Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study

Arthritis Research & Therapy - Tập 8 - Trang 1-3 - 2006
Christopher Butt1, Lynette Peddle1, Celia Greenwood2, Sean Hamilton1, Dafna Gladman3, Proton Rahman1
1Memorial University of Newfoundland, Hospital for Sick Children, Department of Public Health Sciences, University of Toronto, Toronto, Canada
2Genetics and Genomic Biology, Hospital for Sick Children, Department of Public Health Sciences, University of Toronto, Toronto, Canada
3University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Canada

Tóm tắt

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.

Tài liệu tham khảo

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Arthritis Research & Therapy

Tập 8

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