Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

PLoS Medicine - Tập 11 Số 11 - Trang e1001755
Nils C. Gassen1, Jakob Hartmann2, Jürgen Zschocke1, Jens Stepan2, Kathrin Hafner1, Andreas Zellner1, Thomas Kirmeier3, Lorenz Korbinian Kollmannsberger1, Klaus V. Wagner2, Nina Dedic2, Georgia Balsevich2, Jan M. Deussing2, Stefan Kloiber3, Susanne Lucae3, Herta Flor3, Matthias Eder2, Manfred Uhr1, Marcus Ising3, Mathias V. Schmidt2, Theo Rein1
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
2Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany
3Department of Clinical Research, Max Planck Institute of Psychiatry, Munich, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

RC Kessler, 2009, The WHO World Mental Health (WMH) Surveys, Psychiatrie (Stuttg), 6, 5

JR Geddes, 2013, Treatment of bipolar disorder, Lancet, 381, 1672, 10.1016/S0140-6736(13)60857-0

T Klengel, 2013, Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions, Nat Neurosci, 16, 33, 10.1038/nn.3275

BK Attwood, 2011, Neuropsin cleaves EphB2 in the amygdala to control anxiety, Nature, 473, 372, 10.1038/nature09938

J Hartmann, 2012, The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress, Neuropharmacology, 62, 332, 10.1016/j.neuropharm.2011.07.041

C Touma, 2011, FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior, Biol Psychiatry, 70, 928, 10.1016/j.biopsych.2011.07.023

GM Wochnik, 2005, FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells, J Biol Chem, 280, 4609, 10.1074/jbc.M407498200

EB Binder, 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment, Nat Genet, 36, 1319, 10.1038/ng1479

M Lekman, 2008, The FKBP5-gene in depression and treatment response—an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort, Biol Psychiatry, 63, 1103, 10.1016/j.biopsych.2007.10.026

YF Zou, 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders, Neurosci Lett, 484, 56, 10.1016/j.neulet.2010.08.019

G Laje, 2009, Pharmacogenetics studies in STAR*D: strengths, limitations, and results, Psychiatr Serv, 60, 1446, 10.1176/ps.2009.60.11.1446

ER De Kloet, 2005, Stress and the brain: from adaptation to disease, Nat Rev Neurosci, 6, 463, 10.1038/nrn1683

F Holsboer, 2000, The corticosteroid receptor hypothesis of depression, Neuropsychopharmacology, 23, 477, 10.1016/S0893-133X(00)00159-7

J Zschocke, 2011, Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons—dissociation from cholesterol homeostasis, Neuropsychopharmacology, 36, 1754, 10.1038/npp.2011.57

M Rossi, 2009, Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux, J Cell Sci, 122, 3330, 10.1242/jcs.048181

M Taipale, 2010, HSP90 at the hub of protein homeostasis: emerging mechanistic insights, Nat Rev Mol Cell Biol, 11, 515, 10.1038/nrm2918

N Mizushima, 2011, Autophagy: renovation of cells and tissues, Cell, 147, 728, 10.1016/j.cell.2011.10.026

H Nakatogawa, 2009, Dynamics and diversity in autophagy mechanisms: lessons from yeast, Nat Rev Mol Cell Biol, 10, 458, 10.1038/nrm2708

RC Wang, 2012, Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation, Science, 338, 956, 10.1126/science.1225967

H Harris, 2012, Control of autophagy as a therapy for neurodegenerative disease, Nat Rev Neurol, 8, 108, 10.1038/nrneurol.2011.200

B Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

L Welberg, 2012, Neurotransmission: autophagy regulates transmission, Nat Rev Neurosci, 13, 362, 10.1038/nrn3266

Q Cai, 2010, Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons, Neuron, 68, 73, 10.1016/j.neuron.2010.09.022

J Ma, 2013, Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer, Anticancer Agents Med Chem, 13, 254, 10.2174/1871520611313020011

J Chen, 2012, Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy, PLoS ONE, 7, e34024, 10.1371/journal.pone.0034024

NZ Kara, 2013, Trehalose induced antidepressant-like effects and autophagy enhancement in mice, Psychopharmacology (Berl), 229, 367, 10.1007/s00213-013-3119-4

C Cleary, 2008, Antidepressive-like effects of rapamycin in animal models: implications for mTOR inhibition as a new target for treatment of affective disorders, Brain Res Bull, 76, 469, 10.1016/j.brainresbull.2008.03.005

EJ Nestler, 2010, Animal models of neuropsychiatric disorders, Nat Neurosci, 13, 1161, 10.1038/nn.2647

JM Deussing, 2006, Animal models of depression, Drug Discov Today, 3, 375

XD Wang, 2011, Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling, Neurobiol Dis, 42, 300, 10.1016/j.nbd.2011.01.020

O Berton, 2006, Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress, Science, 311, 864, 10.1126/science.1120972

JE Skeen, 2006, Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner, Cancer Cell, 10, 269, 10.1016/j.ccr.2006.08.022

T Perisic, 2010, Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes, Neuropsychopharmacology, 35, 792, 10.1038/npp.2009.188

B Franke, 1998, CNS glia are targets for GDNF and neurturin, Histochem Cell Biol, 110, 595, 10.1007/s004180050322

BG Schumann, 2011, Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters, Mol Biochem Parasitol, 175, 91, 10.1016/j.molbiopara.2010.09.002

D Kim, 2010, A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation, J Biol Chem, 285, 8383, 10.1074/jbc.M109.094060

A Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4

Y Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J, 19, 5720, 10.1093/emboj/19.21.5720

KV Wagner, 2012, Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment, Neuropsychopharmacology, 37, 2797, 10.1038/npp.2012.150

KV Wagner, 2011, Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress, Psychoneuroendocrinology, 36, 579, 10.1016/j.psyneuen.2010.09.007

KL McIlwain, 2001, The use of behavioral test batteries: effects of training history, Physiol Behav, 73, 705, 10.1016/S0031-9384(01)00528-5

SA Golden, 2011, A standardized protocol for repeated social defeat stress in mice, Nat Protoc, 6, 1183, 10.1038/nprot.2011.361

M Fluttert, 2000, A refined method for sequential blood sampling by tail incision in rats, Lab Anim, 34, 372, 10.1258/002367700780387714

M Uhr, 2000, Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption, Neuropsychopharmacology, 22, 380, 10.1016/S0893-133X(99)00095-0

M Uhr, 2003, Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption, Biol Psychiatry, 54, 840, 10.1016/S0006-3223(03)00074-X

JM Hennings, 2009, Clinical characteristics and treatment outcome in a representative sample of depressed inpatients—findings from the Munich Antidepressant Response Signature (MARS) project, J Psychiatr Res, 43, 215, 10.1016/j.jpsychires.2008.05.002

American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edition. Washington (District of Columbia): American Psychiatric Association.

JE Overall, 1982, Use of the Hamilton Rating Scale for classification of depressive disorders, Compr Psychiatry, 23, 370, 10.1016/0010-440X(82)90087-6

C Hiemke, 2011, AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011, Pharmacopsychiatry, 44, 195, 10.1055/s-0031-1286287

BG Taksande, 2009, Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine, Neuropharmacology, 57, 415, 10.1016/j.neuropharm.2009.06.035

CK Thoeringer, 2010, Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice, J Psychopharmacol, 24, 733, 10.1177/0269881109103091

N Galeotti, 2012, Selective modulation of the PKCvarepsilon/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline, Neuropharmacology, 62, 289, 10.1016/j.neuropharm.2011.07.020

H Pei, 2009, FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt, Cancer Cell, 16, 259, 10.1016/j.ccr.2009.07.016

DJ Klionsky, 2012, Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, 445, 10.4161/auto.19496

SH Jeon, 2011, The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells, Biochem Biophys Res Commun, 413, 311, 10.1016/j.bbrc.2011.08.093

W Huang, 2013, Fluoxetine upregulates phosphorylated-AKT and phosphorylated-ERK1/2 proteins in neural stem cells: evidence for a crosstalk between AKT and ERK1/2 pathways, J Mol Neurosci, 49, 244, 10.1007/s12031-012-9822-5

N Li, 2010, mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists, Science, 329, 959, 10.1126/science.1190287

B Voleti, 2013, Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses, Biol Psychiatry, 74, 742, 10.1016/j.biopsych.2013.04.025

TR Hubler, 2004, Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids, Cell Stress Chaperones, 9, 243, 10.1379/CSC-32R.1

E Laane, 2009, Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy, Cell Death Differ, 16, 1018, 10.1038/cdd.2009.46

JG Scammell, 2001, Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates, Gen Comp Endocrinol, 124, 152, 10.1006/gcen.2001.7696

MS Bhuiyan, 2011, Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding, Eur J Pharmacol, 650, 621, 10.1016/j.ejphar.2010.10.055

A Basta-Kaim, 2005, Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway, Neuropharmacology, 49, 156, 10.1016/j.neuropharm.2005.02.008

BD Manning, 2007, AKT/PKB signaling: navigating downstream, Cell, 129, 1261, 10.1016/j.cell.2007.06.009

O Berton, 2006, New approaches to antidepressant drug discovery: beyond monoamines, Nat Rev Neurosci, 7, 137, 10.1038/nrn1846

D Hernandez, 2012, Regulation of presynaptic neurotransmission by macroautophagy, Neuron, 74, 277, 10.1016/j.neuron.2012.02.020

CS Kim, 2012, Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors, Neuron, 75, 503, 10.1016/j.neuron.2012.05.027

JC O'Leary 3rd, 2011, A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51, PLoS ONE, 6, e24840, 10.1371/journal.pone.0024840

UK Jinwal, 2010, The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules, J Neurosci, 30, 591, 10.1523/JNEUROSCI.4815-09.2010

AL Barabasi, 2011, Network medicine: a network-based approach to human disease, Nat Rev Genet, 12, 56, 10.1038/nrg2918

L Luo, 2008, Genetic dissection of neural circuits, Neuron, 57, 634, 10.1016/j.neuron.2008.01.002