and allele frequency estimation, Stata Tech Bull, 48, 34 Cui, 2000, Hardy–Weinberg equilibrium test in case–control studies, Stata Tech Bull, 57, 17 Thakkinstian, 2005, A method for meta-analysis of molecular association studies, Stat Med, 24, 1291, 10.1002/sim.2010 Begg, 1994, Operating characteristics of a rank correlation test for publication bias, Biometrics, 50, 1088, 10.2307/2533446 Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ, 315, 629, 10.1136/bmj.315.7109.629 Xu, 2010, ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case–control studies, Prostate Cancer Prostatic Dis, 13, 270, 10.1038/pcan.2010.6 Lee, 2007, The PTPN22 C1858T functional polymorphism and autoimmune diseases—a meta-analysis, Rheumatology, 46, 49, 10.1093/rheumatology/kel170