Association of KCNJ11 and ABCC8 single-nucleotide polymorphisms with type 2 diabetes mellitus in a Kinh Vietnamese population

Medicine (United States) - Tập 101 Số 46 - Trang e31653 - 2022
Nam Quang Tran1,2, Steven Truong3, Phat Tung1,2, Chi Khanh Hoang2, Bao Hoang Le2, Thang Tat Ngo Dinh2, Luong Tran2, Thang Viet Tran1,2, Linh Hoang Gia Le4, Khuong Thai Le4, Hien Thanh Nguyen5, Hoàng Anh Vũ6,4,7, Thao Phuong8, Duc M4
1Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
2Department of Endocrinology, University Medical Center, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
3Department of Medicine, School of Medicine, Stanford University, USA
4Center for Molecular Biomedicine, University of Medicine and Pharmacy, at Ho Chi Minh City, Vietnam
5Department of Medical Laboratory Technology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
6101:46(e31653).
7How to cite this article: Tran NQ, Truong SD, Ma PT, Hoang CK, Le BH, Dinh TTN, Tran LV, Tran TV, Le LHG, Le KT, Nguyen HT, Vu HA, Mai TP, Do MD. Association of KCNJ11 and ABCC8 single-nucleotide polymorphisms with type 2 diabetes mellitus in a Kinh Vietnamese population. Medicine 2022
8Department of Physiology-Pathophysiology-Immunology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.

Tóm tắt

Type 2 diabetes mellitus (T2DM) is a genetically influenced disease, but few studies have been performed to investigate the genetic basis of T2DM in Vietnamese subjects. Thus, the potential associations of KCNJ11 and ABCC8 single nucleotide polymorphisms (SNPs) with T2DM were investigated in a Kinh Vietnamese population. A cross-sectional study consisting of 404 subjects including 202 T2DM cases and 202 non-T2DM controls was designed to examine the potential associations of 4 KCNJ11 and ABCC8 SNPs (rs5219, rs2285676, rs1799859, and rs757110) with T2DM. Genotypes were identified based on restriction fragment length polymorphism and tetra-primer amplification refractory mutation system polymerase chain reaction. After statistically adjusting for age, sex, and BMI, rs5219 was found to be associated with an increased risk of T2DM under 2 inheritance models: codominant (OR = 2.15, 95% confidence intervals [CI] = 1.09–4.22) and recessive (OR = 2.08, 95%CI = 1.09–3.94). On the other hand, rs2285676, rs1799859, and rs757110 were not associated with an increased risk of T2DM. Haplotype analysis elucidated a strong linkage disequilibrium between the 3 SNPs, rs5219, rs2285676, and rs757110. The haplotype rs5219(A)/rs2285676(T)/rs757110(G) was associated with an increased risk of T2DM (OR = 1.42, 95%CI = 1.01–1.99). The results show that rs5219 is a lead candidate SNP associated with an increased risk of developing T2DM in the Kinh Vietnamese population. Further functional characterization is needed to uncover the mechanism underlying the potential genotype-phenotype associations.

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Medicine (United States)

Tập 101 Số 46

e31653

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