Association of anticoagulant-related bleeding events with cancer detection in atrial fibrillation: A systematic review and meta-analysis

Farmakis, 2013, Clinical profile and therapeutic management of patients with atrial fibrillation in greece: Results from the registry of atrial fibrillation to investigate new guidelines (RAFTING), Hellenic J Cardiol, 54, 368 Chugh, 2014, Worldwide epidemiology of atrial fibrillation: A global burden of disease 2010 study, Circulation, 129, 837, 10.1161/CIRCULATIONAHA.113.005119 Zoni-Berisso, 2014, Epidemiology of atrial fbrillation: European perspective, Clin Epidemiol, 6, 213, 10.2147/CLEP.S47385 Tsounis, 2014, Assessment of health-related quality of life in a greek symptomatic population with atrial fibrillation: Correlation with functional status and echocardiographic indices, Hellenic J Cardiol, 55, 475 Res, 2019, Health-related quality of life after adverse bleeding events associated with antithrombotic drug therapy – A systematic review, Hellenic J Cardiol, 60, 3, 10.1016/j.hjc.2018.06.012 Ostenfeld, 2014, Atrial fibrillation as a marker of occult cancer, PloS One, 9, 10.1371/journal.pone.0102861 Marijon, 2013, Causes of death and influencing factors in patients with atrial fibrillation: A competing-risk analysis from the randomized evaluation of long-term anticoagulant therapy study, Circulation, 128, 2192, 10.1161/CIRCULATIONAHA.112.000491 Connolly, 2009, Dabigatran versus warfarin in patients with atrial fibrillation, N Engl J Med, 361, 1139, 10.1056/NEJMoa0905561 Rahman, 2016, Association of atrial fibrillation and cancer, JAMA Cardiol, 1, 384, 10.1001/jamacardio.2016.0582 Rex, 2017, Colorectal Cancer Screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on colorectal cancer, Am J Gastroenterol, 112, 1016, 10.1038/ajg.2017.174 Yu, 2017, Clinical significance of hematuria in atrial fibrillation with oral anticoagulation therapy, Circ J, 81, 158, 10.1253/circj.CJ-16-0917 Kirchhof, 2016, 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS, Eur J Cardio Thorac Surg, 50, e1, 10.1093/ejcts/ezw313 Papakonstantinou, 2016, Anticoagulation management in non-valvular atrial fibrillation in rural and remote crete. A single-center study from the region of Sitia, Hellenic J Cardiol, 57, 279, 10.1016/j.hjc.2016.05.005 Archontakis, 2018, Novel therapeutic options in the prevention of atrial fibrillation, Hellenic J Cardiol, 59, 279, 10.1016/j.hjc.2018.12.001 Rasmussen, 2020, Gastrointestinal bleeding and the risk of colorectal cancer in anticoagulated patients with atrial fibrillation, Eur Heart J, 1 Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ, 339, b2700, 10.1136/bmj.b2700 Rakap, 2016, Computers in Human Behavior Comparative evaluation of the reliability and validity of three data extraction programs : UnGraph , GraphClick , and DigitizeIt, Comput Hum Behav, 55, 159, 10.1016/j.chb.2015.09.008 Sterne, 2016, ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions, BMJ, 355, i4919, 10.1136/bmj.i4919 Hu, 2019, Bleeding and new-onset cancers in patients with atrial fibrillation receiving nonvitamin K antagonist oral anticoagulants, Am J Cardiol, 123, 782, 10.1016/j.amjcard.2018.11.046 Koike, 2018, Bleeding with oral anticoagulant dabigatran is highly associated with occult cancers in atrial fibrillation patients, Future Cardiol, 14, 27, 10.2217/fca-2017-0063 Clemens, 2014, Anticoagulant-related gastrointestinal bleeding — could this facilitate early detection of benign or malignant gastrointestinal lesions ?, Ann Med, 46, 672, 10.3109/07853890.2014.952327 Michaels, 1962, Bleeding from occult tumors during anticoagulant therapy, Circulation, 25, 804, 10.1161/01.CIR.25.5.804 Ambrus, 2016, The impact of new-onset cancer among veterans who are receiving warfarin for atrial fibrillation and venous thromboembolism, Thromb Res, 144, 21, 10.1016/j.thromres.2016.05.028 Ruff, 2014, Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation : a meta-analysis of randomised trials, Lancet, 383, 955, 10.1016/S0140-6736(13)62343-0 Desai, 2013, Gastrointestinal bleeding with the new oral anticoagulants - Defining the issues and the management strategies, Thromb Haemostasis, 110, 205, 10.1160/TH13-02-0150 Chang, 2020, Risks and outcomes of gastrointestinal malignancies in anticoagulated atrial fibrillation patients experiencing gastrointestinal bleeding: A nationwide cohort study, Heart Rhythm, 17, 1745, 10.1016/j.hrthm.2020.05.026 Lagi, 2011, Upper digestive bleeding in atrial fibrillation: evaluation of gastroscopy prior to oral anticoagulant therapy (GOAT), prospective, randomized, double blind study on a community population, Cardiol Res, 2, 66-71 Flack, 2017, Major gastrointestinal bleeding often is caused by occult malignancy in patients receiving warfarin or dabigatran to prevent stroke and systemic embolism from atrial fibrillation, Clin Gastroenterol Hepatol, 15, 682, 10.1016/j.cgh.2016.10.011 Vaduganathan, 2017, Gastrointestinal bleeding with oral anticoagulation: Understanding the scope of the problem, Clin Gastroenterol Hepatol, 15, 691, 10.1016/j.cgh.2016.12.033 Rasmussen, 2020 Samaras, 2020, Rationale and design of a randomized study comparing Motivational Interviewing to Support Oral Anticoagulation adherence versus usual care in patients with nonvalvular atrial fibrillation: The MISOAC-AF trial, Hellenic J Cardiol, 61, 453, 10.1016/j.hjc.2020.02.007