Association among lung function, exhaled nitric oxide, and the CAN questionnaire to assess asthma control in children

Pediatric Pulmonology - Tập 45 Số 5 - Trang 434-439 - 2010
Olaia Sardón1,2, Javier Korta‐Murua1,2, J. Valverde-Molina3, J.J. Fernández‐Paredes3, Javier Mintegui1, Paula Corcuera1, José Ignacio Pijoán4, E.G. Pérez‐Yarza1,2
1Department of Pediatrics, Division of Respiratory Medicine, Donostia Children's Hospital, San Sebastián, Spain
2Department of Pediatrics, Medical School (U.D. San Sebastian), University of the Basque Country, San Sebastián, Spain
3Department of Pediatrics, Division of Respiratory Medicine, Los Arcos Hospital, Murcia, Spain
4Epidemiology Unit (CIBER-ESP), Donostia Children's Hospital, San Sebastián, Spain

Tóm tắt

AbstractBackgroundThe aim of this study was to investigate the association among a validated symptom‐based questionnaire for asthma control in children (CAN), forced expiratory volume in 1 sec (FEV1), and fractional exhaled nitric oxide (FENO).MethodsObservational cross‐sectional study was performed in a consecutive sample of asthmatic children aged between 7 and 14 years old from December 2007 to February 2008. FENO was measured with a portable electrochemical analyzer and forced spirometry was performed according to American Thoracic Society/European Respiratory Society. The CAN questionnaire was completed by the parents (aged <9 years old) or by the children (≥9 years old). The strength of the association among FEV1, FENO, and CAN questionnaire was studied using Spearman's rho, and the degree of agreement for asthma control among FEV1, FENO, and CAN questionnaire, with classification of these variables according to values of normality, was studied using Pearson's χ2 test and Cohen's kappa (KC).ResultsWe studied 268 children, mean age 9.7 ± 2.1 years. Significant correlations were found between FENO and CAN (r = 0.2), between FEV1 and CAN (r = −0.3), and between FENO and FEV1 (r = −0.12). On classifying the variables according to values of normality, no agreement was found to establish the degree of asthma control between FENO and CAN (KC = 0.18, χ2 Pearson = 9.63); between FEV1 and CAN (KC = 0.29, χ2 = 38.5); or between FENO and FEV1 (KC = 0.07, χ2 = 4.9).ConclusionsThe association among the three measurement instruments used to assess asthma control (FEV1, FENO, and CAN) was weak. These are instruments that quantify variables that influence asthma in different ways, in this sense, none can be used instead of another in asthma management although they are complementary. Pediatr Pulmonol. 2010; 45:434–439. © 2010 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1111/j.1398-9995.2007.01586.x

10.1081/JAS-200027838

10.1136/thorax.58.12.1048

10.1081/JAS-200027862

10.1136/thorax.58.3.242

10.1111/j.1398-9995.2006.01250.x

10.1002/ppul.20929

Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention Updated2007. Available at:http://www.ginasthma.com.

British Guideline on the Management of Asthma (SIGN Updated Mayo 2008).A national clinical guideline. British Thoracic Society. Scottish Intercollegiate Guidelines Network. Update2008. Available at:http://www.sign.ac.uk/guidelines/fulltext/101/index.html.

Haynes RB, 1979, Compliance in health care

10.1183/09031936.05.00034805

Zapletal A, 1972, Assessment of airway function in children, Bull Physiopathol Respir (Nancy), 8, 535

10.1183/09031936.05.00035205

10.1002/ppul.20747

10.1002/ppul.20491

10.1016/S1695-4033(07)70806-8

10.1016/j.jaci.2005.03.020

10.1157/13099536

10.1002/ppul.20056

10.1016/j.jaci.2003.08.014

National Institutes of Health.National Asthma Education and Prevention Program. Expert Panel Report 3 (NAEPP EPR‐3). Guidelines for the Diagnosis and Management of Asthma2007. Available at:http://www.nhlbi.nih.gov/guidelines/asthma/index. htm.

10.1067/mpd.2003.187

Cano‐Garcinuño A, 2008, Clinical correlates of airway inflammation in children with asthma, Allergy, 63, 622

10.1016/j.rmed.2005.03.039

10.1111/j.1398-9995.2005.00735.x

10.1002/ppul.20469

10.1080/02770900500371344

10.1111/j.1365-2222.2007.02788.x

10.1016/j.jaci.2003.09.008

10.1016/j.jaci.2006.12.662

10.1136/thx.2004.023374

10.1111/j.1399-3038.2006.00394.x

10.1164/rccm.200807-1010OC

10.1186/1465-9921-7-67

10.1002/ppul.20417

10.1016/j.rmed.2005.03.039

10.1002/ppul.20632

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Pediatric Pulmonology

Tập 45 Số 5

434-439

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