Mối liên hệ giữa α-tocopherol huyết thanh với hormone steroid giới tính và tương tác với việc hút thuốc: Ý nghĩa đối với nguy cơ ung thư tuyến tiền liệt

Cancer Causes & Control - Tập 22 - Trang 827-836 - 2011
Alison M. Mondul1,2, Sabine Rohrmann3, Andy Menke4,5, Manning Feinleib4, William G. Nelson6,7,8,9,10, Elizabeth A. Platz4,9,10, Demetrius Albanes1
1Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, USA
2Rockville, USA
3Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;
5Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, USA
6Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, USA
7Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, USA
8Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, USA
9The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, USA
10The Brady Urological Research Institute, The Johns Hopkins University School of Medicine, Baltimore, USA

Tóm tắt

Vitamin E có thể có tác dụng bảo vệ chống lại ung thư tuyến tiền liệt, có thể chỉ ở những người hút thuốc và, theo giả thuyết của chúng tôi, thông qua sự thay đổi hormone steroid giới tính. Một thử nghiệm có kiểm soát trên những người hút thuốc cho thấy rằng mức hormone giới tính có mối tương quan nghịch với α-tocopherol huyết thanh ban đầu và giảm trong phản ứng với việc bổ sung vitamin E. Mối quan hệ giữa vitamin E và hormone chưa được nghiên cứu nhiều ở những người không hút thuốc. Mức hormone steroid giới tính và α-tocopherol đã được đo ở 1.457 nam giới trong nghiên cứu NHANES III. Nồng độ hormone trung bình đã điều chỉnh đa biến theo từng nhóm α-tocopherol được ước lượng. Chúng tôi quan sát thấy nồng độ testosterone, estradiol và SHBG trung bình giảm khi mức α-tocopherol huyết thanh tăng lên (Q1 = 5.5 và Q5 = 4.6 ng/ml, p-trend = 0.0007; Q1 = 37.8 và Q5 = 33.1 pg/ml, p-trend = 0.02; Q1 = 38.8 và Q5 = 30.6 pg/ml, p-trend = 0.05, tương ứng). Các tương tác giữa α-tocopherol huyết thanh và việc tiếp xúc với khói thuốc lá đối với testosterone tổng, estradiol tổng và SHBG được tìm thấy với mối quan hệ nghịch chỉ được quan sát ở những người hút thuốc. Kết quả từ nghiên cứu cắt ngang đại diện quốc gia này chỉ ra một mối liên hệ nghịch giữa α-tocopherol huyết thanh và testosterone, estradiol và SHBG lưu hành, nhưng chỉ ở những nam giới hút thuốc. Các phát hiện của chúng tôi hỗ trợ vitamin E có ảnh hưởng chọn lọc đến hormone giới tính ở những người hút thuốc và cung cấp các cơ chế khả thi thông qua đó vitamin E có thể tác động đến nguy cơ ung thư tuyến tiền liệt.

Từ khóa

#Vitamin E #α-tocopherol #hormone steroid giới tính #hút thuốc #ung thư tuyến tiền liệt

Tài liệu tham khảo

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