Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease

Baumgart DC, Carding SR (2007) Inflammatory bowel disease: cause and immunobiology. Lancet 369(9573):40–1627 Kappelman MD et al (2007) The prevalence and geographic distribution of Crohn’s disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol 5(12):9–1424 Lakatos PL (2006) Recent trends in the epidemiology of inflammatory bowel diseases: up or down? World J Gastroenterol 12(38):8–6102 Wang YF, Ouyang Q, Hu RW (2010) Progression of inflammatory bowel disease in China. J Dig Dis 11(2):76–82 Abraham C, Cho JH (2009) Inflammatory bowel disease. N Engl J Med 361(21):78–2066 Turner DM et al (1997) An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24(1):1–8 Kuhn R et al (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75(2):74–263 Amre DK et al (2009) Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn’s disease. Aliment Pharmacol Ther 29(9):31–1025 Garza-Gonzalez E et al (2010) Genetic risk factors for inflammatory bowel disease in a North-eastern Mexican population. Int J Immunogenet 37(5):9–355 Tedde A et al (2008) Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner. Scand J Gastroenterol 43(6):8–712 Howell WM, Rose-Zerilli MJ (2007) Cytokine gene polymorphisms, cancer susceptibility, and prognosis. J Nutr 137(1 Suppl):194S–199S Crawley E et al (1999) Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 42(6):8–1101 Hoffmann SC et al (2001) Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation 72(8):50–1444 Reuss E et al (2002) Differential regulation of interleukin-10 production by genetic and environmental factors–a twin study. Genes Immun 3(7):13–407 Ahirwar DK et al (2011) Role of tumor necrosis factor-alpha (C-863A) polymorphism in pathogenesis of inflammatory bowel disease in Northern India. J Gastrointest Cancer 42(3):149–154 Andersen V et al (2010) The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study. BMC Med Genet 11:82 Balding J et al (2004) Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms. Mediators Inflamm 13(3):7–181 Cantor MJ, Nickerson P, Bernstein CN (2005) The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. Am J Gastroenterol 100(5):42–1134 Castro-Santos P et al (2006) TNFalpha and IL-10 gene polymorphisms in inflammatory bowel disease. Association of -1082 AA low producer IL-10 genotype with steroid dependency. Am J Gastroenterol 101(5):47–1039 Celik Y et al (2006) Cytokine gene polymorphisms in Turkish patients with inflammatory bowel disease. Scand J Gastroenterol 41(5):65–559 Fernandez L et al (2005) Interleukin-10 polymorphisms in Spanish patients with IBD. Inflamm Bowel Dis 11(8):43–739 Hong J et al (2008) IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn’s disease patients. Int J Colorectal Dis 23(3):7–335 Klausz G et al (2005) Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn’s disease. Scand J Gastroenterol 40(10):204–1197 Klein W et al (2000) The IL-10 gene is not involved in the predisposition to inflammatory bowel disease. Electrophoresis 21(17):82–3578 Koss K et al (2000) Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. Genes Immun 1(3):90–185 Sanchez R et al (2009) IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn’s disease location. World J Gastroenterol 15(30):82–3776 Tagore A et al (1999) Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens 54(4):90–386 Wang AH et al (2011) The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn’s disease susceptibility in a New Zealand population. Hum Immunol 72(5):5–431 Cochran W (1954) The combination of estimates from different experiments. Biometrics 10:101–129 Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):58–1539 Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315(7121):7–1533 Egger M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):34–629 Clark MF, Baudouin SV (2006) A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 32(11):12–1706 Srivastava K et al (2011) Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis. Mutat Res 728(1–2):67–79 Ioannidis JP et al (2008) Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 37(1):32–120 Glocker EO et al (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 361(21):45–2033 van der Linde K et al (2003) A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease. Scand J Gastroenterol 38(6):7–611 Parkes M, Satsangi J, Jewell D (1998) Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility. Clin Exp Immunol 113(1):28–32 Juyal G et al (2011) An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians. PLoS One 6(1):e16565 Festen EA et al (2010) Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. Am J Gastroenterol 105(2):395–402 Shi J et al (2011) Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese. Inflamm Bowel Dis 17(12):9–2472 Ghaith OA et al (2010) Lack of correlation between IL-10R1 S138G loss-of-function allele and IBD in the Lebanese population. Inflamm Bowel Dis 16(11):20–1819 Grundtner P et al (2009) The IL-10R1 S138G loss-of-function allele and ulcerative colitis. Genes Immun 10(1):84–92 Gasche C et al (2003) Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. J Immunol 170(11):82–5578 Aithal GP et al (2001) Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease. Dig Dis Sci 46(7):5–1520 Moran CJ et al (2012) IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis 19(1):115–123 Marcuzzi A et al (2012) Inflammation profile of four early onset Crohn patients. Gene 493(2):5–282 Gasche C et al (2011) IL-10RA truncation mutations and Semite populations. Inflamm Bowel Dis 17(6):1438 Bernstein CN et al (2006) A population-based case control study of potential risk factors for IBD. Am J Gastroenterol 101(5):993–1002 Hugot JP et al (1999) Etiology of the inflammatory bowel diseases. Int J Colorectal Dis 14(1):2–9 Barbara G et al (2000) Interleukin 10 gene transfer prevents experimental colitis in rats. Gut 46(3):344–349 van Deventer SJ, Elson CO, Fedorak RN (1997) Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn’s disease. Crohn’s Disease Study Group. Gastroenterology 113(2):383–389