Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients

Chronic Diseases and Translational Medicine - Tập 2 - Trang 110-119 - 2016
Yi-Nan Li1,2, Bryan Shapiro1, Jun Chul Kim1,3, Min Zhang1,4, Janos Porszasz5, Rachelle Bross6,7, Usama Feroze8, Rajeev Upreti9, David Martin10, Kamyar Kalantar-Zadeh7,11,12, Joel David Kopple1,12,13
1Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor – UCLA Medical Center, Torrance, CA 90502, USA
2Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China
3Division of Nephrology, CHA Gumi Medical Center, CHA University, Kyungsangbuk-do 730728, South Korea
4Division of Nephrology, Tianjin Union Medical Center, Tianjin 300121, China
5Rehabilitation Clinical Trials Center, Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor – UCLA Medical Center, Torrance, CA 90502, USA
6UCLA Clinical and Translational Science Institute, Los Angeles Biomedical Research Institute at Harbor – UCLA Medical Center, Torrance, CA 90502, USA
7Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor – UCLA Medical Center, Torrance, CA 90502, USA
8George Washington University/Inova Fairfax Hospital Psychosomatic Fellowship Program, Washington, DC 20052, USA
9Max Super Specialty Hospital, New Delhi, Delhi 110092, India
10Division of Psychology, Department of Psychiatry, Harbor – UCLA Medical Center, Torrance, CA 90502, USA
11Division of Nephrology and Hypertension, University of California at Irvine, Irvine, CA 92697, USA
12UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA
13David Geffen School of Medicine at UCLA, Los Angeles, CA 90502, USA

Tóm tắt

AbstractObjectiveMaintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance.MethodsSeventy‐two relatively healthy adult MHD patients, vintage ≥6 months, and 39 normals of similar age range and gender distribution were studied. QOL was assessed using the Kidney Disease Quality of Life‐Short Form (KDQOL‐SF). Anxiety and depression were each evaluated with two questionnaires. DPA and physical performance were assessed with a physical activity monitor, Human Activity Profile, and 6‐minute walk, sit‐to‐stand, and stair‐climbing tests.ResultsMost KDQOL components were reduced in MHD patients versus normals. KDQOL components in patients were commonly inversely correlated with measures of anxiety and depression (P < 0.05) and were more reduced in patients with both anxiety and depression. KDQOL was often impaired in patients with either anxiety or depression. However, most KDQOL scores did not differ between patients and normals without anxiety or depression. DPA, Human Activity Profile, and physical performance often correlated with KDQOL scores in adjusted models, but after further adjustment for anxiety and depression, DPA, Human Activity Profile, and physical performance correlated less frequently with KDQOL scores. This reduction in significant correlations after adjustment for anxiety and depression was particularly pronounced for the association between KDQOL and DPA.ConclusionIn relatively healthy MHD patients, KDQOL scores are usually decreased in those with anxiety and/or depression but are usually normal in those without anxiety or depression. Lower DPA in MHD patients with reduced KDQOL scores often appears to be associated with anxiety and depression. The relationship between QOL and physical performance appears to be less influenced by anxiety and/or depression. These data suggest that treatment of anxiety and depression in MHD patients may improve their QOL, DPA, and possibly physical performance.

Tài liệu tham khảo

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Chronic Diseases and Translational Medicine

Tập 2

110-119

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