Association ofLPAVariants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies

JAMA Cardiology - Tập 3 Số 7 - Trang 619 - 2018
Stephen Burgess1,2, Brian A. Ference3,1,4, James R Staley5,1, Daniel F. Freitag1, Amy M. Mason1, Sune F. Nielsen6,7,8, Peter Willeit9,1, Robin Young10,1, Praveen Surendran1, Savita Karthikeyan1, Thomas R Bolton1, James E. Peters1, Pia R. Kamstrup6,8, Anne Tybjærg‐Hansen11,12,7,8, Marianne Benn12,7,8, Anne Langsted6,8, Peter Schnohr11, Vittorio Krogh6,7,8, Camilla J. Kobylecki6,7,8, Ian Ford10, Chris J. Packard13, Stella Trompet14,15, J. Wouter Jukema14,16, Naveed Sattar13, Emanuele Di Angelantonio1,17, Danish Saleheen18,19, Joanna M. M. Howson1, Børge G. Nordestgaard11,6,7,8, Adam S. Butterworth1,17, John Danesh1,17,20
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
2Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom
3Institute for Advanced Studies, University of Bristol, Bristol, United Kingdom
4School of Medicine, Wayne State University, Detroit, Michigan
5MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom
6Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark
7Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
8The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark
9Department of Neurology, Medizinische Universität Innsbruck, Innsbruck, Austria
10Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
11Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
12Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
13Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
14Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
15Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
16Netherlands Heart Institute, Utrecht, The Netherlands
17National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom
18Centre for Non-Communicable Diseases, Karachi, Pakistan
19Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
20Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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