Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults: The FIT-AGEING study

López-Otín, 2013, The hallmarks of aging, Cell, 153, 10.1016/j.cell.2013.05.039 Sen, 2016, Epigenetic mechanisms regulating longevity and aging, Cell, 166, 822, 10.1016/j.cell.2016.07.050 Jin, 2015, The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population, Aging Dis., 6, 1 Fulop, 2010, Aging, frailty and age-related diseases, Biogerontology, 11, 547, 10.1007/s10522-010-9287-2 Gruber, 2017, Approaches for extending human healthspan: from antioxidants to healthspan pharmacology, Essays Biochem., 61, 389, 10.1042/EBC20160091 Crogan, 2017, Nutritional problems affecting older adults, Nurs. Clin. North Am., 52, 433, 10.1016/j.cnur.2017.04.005 Rebelo-Marques, 2018, Aging hallmarks: the benefits of physical exercise, Front. Endocrinol. (Lausanne), 9, 1, 10.3389/fendo.2018.00258 Pedersen, 2015, Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases, Scand. J. Med. Sci. Sport., 25, 1, 10.1111/sms.12581 Gremeaux, 2012, Exercise and longevity, Maturitas, 73, 312, 10.1016/j.maturitas.2012.09.012 Ekblom-Bak, 2014, The importance of non-exercise physical activity for cardiovascular health and longevity, Br. J. Sports Med., 48, 233, 10.1136/bjsports-2012-092038 Arem, 2015, Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship, JAMA Intern. Med., 175, 959, 10.1001/jamainternmed.2015.0533 Lee, 2012, Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy, Lancet, 380, 219, 10.1016/S0140-6736(12)61031-9 Patterson, 2018, Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis, Eur. J. Epidemiol., 1, 1 Amaro Gahete, 2017, Fitness assessment as an anti-aging marker: a narrative review, J. Gerontol. Geriatr. Res., 06, 10.4172/2167-7182.1000455 Castillo-Garzón, 2006, Anti-aging therapy through fitness enhancement, Clin. Interv. Aging, 1, 213, 10.2147/ciia.2006.1.3.213 García-Hermoso, 2018, Muscular strength as a predictor of all-cause mortality in an apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women, Arch. Phys. Med. Rehabil., 10.1016/j.apmr.2018.01.008 Volaklis, 2015, Muscular strength as a strong predictor of mortality: a narrative review, Eur. J. Intern. Med., 26, 303, 10.1016/j.ejim.2015.04.013 Lee, 2010, Mortality trends in the general population: the importance of cardiorespiratory fitness, J. Psychopharmacol., 24, 27, 10.1177/1359786810382057 Harber, 2017, Impact of cardiorespiratory fitness on all-cause and disease-specific mortality: advances since 2009, Prog. Cardiovasc. Dis., 10.1016/j.pcad.2017.03.001 Fitzgerald, 2004, Muscular fitness and all-cause mortality: prospective observations, J. Phys. Act. Heal., 1, 7, 10.1123/jpah.1.1.7 Kuro-o, 1997, Mutation of the mouse klotho gene leads to a syndrome resembling ageing, Nature, 390, 45, 10.1038/36285 Iida, 2011, Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging, Mol. Cell. Biochem., 348, 89, 10.1007/s11010-010-0642-z Saito, 1998, Klotho protein protects against endothelial dysfunction, Biochem. Biophys. Res. Commun., 248, 324, 10.1006/bbrc.1998.8943 Kuro-o, 2010, Arch. Eur. J. Physiol., 459, 333, 10.1007/s00424-009-0722-7 Kim, 2015, Biological role of anti-aging protein Klotho, J. Lifestyle Med., 5, 1, 10.15280/jlm.2015.5.1.1 Imura, 2004, Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane, FEBS Lett., 565, 143, 10.1016/j.febslet.2004.03.090 Bloch, 2009, Klotho is a substrate for alpha-, beta- and gamma-secretase, FEBS Lett., 583, 3221, 10.1016/j.febslet.2009.09.009 Chang, 2005, The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel, Science, 310, 490, 10.1126/science.1114245 Chen, 2007, Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17, PNAS, 104, 19796, 10.1073/pnas.0709805104 Semba, 2011, Plasma klotho and cardiovascular disease in adults, J. Am. Geriatr. Soc., 59, 1596, 10.1111/j.1532-5415.2011.03558.x Semba, 2011, Plasma klotho and mortality risk in older community-dwelling adults, J. Gerontol. - Ser. A Biol. Sci. Med. Sci., 66, 794, 10.1093/gerona/glr058 Tan, 2018, High-intensity physical exercise increases serum α -klotho levels in healthy volunteers, J. Circ. Biomark., 7, 10.1177/1849454418794582 Mostafidi, 2016, Serum klotho levels in trained athletes, Nephrourol. Mon., 8, 10.5812/numonthly.30245 Matsubara, 2014, Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women, Am. J. Physiol. Hear. Circ. Physiol., 306, 348, 10.1152/ajpheart.00429.2013 Phelps, 2013, Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice, Biogerontology, 14, 729, 10.1007/s10522-013-9447-2 Semba, 2016, Health ABC study, low plasma klotho concentrations and decline of knee strength in older adults, J. Gerontol. A Biol. Sci. Med. Sci., 71, 103, 10.1093/gerona/glv077 Semba, 2012, Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study, Eur. J. Appl. Physiol., 112, 1215, 10.1007/s00421-011-2072-3 Belsky, 2015, Quantification of biological aging in young adults, Proc. Natl. Acad. Sci., 112, E4104, 10.1073/pnas.1506264112 Fontana, 2014, Medical research: treat ageing, Nature, 511, 405, 10.1038/511405a F.J. Amaro-Gahete, A. De-la-O, L. Jurado-Fasoli, A. Espuch-Oliver, T. de Haro, A. Gutierrez, J.R. Ruiz, M.J. Castillo, Body composition and S-Klotho plasma levels in middle-aged adults: a cross-sectional study, Rejuvenation Res. (2019) in press, https://doi:10.1089/rej.2018.2092. Migueles, 2017, Accelerometer data collection and processing criteria to assess physical activity and other outcomes: a systematic review and practical considerations, Sport. Med., 47, 1821, 10.1007/s40279-017-0716-0 van Hees, 2014, Autocalibration of accelerometer data for free-living physical activity assessment using local gravity and temperature: an evaluation on four continents, J. Appl. Physiol., 117, 738, 10.1152/japplphysiol.00421.2014 Van Hees, 2015, A novel, open access method to assess sleep duration using a wrist-worn accelerometer, PLoS One, 10, 1, 10.1371/journal.pone.0142533 Hildebrand, 2017, Evaluation of raw acceleration sedentary thresholds in children and adults, Scand. J. Med. Sci. Sport., 27, 1814, 10.1111/sms.12795 Hildebrand, 2014, Age group comparability of raw accelerometer output from wrist-and hip-worn monitors, Med. Sci. Sports Exerc., 46, 1816, 10.1249/MSS.0000000000000289 Balke, 1959, An experimental study of physical fitness of Air Force personnel, U. S. Armed Forces Med. J., 10, 675 Borg, 1982, Psychophysical bases of perceived exertion, Med. Sci. Sports Exerc., 14, 377, 10.1249/00005768-198205000-00012 Midgley, 2007, Criteria for determination of maximal oxygen uptake: a brief critique and recommendations for future research, Sport. Med., 37, 1019, 10.2165/00007256-200737120-00002 Artero, 2012, Effects of whole-body vibration and resistance training on knee extensors muscular performance, Eur. J. Appl. Physiol., 112, 1371, 10.1007/s00421-011-2091-0 Sole, 2007, Test-retest reliability of isokinetic knee extension and flexion, Arch. Phys. Med. Rehabil., 88, 626, 10.1016/j.apmr.2007.02.006 Ruiz-Ruiz, 2002, Hand size influences optimal grip span in women but not in men, J. Hand Surg., 27, 897, 10.1053/jhsu.2002.34315 Crasto, 2012, Relationship of low-circulating “anti-aging” klotho hormone with disability in activities of daily living among older community-dwelling adults, Rejuvenation Res., 5, 295, 10.1089/rej.2011.1268 Amaro-Gahete, 2018, Role of exercise on S-Klotho protein regulation: a systematic review, Curr. Aging Sci., 11 Powers, 2016, Exercise-induced oxidative stress: past, present and future, J. Physiol., 594, 5081, 10.1113/JP270646 Traustadóttir, 2012, Oxidative stress in older adults: effects of physical fitness, Age (Omaha), 34, 969, 10.1007/s11357-011-9277-6 Rosado-Pérez, 2018, Relationship between aerobic capacity with oxidative stress and inflammation biomarkers in the blood of older Mexican urban-dwelling population, Dose-Response, 16, 10.1177/1559325818773000 Zeldich, 2014, The neuroprotective effect of klotho is mediated via regulation of members of the redox system, J. Biol. Chem., 289, 24700, 10.1074/jbc.M114.567321 Yamamoto, 2005, Regulation of oxidative stress by the anti-aging hormone klotho, Biol. Chem., 280, 3829, 10.1074/jbc.M509039200 Kuro-o, 2008, Klotho as a regulator of oxidative stress and senescence, Biol. Chem., 389, 233, 10.1515/BC.2008.028 Bouzid, 2015, Radical oxygen species, exercise and aging: an update, Sport. Med., 45, 1245, 10.1007/s40279-015-0348-1 Avin, 2014, Skeletal muscle as a regulator of the longevity protein, Klotho, Front. Physiol., 5, 1 Liu, 2007, Augmented Wnt signaling in a mammalian model of accelerated aging, Science, 317, 803, 10.1126/science.1143578 Izbeki, 2010, 16, 3101 Fukino, 2002, 293, 332 Doi, 2011, Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice, J. Biol. Chem., 286, 8655, 10.1074/jbc.M110.174037