Association of nonalcoholic fatty liver disease with the different types of dietary carbohydrates: a cross-sectional study

Journal of Diabetes & Metabolic Disorders - Tập 22 - Trang 1139-1143 - 2023
Maryam Afsharfar1, Zahra Salimi2, Bahareh Aminnezhad kavkani3, Soheila Shekari3, Saheb Abbastorki4, Nazanin Majidi3, Maryam Gholamalizadeh5, Alireza Mosavi Jarrahi6, Azadeh Hajipour7, Hanieh Shafaei8, Saeid Doaei9
1Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
8Guilan University of Medical Sciences Shahid Beheshti Nursing and Midwifery School of Rasht, Rasht, Iran
9Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Tóm tắt

Many factors like sedentary lifestyle, metabolic syndrome, and obesity are involved in the increased prevalence of nonalcoholic fatty liver disease (NAFLD). Dietary consumption of carbohydrates may has a role in the risk of NAFLD. This study aimed to investigate the association of NAFLD with the different types of dietary carbohydrates. This cross-sectional study was carried out on 4200 participants including 660 patients with NAFLD and 3540 helathy individuals without NAFLD ages 35 to 70 in sabzevar, Iran. Data on socio-deomgraphic status, anthropomrtric measurments, blood tests, and dietary intake of different types of dietary carbohydrates was collected. The patients with NAFLD had a significantly higher dietary intake of glucose (29.38 ± 18.29 vs. 27.42 ± 15.96 g/d, P = 0.01) and fructose (33.99 ± 20.19 vs. 31.95 ± 18.34 g/d, P = 0.01) compared to the healthy people. A positive association was observed between NAFLD with the total intake of carbohydrates after adjustment for age, sex, and BMI (OR: 1.001, CI 95%: 1-1.002, P = 0.04) The association remained significant after further adjustments for for education level, marital status, physical activity, smoking, and drinking alcohol (Model 2) and after additional adjustments for calorie intake (Model 3). This study showed a positive association between total dietary carbohydrate and NAFLD. In particular, the amount of dietary of carbohydrates (regardless of the type of carbohydrate) may worsen NAFLD. Further longitudinal studies are warranted.

Tài liệu tham khảo

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